CBX4 - chromobox 4 Gene

Homo sapiens

Also known as PC2; NBP16

Gene ID: 8535 | Gene type: protein coding

About CBX4

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,833,156-79,839,440 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 8 paralogues. Broad expression in bone marrow (RPKM 17.4), spleen (RPKM 5.9) and 24 other tissues.

Summary

Enables SUMO binding activity; SUMO ligase activity; and Enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

CBX4 Products(1)

mRNA	Protein	Name
NM_003655.3	NP_003646.2	E3 SUMO-protein ligase CBX4

CBX4 Protein Structure

Chromo

0
100
200
300
400
500
560 a.a.

Protein Preferred Names

Protein Names

E3 SUMO-protein ligase CBX4

NS5ATP1-binding protein 16

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02011	CBX4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CBX4	RGD	RGD:1587243
Canis familiaris	CBX4	VGNC	VGNC:54929
Macaca mulatta	CBX4	VGNC	VGNC:70558
Mus musculus	CBX4	MGD	MGI:1195985
Felis catus	CBX4	VGNC	VGNC:98768
Bos taurus	CBX4	VGNC	VGNC:55784