CSNK2B - casein kinase 2 beta Gene

Also Known as G5A; CK2B; CK2N; Ckb1; Ckb2; CSK2B; POBINDS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1460

About CSNK2B

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,666,080-31,670,067 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 262 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 91.5), skin (RPKM 69.4) and 25 other tissues.

Summary

This gene encodes the beta subunit of Casein Kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

CSNK2B Products (2)

mRNA	Protein	Name
NM_001282385.2	NP_001269314.1	casein kinase II subunit beta isoform 2
NM_001320.7	NP_001311.3	casein kinase II subunit beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19324893	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	25519132	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10094392	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10094392	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11984006	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	15723517	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	31341047	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	19233263	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adiponectin-activated signaling pathway	IDA IDA: Inferred from direct assay	19233263	GOA
involved in endothelial tube morphogenesis	IMP IMP: Inferred from mutant phenotype	19592636	GOA
involved in negative regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	19592636	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	28031292	GOA
involved in negative regulation of viral life cycle	IDA IDA: Inferred from direct assay	31341047	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	15723517	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	19592636	GOA
involved in positive regulation of activin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19592636	GOA
involved in symbiont-mediated disruption of host cell PML body	IDA IDA: Inferred from direct assay	20719947	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in PML body	IDA IDA: Inferred from direct assay	20719947	GOA
part of PcG protein complex	IDA IDA: Inferred from direct assay	21282530	GOA
located in chromatin	IDA IDA: Inferred from direct assay	31341047	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19233263	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21282530	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	19233263	GOA
part of protein kinase CK2 complex	IDA IDA: Inferred from direct assay	15723517	GOA
part of protein kinase CK2 complex	IPI IPI: Inferred from physical interaction	22506723	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSNK2B Protein Structure

CK_II_beta

0
100
200
215 a.a.

Protein Preferred Names	Protein Names
casein kinase II subunit beta	CK II beta

CSNK2B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CSNK2B	P67870	RPS6KA3	Homo sapiens	P51812	Anti Tag CoIP	33961781
Intra	CSNK2B	P67870	CST1	Homo sapiens	P01037	Y2H Array	32296183
Intra	CSNK2B	P67870	CST1	Homo sapiens	P01037	Y2H Prey Pooling	32296183
Intra	CSNK2B	P67870	TWF1	Homo sapiens	Q12792	Validated Y2H	32296183
Intra	CSNK2B	P67870	TWF1	Homo sapiens	Q12792	Y2H Array	32296183
Intra	CSNK2B	P67870	TWF1	Homo sapiens	Q12792	Y2H Prey Pooling	32296183
Intra	CSNK2B	P67870	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	CSNK2B	P67870	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
Intra	CSNK2B	P67870	NRF1	Homo sapiens	Q16656-4	Validated Y2H	32296183
Intra	CSNK2B	P67870	TFAP2D	Homo sapiens	Q7Z6R9	Validated Y2H	32296183
Intra	CSNK2B	P67870	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Cross	CSNK2B	P67870	Cry1	Mus musculus	P97784	Y2H	23555304
Cross	CSNK2B	P67870	Cry1	Mus musculus	P97784	Pull Down	26562092
Intra	CSNK2B	P67870	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Prey Pooling	32296183
Intra	CSNK2B	P67870	FAM86C1P	Homo sapiens	Q9NVL1-2	Validated Y2H	32296183
Intra	CSNK2B	P67870	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Array	32296183
Intra	CSNK2B	P67870	ZNF19	Homo sapiens	P17023	Y2H Prey Pooling	32296183
Intra	CSNK2B	P67870	ZNF19	Homo sapiens	P17023	Y2H Array	32296183
Intra	CSNK2B	P67870	RPS6KA2	Homo sapiens	Q15349	Anti Tag CoIP	33961781
Intra	CSNK2B	P67870	MGC50722	Homo sapiens	Q8IVT4	Validated Y2H	32296183
Intra	CSNK2B	P67870	PTTG2	Homo sapiens	Q9NZH5-2	Validated Y2H	32296183
Intra	CSNK2B	P67870	PTTG2	Homo sapiens	Q9NZH5-2	Y2H Array	32296183
Intra	CSNK2B	P67870	PTTG2	Homo sapiens	Q9NZH5-2	Y2H Prey Pooling	32296183
Intra	CSNK2B	P67870	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	21968188
Intra	CSNK2B	P67870	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	CSNK2B	P67870	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	CSNK2B	P67870	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	CSNK2B	P67870	PACS1	Homo sapiens	Q6VY07	Pull Down	16977309
Intra	CSNK2B	P67870	PIMREG	Homo sapiens	Q9BSJ6	Y2H Array	32296183
Intra	CSNK2B	P67870	PIMREG	Homo sapiens	Q9BSJ6	Validated Y2H	32296183
Intra	CSNK2B	P67870	PIMREG	Homo sapiens	Q9BSJ6	Y2H Prey Pooling	32296183
Intra	CSNK2B	P67870	CSNK2A2	Homo sapiens	P19784	Y2H	19011756
Intra	CSNK2B	P67870	CSNK2A2	Homo sapiens	P19784	Anti Tag CoIP	33961781
Intra	CSNK2B	P67870	CSNK2A2	Homo sapiens	P19784	Y2H	23555304
Intra	CSNK2B	P67870	CSNK2A2	Homo sapiens	P19784	Y2H	14667819
Intra	CSNK2B	P67870	CSNK2A2	Homo sapiens	P19784	Y2H	10094392
Intra	CSNK2B	P67870	CSNK2A2	Homo sapiens	P19784	Anti Tag CoIP	35271311
Intra	CSNK2B	P67870	CSNK2A1	Homo sapiens	P68400	Pull Down	21282530
Intra	CSNK2B	P67870	CSNK2A1	Homo sapiens	P68400	Y2H	19011756
Intra	CSNK2B	P67870	CSNK2A1	Homo sapiens	P68400	Y2H	21988832
Intra	CSNK2B	P67870	CSNK2A1	Homo sapiens	P68400	BRET	29997244
Intra	CSNK2B	P67870	CSNK2A1	Homo sapiens	P68400	Y2H	23555304
Intra	CSNK2B	P67870	CSNK2A1	Homo sapiens	P68400	Y2H	14667819
Intra	CSNK2B	P67870	CSNK2A1	Homo sapiens	P68400	Protein Kinase Assay	12769847
Intra	CSNK2B	P67870	CSNK2A1	Homo sapiens	P68400	Anti Bait CoIP	21968188
Intra	CSNK2B	P67870	PHRF1	Homo sapiens	Q9P1Y6	Anti Tag CoIP	33961781
Intra	CSNK2B	P67870	RBM39	Homo sapiens	Q14498	Validated Y2H	32296183
Intra	CSNK2B	P67870	INO80B	Homo sapiens	Q9C086	Validated Y2H	32296183
Intra	CSNK2B	P67870	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	35271311
Intra	CSNK2B	P67870	RNF2	Homo sapiens	Q99496	Pull Down	21282530
Intra	CSNK2B	P67870	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	33961781
Intra	CSNK2B	P67870	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	CSNK2B	P67870	RPS6KA5	Homo sapiens	O75582	Anti Tag CoIP	33961781
Intra	CSNK2B	P67870	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	CSNK2B	P67870	SELI	Homo sapiens	Q8WU57	Validated Y2H	32296183
Intra	CSNK2B	P67870	SELI	Homo sapiens	Q8WU57	Y2H Prey Pooling	32296183
Intra	CSNK2B	P67870	SELI	Homo sapiens	Q8WU57	Y2H Array	32296183
Cross	CSNK2B	P67870	Clock	Mus musculus	O08785	Y2H	23555304
Cross	CSNK2B	P67870	Clock	Mus musculus	O08785	Anti Tag CoIP	23555304
Intra	CSNK2B	P67870	NGDN	Homo sapiens	Q8NEJ9	Y2H Prey Pooling	32296183
Intra	CSNK2B	P67870	NGDN	Homo sapiens	Q8NEJ9	Validated Y2H	32296183
Intra	CSNK2B	P67870	NGDN	Homo sapiens	Q8NEJ9	Y2H Array	32296183
Cross	CSNK2B	P67870	Clip1	Rattus norvegicus	Q9JK25	Anti Bait CoIP	20664522

Cross: Cross-species interaction Intra: Intraspecies interaction

CSNK2B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80586	Casein Kinase 2 beta Antibody (YA563)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P80586A	Casein Kinase 2 beta Antibody (YA563)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Poirier-Bienvenu Neurodevelopmental Syndrome	POBINDS
Prognathism, Mandibular	Habsburg Jaw 'Habsburg Jaw' 'Hapsburg Jaw' Prognathism Mandibular Hapsburg Jaw Autosomal Dominant Prognathism
Filippi Syndrome	Scott Craniodigital Syndrome With Mental Retardation Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome FLPIS Scott Bryant Graham Syndrome Craniodigital-Intellectual Disability Syndrome Scott Craniodigital Syndrome Scott-Bryant-Graham Syndrome Syndactyly, Type I, With Microcephaly And Mental Retardation Syndactyly Type I With Microcephaly And Intellectual Disability Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly Craniodigital Syndrome With Intellectual Disability Craniodigital Syndrome-Intellectual Disability Syndrome Craniodigital Syndrome-Intellectual Disability, Scott Type Intellectual Disability-Craniodigital Syndrome
Autosomal Dominant Non-Syndromic Intellectual Disability
Enophthalmos
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Egg Allergy	Allergy To Eggs Allergies Egg Egg Hypersensitivity
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03253	CSNK2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21842	Csnk2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28358	Csnk2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CSNK2B	MGD	MGI:88548
Bos taurus	CSNK2B	VGNC	VGNC:53965
Rattus norvegicus	CSNK2B	RGD	RGD:619978
Felis catus	CSNK2B	VGNC	VGNC:102410
Others	CSNK2B	NCBI