121573-36-2
Chemical Structure
10,10-Difluoro TXA2
Synonym(s): 10,10-Difluorothromboxane A2; F2-TXA2
- CAS. Nr.: 121573-36-2
- Formula:C20H30F2O5
- Molecular Weight:388.45
InChIKey: GJCWJHMKKPOZIY-LXBYMMDKSA-N
SMILES: OC(CCC/C=C\C[C@H]1[C@]2([H])C(F)([C@@](O[C@@H]1/C=C/[C@@H](O)CCCCC)([H])O2)F)=O
Biological Activity: 10,10-Difluoro TXA2 (10,10-Difluorothromboxane A2; F2-TXA2) is a thromboxane A2/TP receptor agonist and induces platelet aggregation. 10,10-Difluoro TXA2 activates platelet α and vascular τ thromboxane/prostaglandin receptors, acts as a full agonist in platelet and vascular experiments, and promotes platelet activation, hemostasis, and smooth muscle contraction. 10,10-Difluoro TXA2 induces 12/15-LOX protein through mTOR/4EBP1/eIF4E-dependent translation and downstream PKCθ activation. 10,10-Difluoro TXA2 can be used for research on cardiovascular diseases[1].
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10,10-Difluoro TXA2 | 10,10-Difluoro TXA2 (10,10-Difluorothromboxane A2; F2-TXA2) is a thromboxane A2/TP receptor agonist and induces platelet aggregation. 10,10-Difluoro TXA2 activates platelet α and vascular τ thromboxane/prostaglandin receptors, acts as a full agonist in platelet and vascular experiments, and promotes platelet activation, hemostasis, and smooth muscle contraction. 10,10-Difluoro TXA2 induces 12/15-LOX protein through mTOR/4EBP1/eIF4E-dependent translation and downstream PKCθ activation. 10,10-Difluoro TXA2 can be used for research on cardiovascular diseases. | |||||||||||||||||||||
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