1. Cell Cycle/DNA Damage
    Autophagy
  2. Eukaryotic Initiation Factor (eIF)
    Autophagy
  3. Briciclib

Briciclib (Synonyms: ON 014185)

Cat. No.: HY-16366 Purity: 99.65%
Handling Instructions

Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.

For research use only. We do not sell to patients.

Briciclib Chemical Structure

Briciclib Chemical Structure

CAS No. : 865783-99-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 146 In-stock
Estimated Time of Arrival: December 31
1 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 620 In-stock
Estimated Time of Arrival: December 31
100 mg USD 920 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Briciclib:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.

IC50 & Target

eIF4E[1]

In Vitro

Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1].

Clinical Trial
Molecular Weight

474.42

Formula

C₁₉H₂₃O₁₀PS

CAS No.

865783-99-9

SMILES

O=S(CC1=CC(OP(O)(O)=O)=C(OC)C=C1)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (65.34 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1078 mL 10.5392 mL 21.0784 mL
5 mM 0.4216 mL 2.1078 mL 4.2157 mL
10 mM 0.2108 mL 1.0539 mL 2.1078 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.65%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Briciclib
Cat. No.:
HY-16366
Quantity: