2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. 1-Isopropyltryptophan

1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated ID0-1 and ID0-2 mRNA.

For research use only. We do not sell to patients.

1-Isopropyltryptophan Chemical Structure

1-Isopropyltryptophan Chemical Structure

CAS No. : 1219485-46-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

1-Isopropyltryptophan Related Antibodies

Top Publications Citing Use of Products

View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated ID0-1 and ID0-2 mRNA[1].

IC50 & Target[1]

IDO1

 

In Vitro

1-Isopropyltryptophan (24 h) shows cytotoxicity for mouse DC 2.4 lines with an IC50 value of 2.156 mM[1].
1-Isopropyltryptophan (100 µM; 48 h) decreases the expression of IFN-γ (0.5 µg/ml) stimulated IDO-1 and IDO-2 mRNA in DC 2.4 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Isopropyltryptophan Related Antibodies

RT-PCR[1]

Cell Line: DC 2.4 cells
Concentration: 100 µM
Incubation Time: 48 h
Result: Decreased the ID0-1 and ID0-2 mRNA expression in IFN-γ (0.5 lg/ml) treated DCs.
Molecular Weight

246.30

Formula

C14H18N2O2
CAS No.
SMILES

N[C@@H](CC1=CN(C(C)C)C2=C1C=CC=C2)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

1-Isopropyltryptophan Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Isopropyltryptophan1219485-46-71-IsoPTIndoleamine 2,3-Dioxygenase (IDO)DC 2.4 cellsID0-1ID0-2IFN-γInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
1-Isopropyltryptophan
Cat. No.:
HY-154387
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.