1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)
  3. Palmatine chloride

Palmatine chloride 

Cat. No.: HY-N0110 Purity: 96.21%
Handling Instructions

Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine chloride can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment.

For research use only. We do not sell to patients.

Palmatine chloride Chemical Structure

Palmatine chloride Chemical Structure

CAS No. : 10605-02-4

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10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
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1 g USD 99 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

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Description

Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine chloride can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1].

IC50 & Target[1]

IDO1

 

In Vitro

Palmatine exhibits more potent IDO-1 inhibitory activity , which IC50 on rhIDO-1 is 157 μM, and on HEK 293-hIDO-1 is 3 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Palmatine (oral administration; 50 or 100 mg/kg, 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS- induced Colitis BALB/c mice model[1]
Dosage: 50 or 100 mg/kg; 7 days
Administration: Oral administration
Result: Ameliorated DSS-induced colitis and prevented infiltration of inflammatory cells.
Molecular Weight

387.86

Formula

C21H22ClNO4

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (82.50 mM)

H2O : 5 mg/mL (12.89 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5782 mL 12.8912 mL 25.7825 mL
5 mM 0.5156 mL 2.5782 mL 5.1565 mL
10 mM 0.2578 mL 1.2891 mL 2.5782 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.45 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Palmatine chloride
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HY-N0110
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