2. PI3K/Akt/mTOR
  3. mTOR
  4. Cbz-B3A

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).

For research use only. We do not sell to patients.

Cbz-B3A Chemical Structure

Cbz-B3A Chemical Structure

CAS No. : 1884710-81-9

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Based on 1 publication(s) in Google Scholar

Cbz-B3A Related Antibodies

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Description

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).

IC50 & Target

mTORC1 signaling[1].
In Vitro

Cbz-B3A slows cellular growth of some human leukemia cell lines, but is not cytotoxic.
Cbz-B3A has a larger effect on the phosphorylation of 4EBP1 than p70S6k compared to repamycin. Cbz-B3A inhibits mTOR through Ubiquilins.
Cbz-B3A decreases the incorporation of [35S]methionine/cysteine into protein in a dose-dependent manner, with maximal inhibition of 68% observed at 10 μM, and an EC50 of ~3 μM.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cbz-B3A Related Antibodies
Molecular Weight

706.87

Formula

C35H58N6O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC(C)(C)C)N/C(NC(OC(C)(C)C)=O)=N/CCC[C@H](NC(OC(C)(C)C)=O)C(NCCCCCCNC(OCC1=CC=CC=C1)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (28.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4147 mL 7.0734 mL 14.1469 mL
5 mM 0.2829 mL 1.4147 mL 2.8294 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4147 mL 7.0734 mL 14.1469 mL 35.3672 mL
5 mM 0.2829 mL 1.4147 mL 2.8294 mL 7.0734 mL
10 mM 0.1415 mL 0.7073 mL 1.4147 mL 3.5367 mL
15 mM 0.0943 mL 0.4716 mL 0.9431 mL 2.3578 mL
20 mM 0.0707 mL 0.3537 mL 0.7073 mL 1.7684 mL
25 mM 0.0566 mL 0.2829 mL 0.5659 mL 1.4147 mL
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Cbz-B3A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cbz-B3A1884710-81-9mTORMammalian target of RapamycinInhibitorinhibitorinhibit

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