1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)
  3. Palmatine

Palmatine 

Cat. No.: HY-N0110A
Handling Instructions

Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment.

For research use only. We do not sell to patients.

Palmatine Chemical Structure

Palmatine Chemical Structure

CAS No. : 3486-67-7

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Description

Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1].

IC50 & Target[1]

IDO1

 

In Vitro

Palmatine exhibits more potent IDO-1 inhibitory activity , which IC50 on rhIDO-1 is 157μM, and on HEK 293-hIDO-1 is 3 μM[1].

In Vivo

Palmatine (oral administration; 50 or 100 mg/kg, 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity[1].

Animal Model: DSS- induced Colitis BALB/c mice model[1]
Dosage: 50 or 100 mg/kg; 7 days
Administration: Oral administration
Result: Ameliorated DSS-induced colitis and prevented infiltration of inflammatory cells.
Molecular Weight

352.40

Formula

C₂₁H₂₂NO₄+

CAS No.

3486-67-7

SMILES

COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(OC)C=C4CC3)C=C2C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PalmatineIndoleamine 2,3-Dioxygenase (IDO)colitisInflammatory bowel diseaseIBDIDO-1ulcerativeCrohn’s diseaseUDCDInhibitorinhibitorinhibit

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Palmatine
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HY-N0110A
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