country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-112147

Copy Link Print Information

IDO1 and HDAC1 Inhibitor

IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC₅₀s of 69.0 nM and 66.5 nM, respectively.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2227044-16-6
Formel: C₂₅H₂₂BrFN₈O₄
Molecular Weight:597.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

IDO1 and HDAC1 Inhibitor Chemical Structure

CAS. Nr.: 2227044-16-6

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC₅₀s of 69.0 nM and 66.5 nM, respectively^[1].

IC₅₀ & Target^[1]

IDO1

69.0 nM (IC₅₀)

HDAC1

66.5 nM (IC₅₀)

Alle Indoleamine 2,3-Dioxygenase (IDO) Isoform-spezifische Produkte anzeigen :

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	0.17 μM Compound: 83	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33569941]
A549	IC₅₀	16.73 μM Compound: 10	Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay	[PMID: 29670692]
CT26	IC₅₀	59.84 μM Compound: 10	Antiproliferative activity against mouse CT26 cells after 48 hrs by CCK-8 assay Antiproliferative activity against mouse CT26 cells after 48 hrs by CCK-8 assay	[PMID: 29670692]
HCT-116	EC₅₀	5.1 μM Compound: 83	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33569941]
HCT-116	IC₅₀	5.12 μM Compound: 10	Antiproliferative activity against human HCT116 cells after 48 hrs by CCK-8 assay Antiproliferative activity against human HCT116 cells after 48 hrs by CCK-8 assay	[PMID: 29670692]
HT-29	IC₅₀	11.71 μM Compound: 10	Antiproliferative activity against human HT-29 cells after 48 hrs by CCK-8 assay Antiproliferative activity against human HT-29 cells after 48 hrs by CCK-8 assay	[PMID: 29670692]
Lewis lung carcinoma cell line	EC₅₀	18 μM Compound: 83	Antiproliferative activity against mouse Lewis lung carcinoma cell line cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against mouse Lewis lung carcinoma cell line cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33569941]
Lewis lung carcinoma cell line	IC₅₀	17.62 μM Compound: 10	Antiproliferative activity against mouse LLC cells after 48 hrs by CCK-8 assay Antiproliferative activity against mouse LLC cells after 48 hrs by CCK-8 assay	[PMID: 29670692]

Chemical Information

CAS. Nr. 2227044-16-6
Molecular Weight 597.40
Formel C₂₅H₂₂BrFN₈O₄
SMILES

BrC1=CC(N/C(C2=NON=C2NCCNC(C3=CC=C(C(NC4=C(N)C=CC=C4)=O)C=C3)=O)=N/O)=CC=C1F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fang K, et al. Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors. ACS Med Chem Lett. 2018 Mar 26;9(4):312-317. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

IDO1 and HDAC1 Inhibitor

Alle Indoleamine 2,3-Dioxygenase (IDO) Isoform-spezifische Produkte anzeigen

Alle HDAC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

IDO1 and HDAC1 Inhibitor Related Classifications

HY-112147 Related Classifications