198474-05-4
198474-05-4
Chemical Structure
PF-06840003
Synonym(s): EOS200271
- CAS No.: 198474-05-4
- Formula:C12H9FN2O2
- Molecular Weight:232.21
IUPAC Name: 3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione
InChIKey: MXKLDYKORJEOPR-UHFFFAOYSA-N
SMILES: O=C(C(C1=CNC2=C1C=C(F)C=C2)C3)NC3=O
Biological Activity: PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PF-06840003 | 99.87% | PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively. | ||||||||||||||||||||
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PF-06840003 (Standard) | ≥98% | PF-06840003 (Standard) is the analytical standard of PF-06840003 (HY-101111). This product is intended for research and analytical applications. PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively. | ||||||||||||||||||||
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References
- [1]. Tumang J, et al. PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr4863.
- [2]. Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. J Med Chem. 2017 Dec 14;60(23):9617-9629. [Content Brief]
Keywords
