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Tomivosertib hydrochloride

(Synonyms: eFT508 hydrochloride)
17 Cited Publications
고객리뷰

Based on 17 publication(s) in Google Scholar

Tomivosertib hydrochlorideis a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib hydrochloride treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines. Tomivosertib hydrochloride also dramatically downregulates PD-L1 protein abundance.

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  • CAS No.: 1849590-02-8
  • 화학식: C17H21ClN6O2
  • 분자량:376.84
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Tomivosertib hydrochloride Chemical Structure
    Tomivosertib hydrochloride Chemical Structure
  • Experimental Validation Results for Tomivosertib hydrochloride
  • Experimental Validation Results for Tomivosertib hydrochloride
  • Experimental Validation Results for Tomivosertib hydrochloride
  • Experimental Validation Results for Tomivosertib hydrochloride
  • Experimental Validation Results for Tomivosertib hydrochloride
CAS No.: 1849590-02-8
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  • Tomivosertib hydrochloride Chemical Structure
    Tomivosertib hydrochloride Chemical Structure
    1/16
  • 1/16

    Tomivosertib hydrochloride purchased from MedChemExpress. Usage Cited in: Brain. 2024 Sep 3;147(9):2991-2997. [Abstract]

    Customer Validation
     MNK inhibition with eFT508 (Tomivosertib: 25 nM) rapidly decreases phosphorylated eIF4E in human dorsal root ganglion neurons. Representative enlarged images of p-eIF4E immunostaining (red) and neuronal marker, peripherin (blue).

  • 1/16

    Tomivosertib hydrochloride purchased from MedChemExpress. Usage Cited in: Brain. 2024 Sep 3;147(9):2991-2997. [Abstract]

    Customer Validation
     Treatment with eFT508 (Tomivosertib: 25 nM) reverses spontaneous activity in human dorsal root ganglion neurons associated with painful dermatomes.

  • 1/16

    Tomivosertib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2022 Sep;18(9):942-953. [Abstract]

    Customer Validation
     Immunoblot analysis was performed on PANC-1 cell lysates to detect the expression of phosphorylated eIF4E (Ser 209; p-eIF4E), total eIF4E, and actin. These cells were treated with DMSO, CID661578, cercariaein, CGP57380, or eFT508 (Tomivosertib: 40 μM) for 6 hours.

  • 1/16

    Tomivosertib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2022 Sep;18(9):942-953. [Abstract]

    Customer Validation
     Six-day-old zebrafish larvae underwent β-cell ablation and were treated with DMSO, CID661578, eFT508, or a combination of CID661578 and eFT508 (Tomivosertib: 10 μM) for 48 hours. The number of β-cells was then quantitatively analyzed.

  • 1/16

    Tomivosertib hydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2021 Mar;40(10):1851-1867. [Abstract]

    Customer Validation
     Protein levels of eIF4E and MCL1 in LPS141 and MESSA cells upon treatment with eFT508 (30 μM, 24 h). The result indicates a inhibition of p-4E at 30 μM.

  • Tomivosertib hydrochloride