Necrostatin-1 (inactive control)
Based on 1 Customer Validation
Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.9%
- CAS 番号: 64419-92-7
- 分子式: C12H11N3OS
- 分子量:245.30
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-15760
Necrostatin-1RIPK1 Inhibitor -
HY-16658B
Z-VAD-FMKPan-Caspase Inhibitor -
HY-B0240
DisulfiramALDH1 Inhibitor -
HY-15760R
Necrostatin-1 (Standard)RIPK1 Inhibitor -
HY-149258
KWCN-41RIPK1 Kinase Inhibitor -
HY-114349
HS-1371RIP kinase Inhibitor -
HY-135826
Necroptosis-IN-1Necroptosis Inhibitor -
HY-117200
Necrostatin-7Necroptosis Inhibitor -
HY-124546
Necrostatin-5Necroptosis/RIP1 Inhibitor
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | EC50 |
>10 μM
Compound: 48
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Effective concentration required for inhibition of necroptosis in FADD deficient Jurkat T cells treated with TNF-alpha
Effective concentration required for inhibition of necroptosis in FADD deficient Jurkat T cells treated with TNF-alpha
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[PMID: 16153840] |
| Jurkat | EC50 |
>100 μM
Compound: 5
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Inhibition of cellular necroptosis in TNFalpha treated FADD deficient human Jurkat cells
Inhibition of cellular necroptosis in TNFalpha treated FADD deficient human Jurkat cells
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[PMID: 18408713] |
化学情報
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CAS 番号 64419-92-7
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性状 Solid
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分子量 245.30
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分子式 C12H11N3OS
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Color Light yellow to yellow
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SMILES
O=C(N1)C(CC2=CNC3=CC=CC=C32)NC1=S
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別名
Nec-1 (inactive control)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMF : 20 mg/mL (81.53 mM; Need ultrasonic and warming)
DMSO : 14 mg/mL (57.07 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / DMF | 1 mM | 4.0766 mL | 20.3832 mL | 40.7664 mL | 101.9160 mL |
| 5 mM | 0.8153 mL | 4.0766 mL | 8.1533 mL | 20.3832 mL | |
| 10 mM | 0.4077 mL | 2.0383 mL | 4.0766 mL | 10.1916 mL | |
| 15 mM | 0.2718 mL | 1.3589 mL | 2.7178 mL | 6.7944 mL | |
| 20 mM | 0.2038 mL | 1.0192 mL | 2.0383 mL | 5.0958 mL | |
| 25 mM | 0.1631 mL | 0.8153 mL | 1.6307 mL | 4.0766 mL | |
| 30 mM | 0.1359 mL | 0.6794 mL | 1.3589 mL | 3.3972 mL | |
| 40 mM | 0.1019 mL | 0.5096 mL | 1.0192 mL | 2.5479 mL | |
| 50 mM | 0.0815 mL | 0.4077 mL | 0.8153 mL | 2.0383 mL | |
| DMF | 60 mM | 0.0679 mL | 0.3397 mL | 0.6794 mL | 1.6986 mL |
| 80 mM | 0.0510 mL | 0.2548 mL | 0.5096 mL | 1.2740 mL |
Necrostatin-1 (inactive control) 関連分類
HY-121954 関連分類
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