42951-68-8
42951-68-8
Chemical Structure
EB1
- CAS No.: 42951-68-8
- Formula:C18H14N4
- Molecular Weight:286.33
IUPAC Name: 4,6-diphenyl-1H-pyrazolo[3,4-b]pyridin-3-amine
InChIKey: NGNHXYCLUMQSKR-UHFFFAOYSA-N
SMILES: NC1=NNC2=C1C(C3=CC=CC=C3)=CC(C4=CC=CC=C4)=N2
Biological Activity: EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EB1 | 99.91% | EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation. | ||||||||||||||||||||
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References
- [1]. Bou-Petit E, et al. Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor. J Med Chem. 2022 Apr 28;65(8):6070-6087. [Content Brief]
- [2]. Aboukhatwa SM, et al. Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition. Bioorg Chem. 2022 Dec;129:106126. [Content Brief]
Keywords
