1204669-58-8
Chemical Structure
Epacadostat
Synonym(s): INCB 024360
- CAS No.: 1204669-58-8
- Formula:C11H13BrFN7O4S
- Molecular Weight:438.23
IUPAC Name: (Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-((2-(sulfamoylamino)ethyl)amino)-1,2,5-oxadiazole-3-carboximidamide
InChIKey: FBKMWOJEPMPVTQ-UHFFFAOYSA-N
SMILES: BrC1=C(F)C=CC(N/C(C2=NON=C2NCCNS(N)(=O)=O)=N\O)=C1
Biological Activity: Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM[1]. Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Epacadostat | 99.72% | Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM. Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion. | ||||||||||||||||||||
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Epacadostat (Standard) | 98.35% | Epacadostat (Standard) is the analytical standard of Epacadostat. This product is intended for research and analytical applications. Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM. | ||||||||||||||||||||
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