IDO1/TDO-IN-15
IDO1/TDO-IN-15 is a dual IDO1/TDO inhibitor with an IDO1 IC50 of 0.19 μM and a TDO IC50 of 0.37 μM. IDO1/TDO-IN-15 is applicable to the research of cancer and Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 2413970-98-4
- Formula: C20H13FN2O4
- Molecular Weight:364.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IDO1 0.19 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.02 μM
Compound: 9a
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Inhibition of IDO1 in human HeLa cells
Inhibition of IDO1 in human HeLa cells
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[PMID: 32247733] |
In Vitro
IDO1/TDO-IN-15 (compound 9a) potently inhibits purified IDO1 enzyme with an IC50 of 0.19 μM, exhibiting activity comparable to INCB024360 (HY-15689)[1].
IDO1/TDO-IN-15 inhibits purified TDO enzyme with an IC50 of 0.37 μM[1].
IDO1/TDO-IN-15 potently inhibits IDO1 in HeLa cells with an IC50 of 0.02 μM, exhibiting activity equivalent to INCB024360 and better than its enzymatic IDO1 inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2413970-98-4
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Molecular Weight 364.33
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Formula C20H13FN2O4
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SMILES
O=C(/C=C/C1=CC2=C(N=C3C(C4=CC(F)=CC=C4N3C2=O)=O)C=C1)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IDO1/TDO-IN-15 Related Classifications
HY-184129 Related Classifications
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