2. MAPK/ERK Pathway Cell Cycle/DNA Damage Apoptosis
  3. MNK Eukaryotic Initiation Factor (eIF) Apoptosis
  4. EB1

EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation.

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EB1 Chemical Structure

EB1 Chemical Structure

CAS No. : 42951-68-8

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EB1 Related Antibodies

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Description

EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation[1][2].

IC50 & Target[1]

MNK1

0.69 μM (IC50)

MNK2

9.4 μM (IC50)

eIF4E

 

In Vitro

EB1 (1.3-40 μM; 24 hr) inhibits the phosphorylation of eIF4E dose-dependently[1].
EB1 (2.5-40 μM; 72 hr) shows dose-dependent cytotoxicity on tumor cells, and induces apoptosis[1].
EB1 (5 μM, 10 μM, and 20 μM; 24 hr) acts directly on MNK kinases without perturbing activating upstream signaling, such as activation of p38 (p-p38) and phosphorylation of its downstream effector HSP27[1].
EB1 (compound 14) inhibits the growth of HepG2 and MCF-7 cancer cells with IC50s of 0.74 μM and 5.18 μM, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EB1 Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells
Concentration: 1.3 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 24 hours
Result: Blocked the phosphorylation of eIF4E in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells
Concentration: 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 72 hours
Result: Increased the percentage of apoptosis cells among tumor cells.
Molecular Weight

286.33

Formula

C18H14N4
CAS No.
SMILES

NC1=NNC2=C1C(C3=CC=CC=C3)=CC(C4=CC=CC=C4)=N2
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Purity & Documentation
References
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EB1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EB142951-68-8EB 1EB-1MNKEukaryotic Initiation Factor (eIF)ApoptosisMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseInhibitorinhibitorinhibit

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