1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)
  3. (Rac)-Indoximod

(Rac)-Indoximod (Synonyms: 1-Methyl-DL-tryptophan; (Rac)-NLG-8189)

Cat. No.: HY-133897 Purity: 98.13%
Handling Instructions

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes.

For research use only. We do not sell to patients.

(Rac)-Indoximod Chemical Structure

(Rac)-Indoximod Chemical Structure

CAS No. : 26988-72-7

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Description

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes[1].

IC50 & Target[1]

IDO

 

In Vitro

(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion[1].

Cell Viability Assay[1]

Cell Line: Human cardiac myofibroblasts (hCMs)
Concentration: 0.5 mM
Incubation Time: 3 days
Result: Growth retardation by IFN-γ was partially reversed on day 2, but cell viability was further reduced on day 3.
Molecular Weight

218.25

Formula

C₁₂H₁₄N₂O₂

CAS No.

26988-72-7

SMILES

NC(CC1=CN(C)C2=C1C=CC=C2)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Keywords:

(Rac)-Indoximod1-Methyl-DL-tryptophan(Rac)-NLG-8189Indoleamine 2,3-Dioxygenase (IDO)cardiacmyofibroblastsapoptosisfibrosisInhibitorinhibitorinhibit

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(Rac)-Indoximod
Cat. No.:
HY-133897
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