CBX4 - chromobox 4 Gene

Also Known as PC2; NBP16

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8535

About CBX4

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,833,156-79,839,440 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 8 paralogues. Broad expression in bone marrow (RPKM 17.4), spleen (RPKM 5.9) and 24 other tissues.

Summary

Enables SUMO binding activity; SUMO Ligase activity; and enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

CBX4 Products (1)

mRNA Protein Name
NM_003655.3 NP_003646.2 E3 SUMO-protein ligase CBX4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SUMO binding IDA
IDA: Inferred from direct assay
20176810 GOA
enables SUMO ligase activity IDA
IDA: Inferred from direct assay
27068747 GOA
enables SUMO transferase activity EXP
EXP: Inferred from Experiment
12679040 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
17087506 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18567530 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21282530 GOA
Cellular Component GO Annotation Evidence References Source
part of PRC1 complex IDA
IDA: Inferred from direct assay
12167701 GOA
part of PcG protein complex IDA
IDA: Inferred from direct assay
21282530 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9367786 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBX4 Protein Structure

Chromo

Chromo: Chromo (CHRromatin Organisation MOdifier) domain (11 - 60)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 560 a.a.
Protein Preferred Names Protein Names

E3 SUMO-protein ligase CBX4

  • NS5ATP1-binding protein 16

CBX4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CBX4 O00257 BMI1 Homo sapiens P35226
Anti Tag CoIP
26496610
Intra
CBX4 O00257 BMI1 Homo sapiens P35226
TAP
27705803
Intra
CBX4 O00257 BMI1 Homo sapiens P35226
Anti Bait CoIP
22078878
Intra
CBX4 O00257 YWHAB Homo sapiens P31946
Anti Bait CoIP
22078878
Intra
CBX4 O00257 HIF1A Homo sapiens Q16665
Anti Tag CoIP
24434214
Intra
CBX4 O00257 HIF1A Homo sapiens Q16665
CH-IP
24434214
Intra
CBX4 O00257 HIF1A Homo sapiens Q16665
Pull Down
24434214
Intra
CBX4 O00257 CBX8 Homo sapiens Q9HC52
Anti Bait CoIP
17332741
Intra
CBX4 O00257 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
26496610
Intra
CBX4 O00257 RNF2 Homo sapiens Q99496
TAP
27705803
Intra
CBX4 O00257 RNF2 Homo sapiens Q99496
Anti Tag CoIP
26496610
Intra
CBX4 O00257 SUMO1 Homo sapiens P63165
Confocal
20098713
Intra
CBX4 O00257 SUMO1 Homo sapiens P63165
Pull Down
20098713
Intra
CBX4 O00257 CTBP1 Homo sapiens Q13363
Anti Tag CoIP
20098713
Intra
CBX4 O00257 CTBP1 Homo sapiens Q13363
Confocal
20098713
Cross: Cross-species interaction Intra: Intraspecies interaction

CBX4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82745 CBX4 Antibody (YA2490) WB Human, Mouse, Rat
HY-P83790 CBX4 Antibody (YA3487) IHC-P, FC, ELISA Human
HY-P83790A CBX4 Antibody (YA3487)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15476 VU 0364439 99.42% Unkown
HY-178918 XZA-1 99.59% Unkown
HY-RS02011 CBX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181089 CBX2-IN-1 Inhibitor / Unkown
HY-RS20702 Cbx4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27213 Cbx4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CBX4 RGD RGD:1587243
Canis familiaris CBX4 VGNC VGNC:54929
Macaca mulatta CBX4 VGNC VGNC:70558
Mus musculus CBX4 MGD MGI:1195985
Felis catus CBX4 VGNC VGNC:98768
Bos taurus CBX4 VGNC VGNC:55784
Others CBX4 NCBI