ZFP42 - ZFP42 zinc finger protein Gene

Also Known as REX1; REX-1; ZNF754; zfp-42

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 132625

About ZFP42

Cytogenetic location: 4q35.2 Genomic coordinates (GRCh38): 4:187,995,771-188,005,246 (from NCBI)

This gene has 3 transcripts (splice variants), 75 orthologues and 2 paralogues. Biased expression in testis (RPKM 1.0), placenta (RPKM 0.5) and 1 other tissue.

Summary

Enables sequence-specific double-stranded DNA binding activity. Involved in female gonad development and male gonad development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZFP42 Products (2)

mRNA Protein Name
NM_001304358.2 NP_001291287.1 zinc finger protein 42 homolog
NM_174900.5 NP_777560.2 zinc finger protein 42 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in female gonad development IEP
IEP: Inferred from expression pattern
18281244 GOA
involved in male gonad development IEP
IEP: Inferred from expression pattern
18281244 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16344273 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFP42 Protein Structure

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (189 - 212)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (232 - 257)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (261 - 286)

  • 0
  • 100
  • 200
  • 310 a.a.
Protein Preferred Names Protein Names

zinc finger protein 42 homolog

  • REX1 transcription factor

ZFP42 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZFP42 Q96MM3 LHX2 Homo sapiens P50458
Y2H Array
32296183
Intra
ZFP42 Q96MM3 LHX2 Homo sapiens P50458
Y2H Prey Pooling
32296183
Intra
ZFP42 Q96MM3 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
ZFP42 Q96MM3 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
ZFP42 Q96MM3 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
ZFP42 Q96MM3 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
ZFP42 Q96MM3 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra
ZFP42 Q96MM3 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra
ZFP42 Q96MM3 SUMO1 Homo sapiens P63165
Y2H Array
32296183
Intra
ZFP42 Q96MM3 SUMO1 Homo sapiens P63165
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

ZFP42 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84736 ZFP42 Antibody (YA4433) WB, IHC-P, FC, ELISA Human, Mouse
HY-P84736A ZFP42 Antibody (YA4433)(PBS only) WB, IHC-P, FC, ELISA Human, Mouse

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 7

  • IBD7
Germ Cell And Embryonal Cancer

  • Germ Cell And Embryonal Neoplasm
Spermatocytoma

  • Spermatocytic Seminoma
Arthrogryposis, Distal, Type 1a

  • Distal Arthrogryposis Type 1

  • Digitotalar Dysmorphism

  • DA1A

  • Da1

  • Amcd1

  • Arthrogryposis, Distal, Type 2b4

  • Distal Arthrogryposis Type 1a

  • Arthrogryposis, Distal, Type 1

  • Arthrogryposis Multiplex Congenita Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal, Type I

  • Distal Arthrogryposis Type 1b

  • Arthrogryposis, Distal, 1a

  • Amc

  • Arthrogryposis Multiplex Congenita

  • Arthrogryposis, Distal, 2b4

  • DA2B4

  • Arthrogryposis Multiplex Congenita, Distal, Type 1

  • Arthrogryposis
Germ Cell Cancer

  • Malignant Germ Cell Tumor

  • Neoplasms, Germ Cell And Embryonal

  • Germ Cell Neoplasm

  • Germ Cell Tumour

  • Malignant Tumor Of The Germ Cell

  • Neoplasms Germ Cell

  • Malignant Germ Cell Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16043 ZFP42 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZFP42 MGD MGI:99187
Macaca mulatta ZFP42 VGNC VGNC:107210
Rattus norvegicus ZFP42 RGD RGD:2319133
Canis familiaris ZFP42 VGNC VGNC:53510
Felis catus ZFP42 VGNC VGNC:107479
Bos taurus ZFP42 VGNC VGNC:37164
Others ZFP42 NCBI