1204669-58-8
Chemical Structure
Epacadostat
Synonym(s): INCB 024360
- CAS No.: 1204669-58-8
- Formula:C11H13BrFN7O4S
- Molecular Weight:438.23
IUPAC Name: (Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-((2-(sulfamoylamino)ethyl)amino)-1,2,5-oxadiazole-3-carboximidamide
InChIKey: FBKMWOJEPMPVTQ-UHFFFAOYSA-N
SMILES: BrC1=C(F)C=CC(N/C(C2=NON=C2NCCNS(N)(=O)=O)=N\O)=C1
Biological Activity: Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM[1]. Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Epacadostat | 99.72% | Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM. Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Epacadostat (Standard) | 98.35% | Epacadostat (Standard) is the analytical standard of Epacadostat. This product is intended for research and analytical applications. Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.85
HY-172233INCB-056868 -
Similarity Score 0.83
HY-16987IDO-IN-3 -
Similarity Score 0.76
HY-110387IDO-IN-9 -
Similarity Score 0.72
HY-144465IDO1-IN-15 -
Similarity Score 0.71
HY-149982IDO1-IN-22 -
Similarity Score 0.70
HY-146215IDO1-IN-20 -
Similarity Score 0.62
HY-111234IDO-IN-11 -
Similarity Score 0.60
HY-112147IDO1 and HDAC1 Inhibitor -
Similarity Score 0.57
HY-148572NAMPT/IDO1-IN-1 -
Explore the MedChemAI to find more analogs
