NGDN - neuroguidin Gene

Also Known as NGD; LCP5; CANu1; lpd-2; C14orf120

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25983

About NGDN

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,469,703-23,478,826 (from NCBI)

This gene has 29 transcripts (splice variants), 185 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 17.4), ovary (RPKM 12.6) and 25 other tissues.

Summary

Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]

NGDN Products (2)

mRNA Protein Name
NM_001042635.2 NP_001036100.1 neuroguidin isoform 1
NM_015514.2 NP_056329.1 neuroguidin isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NGDN Protein Structure

Sas10_Utp3

Sas10_Utp3: Sas10/Utp3/C1D family (17 - 98)

  • 0
  • 100
  • 200
  • 300
  • 315 a.a.
Protein Preferred Names Protein Names

neuroguidin

  • EIF4E-binding protein

NGDN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NGDN Q8NEJ9 NOM1 Homo sapiens Q5C9Z4
Y2H Array
32296183
Intra
NGDN Q8NEJ9 NOM1 Homo sapiens Q5C9Z4
Y2H Prey Pooling
32296183
Intra
NGDN Q8NEJ9 AATF Homo sapiens Q9NY61
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09275 NGDN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NGDN MGD MGI:1916216
Canis familiaris NGDN VGNC VGNC:43794
Rattus norvegicus NGDN RGD RGD:1310211
Felis catus NGDN VGNC VGNC:63794
Bos taurus NGDN VGNC VGNC:32059
Macaca mulatta NGDN VGNC VGNC:75220
Others NGDN NCBI