2488851-89-2
Chemical Structure
PROTAC IDO1 Degrader-1
- CAS. Nr.: 2488851-89-2
- Formula:C40H53BrFN9O13
- Molecular Weight:966.80
IUPAC Name: (Z)-N-(3-bromo-4-fluorophenyl)-4-((26-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-6,9,12,15,18,21,24-heptaoxa-3-azahexacosyl)amino)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
InChIKey: BVQZWOPTIZSOAW-UHFFFAOYSA-N
SMILES: O=C1C2=C(NCCOCCOCCOCCOCCOCCOCCOCCNCCNC3=NON=C3/C(NC4=CC(Br)=C(C=C4)F)=N/O)C=CC=C2C(N1C5C(NC(CC5)=O)=O)=O
Biological Activity: PROTAC IDO1 Degrader-1 is a potent IDO1 (Indoleamine 2,3-dioxygenase 1) PROTAC degrader with a DC50 of 2.84 μM. PROTAC IDO1 Degrader-1 forms a ternary complex with IDO1 and the CRBN E3 ligase, and induces polyubiquitination of IDO1 followed by proteasomal degradation via the ubiquitin-proteasome system. PROTAC IDO1 Degrader-1 is applicable for related research on cancer immunity[1].
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PROTAC IDO1 Degrader-1 | 99.00% | PROTAC IDO1 Degrader-1 is a potent IDO1 (Indoleamine 2,3-dioxygenase 1) PROTAC degrader with a DC50 of 2.84 μM. PROTAC IDO1 Degrader-1 forms a ternary complex with IDO1 and the CRBN E3 ligase, and induces polyubiquitination of IDO1 followed by proteasomal degradation via the ubiquitin-proteasome system. PROTAC IDO1 Degrader-1 is applicable for related research on cancer immunity. | ||||||||||||||||||||
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