MNK Inhibitors

MNK1

MNK2

MNK

MNK Inhibitors & Degraders

Product Name	MNK1	MNK2	MNK	Purity
Tomivosertib	MNK1, IC₅₀: 1-2 nM	MNK2, IC₅₀: 1-2 nM		99.92%
CGP 57380	MNK1, IC₅₀: 2.2 μM			98.71%
Tinodasertib	MNK1, IC₅₀: 64 nM	MNK2, IC₅₀: 86 nM		99.60%
HD202A	MNK1, IC₅₀: 6.09 nM MNK1, Kd: 1.913 μM	MNK2, IC₅₀: 8.06 nM MNK2, Kd: 5.244 μM
MNK1/2-IN-10	MNK1, IC₅₀: 10.84 nM	MNK2, IC₅₀: 12.81 nM
SLV-2436	MNK1, IC₅₀: 10.8 nM	MNK2, IC₅₀: 5.4 nM		98.03%
PROTAC MNK1 degrader-1	MNK1, DC₅₀: 11.92 nM			98.93%
EB1	MNK1, IC₅₀: 0.69 μM	MNK2, IC₅₀: 9.4 μM		99.91%
MNK inhibitor 9	MNK1, IC₅₀: 0.003 μM	MNK2, IC₅₀: 0.003 μM		99.38%
Cercosporamide			Mnk	99.0%
DS12881479	MNK1, IC₅₀: 387 nM			99.63%
ETP-45835	MNK1, IC₅₀: 575 nM	MNK2, IC₅₀: 646 nM
ETC-168	MNK1, IC₅₀: 23 nM	MNK2, IC₅₀: 43 nM
Galeterone hydrochloride	MNK1	MNK2
HSN748	MNK1	MNK2
HSND80	MNK1, Kd: 44 nM	MNK2, Kd: 4 nM
MNK1/2-IN-6	MNK1, IC₅₀: 2.3 nM	MNK2, IC₅₀: 3.4 nM
MNK1/2-IN-11	MNK1, IC₅₀: 1.2 nM	MNK2, IC₅₀: 1.3 nM
K783-0308		MNK2, IC₅₀: 406 nM
VNPP433-3β hydrochloride	MNK1	MNK2
MNK1/2-IN-8	MNK1, IC₅₀: 0.8 nM	MNK2, IC₅₀: 1.5 nM
MNK1/2-IN-7	MNK1, IC₅₀: 4.4 nM ([1])	MNK2, IC₅₀: 0.4 nM ([1])
NUCC-0231068	MNK1, IC₅₀: 8 nM	MNK2, IC₅₀: 7 nM
NUCC-0200808	MNK1	MNK2

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