1680-44-0
1680-44-0
Chemical Structure
4-Phenyl-1H-1,2,3-triazole
- CAS No.: 1680-44-0
- Formula:C8H7N3
- Molecular Weight:145.16
IUPAC Name: 5-phenyl-1H-1,2,3-triazole
InChIKey: LUEYUHCBBXWTQT-UHFFFAOYSA-N
SMILES: C1(C2=CC=CC=C2)=CN=NN1
Biological Activity: 4-Phenyl-1H-1,2,3-triazole is a selective IDO1 inhibitor with an IC50 of 83 μM against human IDO1. 4-Phenyl-1H-1,2,3-triazole binds to the heme iron of IDO1 and occupies its active site, thereby inhibiting tryptophan catabolism. 4-Phenyl-1H-1,2,3-triazole can serve as a precursor for the synthesis of HIV-1 capsid protein inhibitors. 4-Phenyl-1H-1,2,3-triazole is applicable to research related to cancer and organic synthesis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Phenyl-1H-1,2,3-triazole | 99.35% | 4-Phenyl-1H-1,2,3-triazole is a selective IDO1 inhibitor with an IC50 of 83 μM against human IDO1. 4-Phenyl-1H-1,2,3-triazole binds to the heme iron of IDO1 and occupies its active site, thereby inhibiting tryptophan catabolism. 4-Phenyl-1H-1,2,3-triazole can serve as a precursor for the synthesis of HIV-1 capsid protein inhibitors. 4-Phenyl-1H-1,2,3-triazole is applicable to research related to cancer and organic synthesis. | ||||||||||||||||||||
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References
- [1]. Sun L, et al. Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities. Eur J Med Chem. 2020 Mar 15;190:112085.
- [2]. Röhrig UF, et al. Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition. Journal of medicinal chemistry. 2012 Jun 14;55(11):5270-90. [Content Brief]
