1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)
  3. (S)-Indoximod

(S)-Indoximod  (Synonyms: 1-Methyl-L-tryptophan; (S)-NLG-8189)

Cat. No.: HY-N0707 Purity: 99.47%
COA Handling Instructions

(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (Ki: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease.

For research use only. We do not sell to patients.

(S)-Indoximod Chemical Structure

(S)-Indoximod Chemical Structure

CAS No. : 21339-55-9

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (S)-Indoximod:

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (Ki: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease[1][2][3][4].

IC50 & Target

Indoleamine 2,3-Dioxygenase (IDO)[1]

In Vitro

(S)-Indoximod (750 μM, 24 h) reduces IDO activity in HEK293 cells transduced with human IDO1 gene[4].
(S)-Indoximod (0.5 mM, 48 h) makes the cells released from IFN-γ (100 ng/mL)-mediated G1 cell cycle arrest, and then promotes the apoptosis of hepatic stellate cells[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(S)-Indoximod (5 mg/day, i.p. for 3 weeks) reverses the Bacillus Calmette-Guerin (BCG)-induced neurotoxicity in mice[3].
(S)-Indoximod (200 mg/kg, oral gavage) shows delayed, lasts longer renoprotective effect than D isomer, and increases survival in the IRI rat model[4].
(S)-Indoximod (1-9 mg/kg, i.p.) reverses cognitive, anxiety, and depressive-like behavior in bile duct ligation (BDL) rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bile duct ligation (BDL) rats[5]
Dosage: 1-9 mg/kg
Administration: i.p., After the rats recovered for 7 days from BDL surgery.
Result: Increased the sucrose preference.
Prevents the increased number of buried marbles.
Improved learning and memory function.
Molecular Weight

218.25

Formula

C12H14N2O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 4.81 mg/mL (22.04 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5819 mL 22.9095 mL 45.8190 mL
5 mM 0.9164 mL 4.5819 mL 9.1638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 5 mg/mL (22.91 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.47%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5819 mL 22.9095 mL 45.8190 mL 114.5475 mL
5 mM 0.9164 mL 4.5819 mL 9.1638 mL 22.9095 mL
10 mM 0.4582 mL 2.2910 mL 4.5819 mL 11.4548 mL
15 mM 0.3055 mL 1.5273 mL 3.0546 mL 7.6365 mL
20 mM 0.2291 mL 1.1455 mL 2.2910 mL 5.7274 mL
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(S)-Indoximod Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
(S)-Indoximod
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HY-N0707
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