Necrostatin-1 (inactive control)
Based on 1 Customer Validation
Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 64419-92-7
- Formula: C12H11N3OS
- Molecular Weight:245.30
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | EC50 |
>10 μM
Compound: 48
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Effective concentration required for inhibition of necroptosis in FADD deficient Jurkat T cells treated with TNF-alpha
Effective concentration required for inhibition of necroptosis in FADD deficient Jurkat T cells treated with TNF-alpha
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[PMID: 16153840] |
| Jurkat | EC50 |
>100 μM
Compound: 5
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Inhibition of cellular necroptosis in TNFalpha treated FADD deficient human Jurkat cells
Inhibition of cellular necroptosis in TNFalpha treated FADD deficient human Jurkat cells
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[PMID: 18408713] |
Chemical Information
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CAS No. 64419-92-7
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Appearance Solid
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Molecular Weight 245.30
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Formula C12H11N3OS
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Color Light yellow to yellow
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SMILES
O=C(N1)C(CC2=CNC3=CC=CC=C32)NC1=S
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Synonyms
Nec-1 (inactive control)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMF : 20 mg/mL (81.53 mM; Need ultrasonic and warming)
DMSO : 14 mg/mL (57.07 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / DMF | 1 mM | 4.0766 mL | 20.3832 mL | 40.7664 mL | 101.9160 mL |
| 5 mM | 0.8153 mL | 4.0766 mL | 8.1533 mL | 20.3832 mL | |
| 10 mM | 0.4077 mL | 2.0383 mL | 4.0766 mL | 10.1916 mL | |
| 15 mM | 0.2718 mL | 1.3589 mL | 2.7178 mL | 6.7944 mL | |
| 20 mM | 0.2038 mL | 1.0192 mL | 2.0383 mL | 5.0958 mL | |
| 25 mM | 0.1631 mL | 0.8153 mL | 1.6307 mL | 4.0766 mL | |
| 30 mM | 0.1359 mL | 0.6794 mL | 1.3589 mL | 3.3972 mL | |
| 40 mM | 0.1019 mL | 0.5096 mL | 1.0192 mL | 2.5479 mL | |
| 50 mM | 0.0815 mL | 0.4077 mL | 0.8153 mL | 2.0383 mL | |
| DMF | 60 mM | 0.0679 mL | 0.3397 mL | 0.6794 mL | 1.6986 mL |
| 80 mM | 0.0510 mL | 0.2548 mL | 0.5096 mL | 1.2740 mL |
Necrostatin-1 (inactive control) Related Classifications
HY-121954 Related Classifications
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