(E)-IDO1/TDO-IN-15
(E)-IDO1/TDO-IN-15 is an isomer of IDO1/TDO-IN-15 (HY-184129). IDO1/TDO-IN-15 is a dual IDO1/TDO inhibitor with an IDO1 IC50 of 0.19 μM and a TDO IC50 of 0.37 μM. (E)-IDO1/TDO-IN-15 is applicable to the research of cancer and Alzheimer's disease.
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- CAS. Nr.: 2414964-76-2
- Formel: C20H13FN2O4
- Molecular Weight:364.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
IDO1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.02 μM
Compound: 9a
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Inhibition of IDO1 in human HeLa cells
Inhibition of IDO1 in human HeLa cells
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[PMID: 32247733] |
In Vitro
(E)-IDO1/TDO-IN-15 (compound 9a) potently inhibits purified IDO1 enzyme with an IC50 of 0.19 μM, exhibiting activity comparable to INCB024360 (HY-15689)[1].
(E)-IDO1/TDO-IN-15 inhibits purified TDO enzyme with an IC50 of 0.37 μM[1].
(E)-IDO1/TDO-IN-15 potently inhibits IDO1 in HeLa cells with an IC50 of 0.02 μM, exhibiting activity equivalent to INCB024360 and better than its enzymatic IDO1 inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 2414964-76-2
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Molecular Weight 364.33
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Formel C20H13FN2O4
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SMILES
O=C1N2C(C(C3=CC(F)=CC=C32)=O)=NC4=CC=C(/C=C/C(OCC)=O)C=C41
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Reinheit & Dokumentation
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(E)-IDO1/TDO-IN-15 Related Classifications
HY-184129A Related Classifications
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