2. MAPK/ERK Pathway Cell Cycle/DNA Damage
  3. MNK Eukaryotic Initiation Factor (eIF)
  4. NUCC-0231068

NUCC-0231068 is a MNK1 and MNK2 inhibitor with IC50 values of 8 nM and 7 nM, respectively. NUCC-0231068 inhibits the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) at Ser209, with an IC50 of 23 nM in its purified form and 17 nM in its D2B form. NUCC-0231068 can be used in studies related to glioblastoma.

For research use only. We do not sell to patients.

NUCC-0231068

NUCC-0231068 Chemical Structure

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NUCC-0231068 Related Antibodies

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Description

NUCC-0231068 is a MNK1 and MNK2 inhibitor with IC50 values of 8 nM and 7 nM, respectively. NUCC-0231068 inhibits the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) at Ser209, with an IC50 of 23 nM in its purified form and 17 nM in its D2B form. NUCC-0231068 can be used in studies related to glioblastoma[1].

IC50 & Target[1]

MNK1

8 nM (IC50)

MNK2

7 nM (IC50)

eIF4E

23 nM (IC50)

In Vitro

NUCC-0231068 potently inhibits purified MNK1 and MNK2 kinases with IC50 values of 8 nM and 7 nM, respectively[1].
NUCC-0231068 potently inhibits eIF4E Ser209 phosphorylation in LN229 glioblastoma cells with an IC50 of 23 nM in purified form and 17 nM in D2B form[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NUCC-0231068 Related Antibodies
Molecular Weight

305.34

Formula

C16H15N7
SMILES

N#CC1=CN=C(N=C1N[C@@H]2CCNC2)N3C=NC4=C3C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NUCC-0231068 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NUCC-0231068NUCC0231068NUCC 0231068MNKEukaryotic Initiation Factor (eIF)Mitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseMNK1LN229 glioblastoma cellsglioblastoma cellskinomekinasenon-cancer celleukaryotic translation initiation factor 4EMNK2CDK7eIF4EInhibitorinhibitorinhibit

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