1. PI3K/Akt/mTOR
  2. mTOR

Cbz-B3A 

Cat. No.: HY-114267 Purity: >98.0%
Handling Instructions

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).

For research use only. We do not sell to patients.

Cbz-B3A Chemical Structure

Cbz-B3A Chemical Structure

CAS No. : 1884710-81-9

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5 mg USD 220 Get quote

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  • Biological Activity

  • Technical Information

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  • References

Description

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).

IC50 & Target

mTORC1 signaling[1].

In Vitro

Cbz-B3A slows cellular growth of some human leukemia cell lines, but is not cytotoxic.
Cbz-B3A has a larger effect on the phosphorylation of 4EBP1 than p70S6k compared to repamycin. Cbz-B3A inhibits mTOR through Ubiquilins.
Cbz-B3A decreases the incorporation of [35S]methionine/cysteine into protein in a dose-dependent manner, with maximal inhibition of 68% observed at 10 μM, and an EC50 of ~3 μM.

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4147 mL 7.0734 mL 14.1469 mL
5 mM 0.2829 mL 1.4147 mL 2.8294 mL
10 mM 0.1415 mL 0.7073 mL 1.4147 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

706.87

Formula

C₃₅H₅₈N₆O₉

CAS No.

1884710-81-9

SMILES

O=C(OC(C)(C)C)N/C(NC(OC(C)(C)C)=O)=N/CCC[[email protected]](NC(OC(C)(C)C)=O)C(NCCCCCCNC(OCC1=CC=CC=C1)=O)=O

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
Cbz-B3A
Cat. No.:
HY-114267
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Cbz-B3A

Cat. No.: HY-114267