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Cat. No.: HY-112147

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IDO1 and HDAC1 Inhibitor

IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC₅₀s of 69.0 nM and 66.5 nM, respectively.

For research use only. We do not sell to patients.

CAS No.: 2227044-16-6
Formula: C₂₅H₂₂BrFN₈O₄
Molecular Weight:597.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

IDO1 and HDAC1 Inhibitor Chemical Structure

CAS No.: 2227044-16-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC₅₀s of 69.0 nM and 66.5 nM, respectively^[1].

IC₅₀ & Target^[1]

IDO1

69.0 nM (IC₅₀)

HDAC1

66.5 nM (IC₅₀)

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	0.17 μM Compound: 83	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33569941]
A549	IC₅₀	16.73 μM Compound: 10	Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay	[PMID: 29670692]
CT26	IC₅₀	59.84 μM Compound: 10	Antiproliferative activity against mouse CT26 cells after 48 hrs by CCK-8 assay Antiproliferative activity against mouse CT26 cells after 48 hrs by CCK-8 assay	[PMID: 29670692]
HCT-116	EC₅₀	5.1 μM Compound: 83	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33569941]
HCT-116	IC₅₀	5.12 μM Compound: 10	Antiproliferative activity against human HCT116 cells after 48 hrs by CCK-8 assay Antiproliferative activity against human HCT116 cells after 48 hrs by CCK-8 assay	[PMID: 29670692]
HT-29	IC₅₀	11.71 μM Compound: 10	Antiproliferative activity against human HT-29 cells after 48 hrs by CCK-8 assay Antiproliferative activity against human HT-29 cells after 48 hrs by CCK-8 assay	[PMID: 29670692]
Lewis lung carcinoma cell line	EC₅₀	18 μM Compound: 83	Antiproliferative activity against mouse Lewis lung carcinoma cell line cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against mouse Lewis lung carcinoma cell line cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33569941]
Lewis lung carcinoma cell line	IC₅₀	17.62 μM Compound: 10	Antiproliferative activity against mouse LLC cells after 48 hrs by CCK-8 assay Antiproliferative activity against mouse LLC cells after 48 hrs by CCK-8 assay	[PMID: 29670692]

Chemical Information

CAS No. 2227044-16-6
Molecular Weight 597.40
Formula C₂₅H₂₂BrFN₈O₄
SMILES

BrC1=CC(N/C(C2=NON=C2NCCNC(C3=CC=C(C(NC4=C(N)C=CC=C4)=O)C=C3)=O)=N/O)=CC=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fang K, et al. Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors. ACS Med Chem Lett. 2018 Mar 26;9(4):312-317. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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IDO1 and HDAC1 Inhibitor

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms

All HDAC Isoforms