26988-72-7
26988-72-7
Chemical Structure
(Rac)-Indoximod
Synonym(s): 1-Methyl-DL-tryptophan; (Rac)-NLG-8189
- CAS No.: 26988-72-7
- Formula:C12H14N2O2
- Molecular Weight:218.25
IUPAC Name: 1-methyltryptophan
InChIKey: ZADWXFSZEAPBJS-UHFFFAOYSA-N
SMILES: NC(CC1=CN(C)C2=C1C=CC=C2)C(O)=O
Biological Activity: (Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes[1].
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(Rac)-Indoximod | 99.60% | (Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes. | ||||||||||||||||||||
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