PHRF1 - PHD and ring finger domains 1 Gene

Also Known as RNF221; PPP1R125

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57661

About PHRF1

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:576,470-612,222 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 206 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 9.2), spleen (RPKM 7.4) and 25 other tissues.

Summary

Predicted to enable RNA polymerase binding activity. Predicted to be involved in mRNA processing and transcription by RNA polymerase II. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

PHRF1 Products (4)

mRNA Protein Name
NM_001286581.2 NP_001273510.1 PHD and RING finger domain-containing protein 1 isoform 1
NM_001286582.2 NP_001273511.1 PHD and RING finger domain-containing protein 1 isoform 3
NM_001286583.2 NP_001273512.1 PHD and RING finger domain-containing protein 1 isoform 4
NM_020901.4 NP_065952.2 PHD and RING finger domain-containing protein 1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHRF1 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (107 - 147)

PHD

PHD: PHD-finger (185 - 231)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1649 a.a.
Protein Preferred Names Protein Names

PHD and RING finger domain-containing protein 1

  • CTD-binding SR-like protein rA9

PHRF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PHRF1 Q9P1Y6 CSNK2B Homo sapiens P67870
Y2H
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10454 PHRF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22728 Phrf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29242 Phrf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PHRF1 VGNC VGNC:32847
Mus musculus PHRF1 MGD MGI:2141847
Canis familiaris PHRF1 VGNC VGNC:44510
Rattus norvegicus PHRF1 RGD RGD:708360
Felis catus PHRF1 VGNC VGNC:64154
Macaca mulatta PHRF1 VGNC VGNC:75856
Others PHRF1 NCBI