1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)

Briciclib (Synonyms: ON 014185)

Cat. No.: HY-16366 Purity: 99.15%
Handling Instructions

Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.

For research use only. We do not sell to patients.
Briciclib Chemical Structure

Briciclib Chemical Structure

CAS No. : 865783-99-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 438 In-stock
1 mg USD 180 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Related Small Molecules:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.

IC50 & Target

eIF4E[1]

In Vitro

Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1].

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1078 mL 10.5392 mL 21.0784 mL
5 mM 0.4216 mL 2.1078 mL 4.2157 mL
10 mM 0.2108 mL 1.0539 mL 2.1078 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

474.42

Formula

C₁₉H₂₃O₁₀PS

CAS No.

865783-99-9

SMILES

O=S(CC1=CC(OP(O)(O)=O)=C(OC)C=C1)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Briciclib
Cat. No.:
HY-16366
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