EIF4ENIF1 - eukaryotic translation initiation factor 4E nuclear import factor 1 Gene

Also Known as 4E-T; Clast4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56478

About EIF4ENIF1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,436,963-31,493,568 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 19.7), brain (RPKM 7.2) and 25 other tissues.

Summary

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

EIF4ENIF1 Products (3)

mRNA Protein Name
NM_001164501.2 NP_001157973.1 eukaryotic translation initiation factor 4E transporter isoform a
NM_001164502.2 NP_001157974.1 eukaryotic translation initiation factor 4E transporter isoform b
NM_019843.4 NP_062817.2 eukaryotic translation initiation factor 4E transporter isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinase binding IPI
IPI: Inferred from physical interaction
22966201 GOA
enables nuclear export signal receptor activity IDA
IDA: Inferred from direct assay
10856257 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10856257 GOA
Biological Process GO Annotation Evidence References Source
involved in P-body assembly IDA
IDA: Inferred from direct assay
22966201 GOA
involved in P-body assembly IMP
IMP: Inferred from mutant phenotype
16157702 GOA
involved in mRNA stabilization IDA
IDA: Inferred from direct assay
24335285 GOA
acts upstream of positive effect miRNA-mediated gene silencing by inhibition of translation IDA
IDA: Inferred from direct assay
24335285 GOA
involved in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
IDA: Inferred from direct assay
32354837 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
24335285 GOA
involved in negative regulation of translation IMP
IMP: Inferred from mutant phenotype
16157702 GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
IDA: Inferred from direct assay
32354837 GOA
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
28216671 GOA
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
16157702 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
28216671 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28216671 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4ENIF1 Protein Structure

EIF4E-T

EIF4E-T: Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E (30 - 713)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 985 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4E transporter

  • 2610509L04Rik

EIF4ENIF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF4ENIF1 Q9NRA8 EIF4E2 Homo sapiens O60573-1
Anti Tag CoIP
28698298
Intra
EIF4ENIF1 Q9NRA8 EIF4E Homo sapiens P06730-1
Anti Tag CoIP
28698298
Intra
EIF4ENIF1 Q9NRA8 DDX6 Homo sapiens P26196
BN-PAGE
26184334
Intra
EIF4ENIF1 Q9NRA8 HNRNPF Homo sapiens P52597
Validated Y2H
25416956
Intra
EIF4ENIF1 Q9NRA8 HNRNPF Homo sapiens P52597
Y2H Array
25416956
Intra
EIF4ENIF1 Q9NRA8 TXLNA Homo sapiens P40222
Validated Y2H
25416956
Intra
EIF4ENIF1 Q9NRA8 TXLNA Homo sapiens P40222
Y2H Array
25416956
Intra
EIF4ENIF1 Q9NRA8 TXLNA Homo sapiens P40222
Y2H Prey Pooling
25416956
Intra
EIF4ENIF1 Q9NRA8 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
EIF4ENIF1 Q9NRA8 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
EIF4ENIF1 Q9NRA8 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
EIF4ENIF1 Q9NRA8 OIP5 Homo sapiens O43482
Validated Y2H
25416956
Intra
EIF4ENIF1 Q9NRA8 OIP5 Homo sapiens O43482
Y2H Prey Pooling
25416956
Intra
EIF4ENIF1 Q9NRA8 EIF4E Homo sapiens P06730
Y2H Array
25416956
Intra
EIF4ENIF1 Q9NRA8 EIF4E Homo sapiens P06730
Pull Down
10856257
Intra
EIF4ENIF1 Q9NRA8 EIF4E Homo sapiens P06730
Y2H Pooling
19060904
Intra
EIF4ENIF1 Q9NRA8 EIF4E Homo sapiens P06730
Validated Y2H
25416956
Intra
EIF4ENIF1 Q9NRA8 EIF4E Homo sapiens P06730
Y2H Array
19060904
Intra
EIF4ENIF1 Q9NRA8 EIF4E Homo sapiens P06730
Affinity Chrom
10856257
Intra
EIF4ENIF1 Q9NRA8 DTX2 Homo sapiens Q86UW9
Validated Y2H
25416956
Intra
EIF4ENIF1 Q9NRA8 DTX2 Homo sapiens Q86UW9
Y2H Array
25416956
Intra
EIF4ENIF1 Q9NRA8 KRT19 Homo sapiens P08727
Y2H Prey Pooling
25416956
Intra
EIF4ENIF1 Q9NRA8 KRT19 Homo sapiens P08727
Validated Y2H
25416956
Intra
EIF4ENIF1 Q9NRA8 EFHC1 Homo sapiens Q5JVL4
Y2H Array
25416956
Intra
EIF4ENIF1 Q9NRA8 EFHC1 Homo sapiens Q5JVL4
Y2H Prey Pooling
25416956
Intra
EIF4ENIF1 Q9NRA8 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra
EIF4ENIF1 Q9NRA8 TTC19 Homo sapiens Q6DKK2
Validated Y2H
25416956
Intra
EIF4ENIF1 Q9NRA8 TTC19 Homo sapiens Q6DKK2
Y2H Array
25416956
Intra
EIF4ENIF1 Q9NRA8 TTC19 Homo sapiens Q6DKK2
Y2H Prey Pooling
25416956
Cross
EIF4ENIF1 Q9NRA8 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Y2H
18985028
Cross
EIF4ENIF1 Q9NRA8 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Y2H Prey Pooling
18985028
Cross
EIF4ENIF1 Q9NRA8 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Pull Down
18985028
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Suppurative Lymphadenitis

  • Suppurative Lymphadenopathy
Thymus Lymphoma

  • Thymic Lymphoma
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04280 EIF4ENIF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EIF4ENIF1 VGNC VGNC:72054
Mus musculus EIF4ENIF1 MGD MGI:1921453
Rattus norvegicus EIF4ENIF1 RGD RGD:1560908
Bos taurus EIF4ENIF1 VGNC VGNC:28414
Felis catus EIF4ENIF1 VGNC VGNC:61794
Canis familiaris EIF4ENIF1 VGNC VGNC:40288
Others EIF4ENIF1 NCBI