21339-55-9
21339-55-9
Chemical Structure
(S)-Indoximod
Synonym(s): 1-Methyl-L-tryptophan; (S)-NLG-8189
- CAS No.: 21339-55-9
- Formula:C12H14N2O2
- Molecular Weight:218.25
IUPAC Name: 1-methyl-L-tryptophan
InChIKey: ZADWXFSZEAPBJS-JTQLQIEISA-N
SMILES: N[C@@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O
Biological Activity: (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (Ki: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-Indoximod | 99.47% | (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (Ki: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease. | ||||||||||||||||||||
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(S)-Indoximod-d3 | 99.0% | (S)-Indoximod-d3 is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer. | ||||||||||||||||||||
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References
- [1]. Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719. [Content Brief]
- [2]. Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529. [Content Brief]
- [3]. Rana P, et al. Comparison of fluoxetine and 1-methyl-L-tryptophan in treatment of depression-like illness in Bacillus Calmette-Guerin-induced inflammatory model of depression in mice. J Basic Clin Physiol Pharmacol. 2016 Nov 1;27(6):569-576. [Content Brief]
- [4]. Čepcová D, et al. The protective effect of 1-methyltryptophan isomers in renal ischemia-reperfusion injury is not exclusively dependent on indolamine 2,3-dioxygenase inhibition. Biomed Pharmacother. 2021 Mar;135:111180. [Content Brief]
Keywords
