1. Cell Cycle/DNA Damage
  2. CDK

ON-013100 

Cat. No.: HY-112822
Handling Instructions

ON-013100, an antineoplastic drug, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.

For research use only. We do not sell to patients.

ON-013100 Chemical Structure

ON-013100 Chemical Structure

CAS No. : 865783-95-5

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1 mg USD 90 Get quote
5 mg USD 140 Get quote
10 mg USD 220 Get quote
50 mg USD 620 Get quote
100 mg USD 920 Get quote

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Other In-stock Forms of ON-013100:

Other Forms of ON-013100:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

ON-013100, an antineoplastic drug, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.

IC50 & Target[1]

Cdk4/cyclin D1

 

In Vitro

ON-013100 induces apoptosis, and has activity against most human cancer cell lines in vitro. ON013100 significantly alters the cell cycle profile, dramatically increasing the number of cells in G2/M phase. Treatment of the cells with even 0.1 μM of ON013100 results in an arrest of the G2/M phase of the cell cycle[2]. ON 013100 inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at a nanomolar concentration (ON 013100 GI50=6.7-11.2 nM) [3].

Solvent & Solubility
In Vitro: 

H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5352 mL 12.6762 mL 25.3524 mL
5 mM 0.5070 mL 2.5352 mL 5.0705 mL
10 mM 0.2535 mL 1.2676 mL 2.5352 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

394.44

Formula

C₁₉H₂₂O₇S

CAS No.

865783-95-5

SMILES

OC1=CC(CS(=O)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O)=CC=C1OC

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ON-013100
Cat. No.:
HY-112822
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ON-013100

Cat. No.: HY-112822