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Cat. No.: HY-146215

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IDO1-IN-20

Hy-146215 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.

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CAS No.: 2415246-15-8
Formule: C₁₅H₁₉BrFN₇O₄S
Masse moléculaire:492.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

IDO1-IN-20 Chemical Structure

CAS No.: 2415246-15-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

Hy-146215 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.

Voir tous les produits spécifiques à Isoform Indoleamine 2,3-Dioxygenase (IDO) :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	EC₅₀	69 nM Compound: 81	Antiproliferative activity against human HEK293T cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human HEK293T cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33569941]

Chemical Information

CAS No. 2415246-15-8
Masse moléculaire 492.32
Formule C₁₅H₁₉BrFN₇O₄S
SMILES

NS(=O)(N1CCC[C@H](C1)CNC2=NON=C2/C(NC3=CC(Br)=C(C=C3)F)=N/O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Song X,et al. Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors. Eur J Med Chem. 2020 Mar 1;189:112059. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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IDO1-IN-20

Voir tous les produits spécifiques à Isoform Indoleamine 2,3-Dioxygenase (IDO)