CRBN ligand-890

Cat. No.: HY-W539438 Purity: 96.74%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

CRBN ligand-890 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-890 can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-890 Chemical Structure

CAS No. : 2623101-33-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Biological Activity
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Description

CRBN ligand-890 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-890 can be linked to a target protein ligand via a linker to form a PROTAC.

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

308.13

Formula

C₁₃H₁₀BrNO₃

CAS No.

2623101-33-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC(=O)C(C2=COC=3C=CC(Br)=CC32)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (162.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2454 mL	16.2269 mL	32.4538 mL
5 mM	0.6491 mL	3.2454 mL	6.4908 mL
10 mM	0.3245 mL	1.6227 mL	3.2454 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.74%

Select Batch:

Data Sheet (250 KB) SDS (393 KB)

COA (259 KB) HNMR (258 KB) LCMS (339 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2454 mL	16.2269 mL	32.4538 mL	81.1346 mL
	5 mM	0.6491 mL	3.2454 mL	6.4908 mL	16.2269 mL
	10 mM	0.3245 mL	1.6227 mL	3.2454 mL	8.1135 mL
	15 mM	0.2164 mL	1.0818 mL	2.1636 mL	5.4090 mL
	20 mM	0.1623 mL	0.8113 mL	1.6227 mL	4.0567 mL
	25 mM	0.1298 mL	0.6491 mL	1.2982 mL	3.2454 mL
	30 mM	0.1082 mL	0.5409 mL	1.0818 mL	2.7045 mL
	40 mM	0.0811 mL	0.4057 mL	0.8113 mL	2.0284 mL
	50 mM	0.0649 mL	0.3245 mL	0.6491 mL	1.6227 mL
	60 mM	0.0541 mL	0.2704 mL	0.5409 mL	1.3522 mL
	80 mM	0.0406 mL	0.2028 mL	0.4057 mL	1.0142 mL
	100 mM	0.0325 mL	0.1623 mL	0.3245 mL	0.8113 mL

CRBN ligand-890 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-8902623101-33-5CRBN ligand890CRBN ligand 890Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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CRBN ligand-890

CRBN ligand-890 Related Antibodies

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