1-Isopropyltryptophan
1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated ID0-1 and ID0-2 mRNA.
For research use only. We do not sell to patients.
- CAS No.: 1219485-46-7
- Formula: C14H18N2O2
- Molecular Weight:246.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IDO1 |
In Vitro
1-Isopropyltryptophan (24 h) shows cytotoxicity for mouse DC 2.4 lines with an IC50 value of 2.156 mM[1].
1-Isopropyltryptophan (100 µM; 48 h) decreases the expression of IFN-γ (0.5 µg/ml) stimulated IDO-1 and IDO-2 mRNA in DC 2.4 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:DC 2.4 cells
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Concentration:100 µM
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Incubation Time:48 h
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Result:Decreased the ID0-1 and ID0-2 mRNA expression in IFN-γ (0.5 lg/ml) treated DCs.
Chemical Information
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CAS No. 1219485-46-7
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Molecular Weight 246.30
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Formula C14H18N2O2
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SMILES
N[C@@H](CC1=CN(C(C)C)C2=C1C=CC=C2)C(O)=O
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Synonyms
1-IsoPT
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1-Isopropyltryptophan Related Classifications
HY-154387 Related Classifications
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