10,10-Difluoro TXA2
10,10-Difluoro TXA2 (10,10-Difluorothromboxane A2; F2-TXA2) is a thromboxane A2/TP receptor agonist and induces platelet aggregation. 10,10-Difluoro TXA2 activates platelet α and vascular τ thromboxane/prostaglandin receptors, acts as a full agonist in platelet and vascular experiments, and promotes platelet activation, hemostasis, and smooth muscle contraction. 10,10-Difluoro TXA2 induces 12/15-LOX protein through mTOR/4EBP1/eIF4E-dependent translation and downstream PKCθ activation. 10,10-Difluoro TXA2 can be used for research on cardiovascular diseases.
For research use only. We do not sell to patients.
- CAS No.: 121573-36-2
- Formula: C20H30F2O5
- Molecular Weight:388.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
|
TXA2 |
TP |
mTOR |
4EBP1 |
eIF4E |
12-LOX |
15-LOX |
PKCθ |
In Vitro
10,10-Difluoro TXA2 (log −10-−4 M) induces only weak integrin αIIbβ3 activation in human platelets[1].
10,10-Difluoro TXA2 (10-10000 nM) induces mouse PRP aggregation with near-maximal effect at 1 μM, and the response is reduced in 12/15-LOX−/− platelets[2].
10,10-Difluoro TXA2 (1 μM; 10-30 min) activates PKCθ in WT mouse platelets, and this activation is dependent on 12/15-LOX[2].
10,10-Difluoro TXA2 (5 nM-5 μM; 1 min) is a full agonist for washed human platelet aggregation with EC50 36 nM[3].
10,10-Difluoro TXA2 (30 min) binds the platelet TXA2/PGH2 receptor with Kd 100 nM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 121573-36-2
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Molecular Weight 388.45
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Formula C20H30F2O5
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SMILES
OC(CCC/C=C\C[C@H]1[C@]2([H])C(F)([C@@](O[C@@H]1/C=C/[C@@H](O)CCCCC)([H])O2)F)=O
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Synonyms
10,10-Difluorothromboxane A2; F2-TXA2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
10,10-Difluoro TXA2 Related Classifications
HY-189078 Related Classifications
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Keywords
- 10,10-Difluoro TXA2
- 121573-36-2
- 10,10-Difluorothromboxane A2
- F2-TXA2
- Prostaglandin Receptor
- Platelet-activating Factor Receptor (PAFR)
- mTOR
- Eukaryotic Initiation Factor (eIF)
- PKC
- Lipoxygenase
- Mammalian target of Rapamycin
- Protein kinase C
- LOX
- 12/15-lipoxygenase
- PKCθ
- TP receptor palmitoylation
- cardiovascular disease
- integrin αIIbβ3
- mTOR/4EBP1/eIF4E-dependent translation
- platelet activation
- platelet aggregation
- thromboxane A2 receptor
- xanthine oxidase
- Inhibitor
- inhibitor
- inhibit