NUCC-0231068
NUCC-0231068 is a MNK1 and MNK2 inhibitor with IC50 values of 8 nM and 7 nM, respectively. NUCC-0231068 inhibits the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) at Ser209, with an IC50 of 23 nM in its purified form and 17 nM in its D2B form. NUCC-0231068 can be used in studies related to glioblastoma.
For research use only. We do not sell to patients.
- Formula: C16H15N7
- Molecular Weight:305.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MNK1 8 nM (IC50) |
MNK2 7 nM (IC50) |
eIF4E 23 nM (IC50) |
NUCC-0231068 potently inhibits purified MNK1 and MNK2 kinases with IC50 values of 8 nM and 7 nM, respectively[1].
NUCC-0231068 potently inhibits eIF4E Ser209 phosphorylation in LN229 glioblastoma cells with an IC50 of 23 nM in purified form and 17 nM in D2B form[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 305.34
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Formula C16H15N7
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SMILES
N#CC1=CN=C(N=C1N[C@@H]2CCNC2)N3C=NC4=C3C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NUCC-0231068 Related Classifications
HY-184004 Related Classifications
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