CRBN ligand-890
Based on 1 Customer Validation
CRBN ligand-890 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-890 can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity: 96.74%
- CAS No.: 2623101-33-5
- Formula: C13H10BrNO3
- Molecular Weight:308.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2623101-33-5
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Appearance Solid
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Molecular Weight 308.13
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Formula C13H10BrNO3
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Color Light yellow to yellow
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SMILES
O=C1NC(=O)C(C2=COC=3C=CC(Br)=CC32)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (162.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (250 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.2454 mL | 16.2269 mL | 32.4538 mL | 81.1346 mL |
| 5 mM | 0.6491 mL | 3.2454 mL | 6.4908 mL | 16.2269 mL | |
| 10 mM | 0.3245 mL | 1.6227 mL | 3.2454 mL | 8.1135 mL | |
| 15 mM | 0.2164 mL | 1.0818 mL | 2.1636 mL | 5.4090 mL | |
| 20 mM | 0.1623 mL | 0.8113 mL | 1.6227 mL | 4.0567 mL | |
| 25 mM | 0.1298 mL | 0.6491 mL | 1.2982 mL | 3.2454 mL | |
| 30 mM | 0.1082 mL | 0.5409 mL | 1.0818 mL | 2.7045 mL | |
| 40 mM | 0.0811 mL | 0.4057 mL | 0.8113 mL | 2.0284 mL | |
| 50 mM | 0.0649 mL | 0.3245 mL | 0.6491 mL | 1.6227 mL | |
| 60 mM | 0.0541 mL | 0.2704 mL | 0.5409 mL | 1.3522 mL | |
| 80 mM | 0.0406 mL | 0.2028 mL | 0.4057 mL | 1.0142 mL | |
| 100 mM | 0.0325 mL | 0.1623 mL | 0.3245 mL | 0.8113 mL |
CRBN ligand-890 Related Classifications
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