CRBN ligand-891
Based on 1 Customer Validation
CRBN ligand-891 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-891 can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity: 95.17%
- CAS No.: 2618349-23-6
- Formula: C13H12N2O3
- Molecular Weight:244.25
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2618349-23-6
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Appearance Solid
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Molecular Weight 244.25
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Formula C13H12N2O3
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Color Light yellow to yellow
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SMILES
O=C1NC(=O)C(C2=COC=3C=CC(N)=CC32)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 14.29 mg/mL (58.51 mM; ultrasonic and warming and adjust pH to 3 with 1 M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (250 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0942 mL | 20.4708 mL | 40.9417 mL | 102.3541 mL |
| 5 mM | 0.8188 mL | 4.0942 mL | 8.1883 mL | 20.4708 mL | |
| 10 mM | 0.4094 mL | 2.0471 mL | 4.0942 mL | 10.2354 mL | |
| 15 mM | 0.2729 mL | 1.3647 mL | 2.7294 mL | 6.8236 mL | |
| 20 mM | 0.2047 mL | 1.0235 mL | 2.0471 mL | 5.1177 mL | |
| 25 mM | 0.1638 mL | 0.8188 mL | 1.6377 mL | 4.0942 mL | |
| 30 mM | 0.1365 mL | 0.6824 mL | 1.3647 mL | 3.4118 mL | |
| 40 mM | 0.1024 mL | 0.5118 mL | 1.0235 mL | 2.5589 mL | |
| 50 mM | 0.0819 mL | 0.4094 mL | 0.8188 mL | 2.0471 mL |
CRBN ligand-891 Related Classifications
HY-W539393 Related Classifications
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