1. Cell Cycle/DNA Damage
  2. CDK
  3. ON-013100

ON-013100 

Cat. No.: HY-112822
Handling Instructions

ON-013100, an antineoplastic drug, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.

For research use only. We do not sell to patients.

ON-013100 Chemical Structure

ON-013100 Chemical Structure

CAS No. : 865783-95-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
1 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 620 Get quote
100 mg USD 920 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Description

ON-013100, an antineoplastic drug, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.

IC50 & Target[1]

Cdk4/cyclin D1

 

In Vitro

ON-013100 induces apoptosis, and has activity against most human cancer cell lines in vitro. ON013100 significantly alters the cell cycle profile, dramatically increasing the number of cells in G2/M phase. Treatment of the cells with even 0.1 μM of ON013100 results in an arrest of the G2/M phase of the cell cycle[2]. ON 013100 inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at a nanomolar concentration (ON 013100 GI50=6.7-11.2 nM) [3].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

394.44

Formula

C₁₉H₂₂O₇S

CAS No.

865783-95-5

SMILES

OC1=CC(CS(=O)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O)=CC=C1OC

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ON-013100
Cat. No.:
HY-112822
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ON-013100

Cat. No.: HY-112822