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Art. -Nr.: HY-184129

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IDO1/TDO-IN-15

IDO1/TDO-IN-15 is a dual IDO1/TDO inhibitor with an IDO1 IC₅₀ of 0.19 μM and a TDO IC₅₀ of 0.37 μM. IDO1/TDO-IN-15 is applicable to the research of cancer and Alzheimer's disease.

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CAS. Nr.: 2413970-98-4
Formel: C₂₀H₁₃FN₂O₄
Molecular Weight:364.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

IDO1/TDO-IN-15 Chemical Structure

CAS. Nr.: 2413970-98-4

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Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

IDO1

0.19 μM (IC₅₀)

Alle Indoleamine 2,3-Dioxygenase (IDO) Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.02 μM Compound: 9a	Inhibition of IDO1 in human HeLa cells Inhibition of IDO1 in human HeLa cells	[PMID: 32247733]

In Vitro

IDO1/TDO-IN-15 (compound 9a) potently inhibits purified IDO1 enzyme with an IC₅₀ of 0.19 μM, exhibiting activity comparable to INCB024360 (HY-15689)^[1].
IDO1/TDO-IN-15 inhibits purified TDO enzyme with an IC₅₀ of 0.37 μM^[1].
IDO1/TDO-IN-15 potently inhibits IDO1 in HeLa cells with an IC₅₀ of 0.02 μM, exhibiting activity equivalent to INCB024360 and better than its enzymatic IDO1 inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2413970-98-4
Molecular Weight 364.33
Formel C₂₀H₁₃FN₂O₄
SMILES

O=C(/C=C/C1=CC2=C(N=C3C(C4=CC(F)=CC=C4N3C2=O)=O)C=C1)OCC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Li Y, et al. Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase. Bioorg Med Chem Lett. 2020;30(11):127159. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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IDO1/TDO-IN-15

Alle Indoleamine 2,3-Dioxygenase (IDO) Isoform-spezifische Produkte anzeigen