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Cat. No.: HY-184129

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IDO1/TDO-IN-15

IDO1/TDO-IN-15 is a dual IDO1/TDO inhibitor with an IDO1 IC₅₀ of 0.19 μM and a TDO IC₅₀ of 0.37 μM. IDO1/TDO-IN-15 is applicable to the research of cancer and Alzheimer's disease.

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CAS No.: 2413970-98-4
Formule: C₂₀H₁₃FN₂O₄
Masse moléculaire:364.33

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IDO1/TDO-IN-15 Chemical Structure

CAS No.: 2413970-98-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

IDO1

0.19 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform Indoleamine 2,3-Dioxygenase (IDO) :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.02 μM Compound: 9a	Inhibition of IDO1 in human HeLa cells Inhibition of IDO1 in human HeLa cells	[PMID: 32247733]

In Vitro

IDO1/TDO-IN-15 (compound 9a) potently inhibits purified IDO1 enzyme with an IC₅₀ of 0.19 μM, exhibiting activity comparable to INCB024360 (HY-15689)^[1].
IDO1/TDO-IN-15 inhibits purified TDO enzyme with an IC₅₀ of 0.37 μM^[1].
IDO1/TDO-IN-15 potently inhibits IDO1 in HeLa cells with an IC₅₀ of 0.02 μM, exhibiting activity equivalent to INCB024360 and better than its enzymatic IDO1 inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

CAS No. 2413970-98-4
Masse moléculaire 364.33
Formule C₂₀H₁₃FN₂O₄
SMILES

O=C(/C=C/C1=CC2=C(N=C3C(C4=CC(F)=CC=C4N3C2=O)=O)C=C1)OCC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Li Y, et al. Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase. Bioorg Med Chem Lett. 2020;30(11):127159. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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