2. Metabolic Enzyme/Protease Apoptosis
  3. Indoleamine 2,3-Dioxygenase (IDO) Apoptosis
  4. (Rac)-Indoximod

(Rac)-Indoximod  (Synonyms: 1-Methyl-DL-tryptophan; (Rac)-NLG-8189)

Cat. No.: HY-133897 Purity: 98.13%
COA Handling Instructions

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(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes.

For research use only. We do not sell to patients.

(Rac)-Indoximod Chemical Structure

(Rac)-Indoximod Chemical Structure

CAS No. : 26988-72-7

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Based on 1 publication(s) in Google Scholar

Other Forms of (Rac)-Indoximod:

(Rac)-Indoximod Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (Rac)-Indoximod

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IDO1 IDO2 IDO

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes[1].

IC50 & Target[1]

IDO

 

In Vitro

(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Rac)-Indoximod Related Antibodies

Cell Viability Assay[1]

Cell Line: Human cardiac myofibroblasts (hCMs)
Concentration: 0.5 mM
Incubation Time: 3 days
Result: Growth retardation by IFN-γ was partially reversed on day 2, but cell viability was further reduced on day 3.
Molecular Weight

218.25

Formula

C12H14N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(CC1=CN(C)C2=C1C=CC=C2)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

0.1 M NaOH : 10 mg/mL (45.82 mM; Need ultrasonic)

DMSO : 4.76 mg/mL (21.81 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5819 mL 22.9095 mL 45.8190 mL
5 mM 0.9164 mL 4.5819 mL 9.1638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.13%

COA (254 KB) HNMR (195 KB) LCMS (112 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 0.1 M NaOH 1 mM 4.5819 mL 22.9095 mL 45.8190 mL 114.5475 mL
5 mM 0.9164 mL 4.5819 mL 9.1638 mL 22.9095 mL
10 mM 0.4582 mL 2.2910 mL 4.5819 mL 11.4548 mL
15 mM 0.3055 mL 1.5273 mL 3.0546 mL 7.6365 mL
20 mM 0.2291 mL 1.1455 mL 2.2910 mL 5.7274 mL
0.1 M NaOH 25 mM 0.1833 mL 0.9164 mL 1.8328 mL 4.5819 mL
30 mM 0.1527 mL 0.7637 mL 1.5273 mL 3.8183 mL
40 mM 0.1145 mL 0.5727 mL 1.1455 mL 2.8637 mL
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(Rac)-Indoximod Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Indoximod26988-72-71-Methyl-DL-tryptophan (Rac)-NLG-8189Indoleamine 2,3-Dioxygenase (IDO)ApoptosiscardiacmyofibroblastsapoptosisfibrosisInhibitorinhibitorinhibit

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