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RNF2 - ring finger protein 2 Gene

Also Known as BAP1; DING; BAP-1; HIPI3; RING2; LUSYAM; RING1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6045

About RNF2

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:185,045,558-185,102,603 (from NCBI)

This gene has 4 transcripts (splice variants), 223 orthologues, 7 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 7.8), placenta (RPKM 6.0) and 25 other tissues.

Summary

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with Huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin Ligase activity. [provided by RefSeq, Jul 2008]

RNF2 Products (1)

mRNA	Protein	Name
NM_007212.4	NP_009143.1	E3 ubiquitin-protein ligase RING2

RNF2 Protein Structure

zf-C3HC4

0
100
200
300
336 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RING2	HIP2-interacting protein 3

RNF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF2	Q99496	PCGF6	Homo sapiens	Q9BYE7	TAP	24981860
Intra	RNF2	Q99496	PCGF6	Homo sapiens	Q9BYE7	Anti Tag CoIP	26496610
Intra	RNF2	Q99496	PCGF6	Homo sapiens	Q9BYE7	TAP	27705803
Intra	RNF2	Q99496	ABCB1	Homo sapiens	P08183	Y2H	17088979
Intra	RNF2	Q99496	PCGF3	Homo sapiens	Q3KNV8-2	Y2H Array	32296183
Intra	RNF2	Q99496	UBE2E2	Homo sapiens	Q96LR5	Y2H Array	19549727
Intra	RNF2	Q99496	PCGF2	Homo sapiens	P35227	Anti Tag CoIP	19636380
Intra	RNF2	Q99496	PCGF2	Homo sapiens	P35227	TAP	24981860
Intra	RNF2	Q99496	PCGF2	Homo sapiens	P35227	TAP	27705803
Intra	RNF2	Q99496	PCGF2	Homo sapiens	P35227	Y2H Array	22493164
Intra	RNF2	Q99496	PCGF3	Homo sapiens	Q3KNV8	TAP	27705803
Intra	RNF2	Q99496	PCGF3	Homo sapiens	Q3KNV8	TAP	24981860
Intra	RNF2	Q99496	PCGF3	Homo sapiens	Q3KNV8	Anti Tag CoIP	22493164
Intra	RNF2	Q99496	BMI1	Homo sapiens	P35226	GMS	21772249
Intra	RNF2	Q99496	BMI1	Homo sapiens	P35226	TAP	24981860
Intra	RNF2	Q99496	BMI1	Homo sapiens	P35226	TAP	27705803
Intra	RNF2	Q99496	BMI1	Homo sapiens	P35226	Pull Down	22902369
Intra	RNF2	Q99496	BMI1	Homo sapiens	P35226	Anti Tag CoIP	22493164
Intra	RNF2	Q99496	BMI1	Homo sapiens	P35226	X-Ray Diffraction	16710298
Intra	RNF2	Q99496	BMI1	Homo sapiens	P35226	Anti Tag CoIP	26496610
Intra	RNF2	Q99496	PCGF5	Homo sapiens	Q86SE9	TAP	24981860
Intra	RNF2	Q99496	PCGF5	Homo sapiens	Q86SE9	TAP	27705803
Intra	RNF2	Q99496	PCGF5	Homo sapiens	Q86SE9	Anti Tag CoIP	25519132
Intra	RNF2	Q99496	AUTS2	Homo sapiens	Q8WXX7	TAP	27705803
Intra	RNF2	Q99496	AUTS2	Homo sapiens	Q8WXX7	Anti Tag CoIP	25519132
Intra	RNF2	Q99496	USP7	Homo sapiens	Q93009	Pull Down	20601937
Intra	RNF2	Q99496	USP7	Homo sapiens	Q93009	Anti Tag CoIP	20601937
Intra	RNF2	Q99496	USP7	Homo sapiens	Q93009	Anti Tag CoIP	26496610
Intra	RNF2	Q99496	USP11	Homo sapiens	P51784	Pull Down	20601937
Intra	RNF2	Q99496	USP11	Homo sapiens	P51784	Anti Tag CoIP	20601937
Intra	RNF2	Q99496	CSNK2A1	Homo sapiens	P68400	TAP	27705803
Intra	RNF2	Q99496	CSNK2A1	Homo sapiens	P68400	Pull Down	21282530
Intra	RNF2	Q99496	CSNK2B	Homo sapiens	P67870	TAP	27705803
Intra	RNF2	Q99496	UBE2D3	Homo sapiens	P61077	Y2H Array	19549727
Intra	RNF2	Q99496	CBX7	Homo sapiens	O95931	X-Ray Diffraction	20696397
Intra	RNF2	Q99496	CBX7	Homo sapiens	O95931	Pull Down	20696397
Intra	RNF2	Q99496	CBX7	Homo sapiens	O95931	NMR	20696397
Intra	RNF2	Q99496	CBX7	Homo sapiens	O95931	Comig Non-Denat Gel	20696397
Intra	RNF2	Q99496	CBX7	Homo sapiens	O95931	TAP	27705803
Intra	RNF2	Q99496	CBX7	Homo sapiens	O95931	Pull Down	21282530
Intra	RNF2	Q99496	CBX7	Homo sapiens	O95931	Lambda Y2H	23523425
Intra	RNF2	Q99496	CBX7	Homo sapiens	O95931	Anti Tag CoIP	21282530
Intra	RNF2	Q99496	CBX7	Homo sapiens	O95931	Ion Exchange Chrom	20696397
Intra	RNF2	Q99496	CBX7	Homo sapiens	O95931	BiFC	18927235
Intra	RNF2	Q99496	CBX6	Homo sapiens	O95503	Pull Down	21282530
Intra	RNF2	Q99496	CBX6	Homo sapiens	O95503	BiFC	18927235
Intra	RNF2	Q99496	CBX6	Homo sapiens	O95503	TAP	27705803
Intra	RNF2	Q99496	CBX6	Homo sapiens	O95503	Anti Tag CoIP	21282530
Intra	RNF2	Q99496	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	RNF2	Q99496	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	RNF2	Q99496	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	RNF2	Q99496	CBX8	Homo sapiens	Q9HC52	Anti Tag CoIP	26496610
Intra	RNF2	Q99496	CBX8	Homo sapiens	Q9HC52	BiFC	18927235
Intra	RNF2	Q99496	CBX8	Homo sapiens	Q9HC52	TAP	27705803
Intra	RNF2	Q99496	CBX8	Homo sapiens	Q9HC52	Pull Down	21282530
Intra	RNF2	Q99496	CBX8	Homo sapiens	Q9HC52	Imaging	17332741
Intra	RNF2	Q99496	CBX4	Homo sapiens	O00257	Anti Tag CoIP	26496610
Intra	RNF2	Q99496	CBX4	Homo sapiens	O00257	TAP	27705803
Intra	RNF2	Q99496	CBX4	Homo sapiens	O00257	Y2H Pooling	16169070
Intra	RNF2	Q99496	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	32296183
Intra	RNF2	Q99496	PCGF1	Homo sapiens	Q9BSM1	Anti Tag CoIP	22493164
Intra	RNF2	Q99496	PCGF1	Homo sapiens	Q9BSM1	Y2H Array	22493164
Intra	RNF2	Q99496	PCGF1	Homo sapiens	Q9BSM1	Anti Tag CoIP	26496610
Intra	RNF2	Q99496	PCGF1	Homo sapiens	Q9BSM1	TAP	24981860
Intra	RNF2	Q99496	PCGF1	Homo sapiens	Q9BSM1	Validated Y2H	32296183
Intra	RNF2	Q99496	PCGF1	Homo sapiens	Q9BSM1	TAP	27705803
Intra	RNF2	Q99496	RING1	Homo sapiens	Q06587	Ion Exchange Chrom	15386022
Intra	RNF2	Q99496	RING1	Homo sapiens	Q06587	Anti Tag CoIP	26496610
Intra	RNF2	Q99496	RING1	Homo sapiens	Q06587	GMS	15386022
Intra	RNF2	Q99496	RYBP	Homo sapiens	Q8N488	Ion Exchange Chrom	20696397
Intra	RNF2	Q99496	RYBP	Homo sapiens	Q8N488	SPR	20696397
Intra	RNF2	Q99496	RYBP	Homo sapiens	Q8N488	X-Ray Diffraction	20696397
Intra	RNF2	Q99496	RYBP	Homo sapiens	Q8N488	Solution Sedimentation	20696397
Intra	RNF2	Q99496	RYBP	Homo sapiens	Q8N488	Pull Down	20696397
Intra	RNF2	Q99496	RYBP	Homo sapiens	Q8N488	TAP	27705803
Intra	RNF2	Q99496	RYBP	Homo sapiens	Q8N488	Pull Down	16943429
Intra	RNF2	Q99496	RYBP	Homo sapiens	Q8N488	Anti Tag CoIP	26496610
Intra	RNF2	Q99496	RYBP	Homo sapiens	Q8N488	NMR	20696397
Intra	RNF2	Q99496	KAT8	Homo sapiens	Q9H7Z6	Pull Down	15960975

Cross: Cross-species interaction Intra: Intraspecies interaction

RNF2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83585	RING2 Antibody (YA3330)	WB, IHC-P	Human
HY-P83585A	RING2 Antibody (YA3330)(PBS only)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Luo-Schoch-Yamamoto Syndrome	LUSYAM
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12074	RNF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19947	Rnf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26449	Rnf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RNF2	VGNC	VGNC:34046
Macaca mulatta	RNF2	VGNC	VGNC:100060
Canis familiaris	RNF2	VGNC	VGNC:45652
Mus musculus	RNF2	MGD	MGI:1101759
Rattus norvegicus	RNF2	RGD	RGD:1305491
Felis catus	RNF2	VGNC	VGNC:64688
Others	RNF2	NCBI