1. MAPK/ERK Pathway Immunology/Inflammation
  2. MNK PD-1/PD-L1
  3. Tomivosertib hydrochloride

Tomivosertib hydrochloride  (Synonyms: eFT508 hydrochloride)

Cat. No.: HY-100022A
Handling Instructions

Tomivosertib hydrochlorideis a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib hydrochloride treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines. Tomivosertib hydrochloride also dramatically downregulates PD-L1 protein abundance.

For research use only. We do not sell to patients.

Tomivosertib hydrochloride Chemical Structure

Tomivosertib hydrochloride Chemical Structure

CAS No. : 1849590-02-8

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Top Publications Citing Use of Products

    Tomivosertib hydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2021 Feb 9.  [Abstract]

    Protein levels of eIF4E and MCL1 in LPS141 and MESSA cells upon treatment with eFT508 (30 μM, 24 h). The result indicates a inhibition of p-4E at 30 μM.

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    Description

    Tomivosertib hydrochlorideis a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib hydrochloride treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines[1]. Tomivosertib hydrochloride also dramatically downregulates PD-L1 protein abundance[2].

    IC50 & Target

    IC50: 1-2 nM (MNK1), 1-2 nM (MNK2)[1]

    Molecular Weight

    376.84

    Formula

    C17H21ClN6O2

    CAS No.
    SMILES

    O=C(C1=C(C)C=C(NC2=NC=NC(N)=C2)C(N13)=O)NC43CCCCC4.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
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    Tomivosertib hydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Tomivosertib hydrochloride
    Cat. No.:
    HY-100022A
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