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Cat. No.: HY-154387

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1-Isopropyltryptophan

Name: 1-Isopropyltryptophan
Brand: MedChemExpress
SKU: HY-154387
Availability: PreOrder

(Synonyms: 1-IsoPT)

1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated ID0-1 and ID0-2 mRNA.

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CAS No.: 1219485-46-7
화학식: C₁₄H₁₈N₂O₂
분자량:246.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

1-Isopropyltryptophan Chemical Structure

CAS No.: 1219485-46-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated ID0-1 and ID0-2 mRNA^[1].

IC₅₀ & Target

^[1]

IDO1

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

In Vitro

1-Isopropyltryptophan (24 h) shows cytotoxicity for mouse DC 2.4 lines with an IC₅₀ value of 2.156 mM^[1].
1-Isopropyltryptophan (100 µM; 48 h) decreases the expression of IFN-γ (0.5 µg/ml) stimulated IDO-1 and IDO-2 mRNA in DC 2.4 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

RT-PCR^[1]

View Protocol

Cell Line:

DC 2.4 cells
Concentration:

100 µM
Incubation Time:

48 h
Result:

Decreased the ID0-1 and ID0-2 mRNA expression in IFN-γ (0.5 lg/ml) treated DCs.

Chemical Information

CAS No. 1219485-46-7
분자량 246.30
화학식 C₁₄H₁₈N₂O₂
SMILES

N[C@@H](CC1=CN(C(C)C)C2=C1C=CC=C2)C(O)=O
Synonyms

1-IsoPT
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Molecular Biology

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun T, et al. Novel 1-alkyl-tryptophan derivatives downregulate IDO1 and IDO2 mRNA expression induced by interferon-gamma in dendritic cells. Mol Cell Biochem. 2010 Sep;342(1-2):29-34. [Content Brief]

Calculators

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Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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