2488851-89-2
Chemical Structure
PROTAC IDO1 Degrader-1
- CAS No.: 2488851-89-2
- Formula:C40H53BrFN9O13
- Molecular Weight:966.80
IUPAC Name: (Z)-N-(3-bromo-4-fluorophenyl)-4-((26-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-6,9,12,15,18,21,24-heptaoxa-3-azahexacosyl)amino)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
InChIKey: BVQZWOPTIZSOAW-UHFFFAOYSA-N
SMILES: O=C1C2=C(NCCOCCOCCOCCOCCOCCOCCOCCNCCNC3=NON=C3/C(NC4=CC(Br)=C(C=C4)F)=N/O)C=CC=C2C(N1C5C(NC(CC5)=O)=O)=O
Biological Activity: PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1].
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PROTAC IDO1 Degrader-1 | 99.00% | PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells. | ||||||||||||||||||||
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Keywords
