NUCC-0231068
NUCC-0231068 is a MNK1 and MNK2 inhibitor with IC50 values of 8 nM and 7 nM, respectively. NUCC-0231068 inhibits the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) at Ser209, with an IC50 of 23 nM in its purified form and 17 nM in its D2B form. NUCC-0231068 can be used in studies related to glioblastoma.
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- 화학식: C16H15N7
- 분자량:305.34
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
MNK1 8 nM (IC50) |
MNK2 7 nM (IC50) |
eIF4E 23 nM (IC50) |
In Vitro
NUCC-0231068 potently inhibits purified MNK1 and MNK2 kinases with IC50 values of 8 nM and 7 nM, respectively[1].
NUCC-0231068 potently inhibits eIF4E Ser209 phosphorylation in LN229 glioblastoma cells with an IC50 of 23 nM in purified form and 17 nM in D2B form[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 305.34
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화학식 C16H15N7
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SMILES
N#CC1=CN=C(N=C1N[C@@H]2CCNC2)N3C=NC4=C3C=CC=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NUCC-0231068 Related Classifications
HY-184004 Related Classifications
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