2. PROTAC
  3. Ligands for E3 Ligase
  4. CRBN ligand-891

CRBN ligand-891 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-891 can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-891

CRBN ligand-891 Chemical Structure

CAS No. : 2618349-23-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
25 mg In-stock
50 mg In-stock
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CRBN ligand-891 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

CRBN ligand-891 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-891 can be linked to a target protein ligand via a linker to form a PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRBN ligand-891 Related Antibodies
Molecular Weight

244.25

Formula

C13H12N2O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC(=O)C(C2=COC=3C=CC(N)=CC32)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (58.51 mM; ultrasonic and warming and adjust pH to 3 with 1 M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0942 mL 20.4708 mL 40.9417 mL
5 mM 0.8188 mL 4.0942 mL 8.1883 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0942 mL 20.4708 mL 40.9417 mL 102.3541 mL
5 mM 0.8188 mL 4.0942 mL 8.1883 mL 20.4708 mL
10 mM 0.4094 mL 2.0471 mL 4.0942 mL 10.2354 mL
15 mM 0.2729 mL 1.3647 mL 2.7294 mL 6.8236 mL
20 mM 0.2047 mL 1.0235 mL 2.0471 mL 5.1177 mL
25 mM 0.1638 mL 0.8188 mL 1.6377 mL 4.0942 mL
30 mM 0.1365 mL 0.6824 mL 1.3647 mL 3.4118 mL
40 mM 0.1024 mL 0.5118 mL 1.0235 mL 2.5589 mL
50 mM 0.0819 mL 0.4094 mL 0.8188 mL 2.0471 mL
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CRBN ligand-891 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-8912618349-23-6CRBN ligand891CRBN ligand 891Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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