IDO1-IN-22
IDO1-IN-22 (Compound 3) is a IDO1 inhibitor (biochemical hIDO1 IC50: 67.4 nM, HeLa hIDO1 IC50: 17.6 nM). IDO1-IN-22 has excellent antitumor efficacy in LLC xenograft model, as well as desirable pharmacokinetic (PK) profile.
For research use only. We do not sell to patients.
- CAS No.: 2126853-16-3
- Formula: C12H12BrFN6O3
- Molecular Weight:387.16
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CT26 | IC50 |
34.9 μM
Compound: 3
|
Cytotoxicity against mouse CT26 cells assessed as cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against mouse CT26 cells assessed as cell viability measured after 24 hrs by CCK-8 assay
|
[PMID: 36842272] |
| HCT-116 | IC50 |
19.6 μM
Compound: 3
|
Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 24 hrs by CCK-8 assay
|
[PMID: 36842272] |
| HeLa | IC50 |
46.1 μM
Compound: 3
|
Cytotoxicity against human HeLa cells assessed as cell viability measured after 24 hrs by CCK-8 assay
Cytotoxicity against human HeLa cells assessed as cell viability measured after 24 hrs by CCK-8 assay
|
[PMID: 36842272] |
Chemical Information
-
CAS No. 2126853-16-3
-
Molecular Weight 387.16
-
Formula C12H12BrFN6O3
-
SMILES
CCNC(NC1=NON=C1/C(NC2=CC=C(C(Br)=C2)F)=N/O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz