2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IDO-IN-7

IDO-IN-7  (Synonyms: NLG-919 analogue; GDC-0919 analogue)

Cat. No.: HY-13983 Purity: 99.98%
COA Handling Instructions

IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC50 of 38 nM.

For research use only. We do not sell to patients.

IDO-IN-7 Chemical Structure

IDO-IN-7 Chemical Structure

CAS No. : 1402836-58-1

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Solution
10 mM * 1 mL in DMSO USD 131 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 131 In-stock
Solid
10 mg USD 119 In-stock
50 mg USD 317 In-stock
100 mg USD 554 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC50 of 38 nM.

IC50 & Target

IDO1

38 nM (IC50)

In Vitro

IDO-IN-7 (NLG-919 analogue) is a potent IDO1 inhibitor (IC50=38 nM). The binding mode of IDO-IN-7 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme. IDO-IN-7 has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

282.38

Appearance

Solid

Formula

C18H22N2O
CAS No.
SMILES

OC(C1CCCCC1)CC(C2=C3C=CC=C2)N4C3=CN=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (177.07 mM; Need ultrasonic)

Ethanol : 25 mg/mL (88.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5413 mL 17.7066 mL 35.4133 mL
5 mM 0.7083 mL 3.5413 mL 7.0827 mL
10 mM 0.3541 mL 1.7707 mL 3.5413 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

  • 6.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.85 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.98%

COA (252 KB) LCMS (270 KB)

Handling Instructions (2659 KB)
References
Cell Assay

IDO-IN-7 (NLG-919 analogue) and the selected fragments 8, 15, and 18 are tested in cellular assay for their ability to cross cell membrane and inhibit IDO1 catalytic activity. The cell line of murine mastocytoma P1.HTR stably transfected with murine IDO1 (P1.IDO1) is cultured for 16 hrs in the presence of each compound at the concentration of 30 mM. The ability of P1.IDO1 cells to convert LTrp contained in the culture medium at the concentration of 78.4 μM into L-Kyn is then assessed after 16 hrs of incubation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

IDO-IN-71402836-58-1NLG-919 analogue GDC-0919 analogueIndoleamine 2,3-Dioxygenase (IDO)Inhibitorinhibitorinhibit

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