NOM1 - nucleolar protein with MIF4G domain 1 Gene

Also Known as SGD1; C7orf3; PPP1R113

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64434

About NOM1

Cytogenetic location: 7q36.3 Genomic coordinates (GRCh38): 7:156,949,712-156,973,176 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 2.9), lymph node (RPKM 2.8) and 25 other tissues.

Summary

Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008]

NOM1 Products (2)

mRNA	Protein	Name
NM_001353366.2	NP_001340295.1	nucleolar MIF4G domain-containing protein 1 isoform 2
NM_138400.2	NP_612409.1	nucleolar MIF4G domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17965019	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleolus	IDA IDA: Inferred from direct assay	15715967	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOM1 Protein Structure

MIF4G

MA3

0
200
400
600
800
860 a.a.

Protein Preferred Names	Protein Names
nucleolar MIF4G domain-containing protein 1	SGD1 homolog

NOM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NOM1	Q5C9Z4	EIF4A3	Homo sapiens	P38919	Anti Tag CoIP	21576267
Intra	NOM1	Q5C9Z4	EIF4A3	Homo sapiens	P38919	Pull Down	21576267
Intra	NOM1	Q5C9Z4	NGDN	Homo sapiens	Q8NEJ9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neuronopathy, Distal Hereditary Motor, Type I	Dhmn1 Hmn I Distal Hereditary Motor Neuronopathy Type 1 Autosomal Dominant Distal Juvenile Spinal Muscular Atrophy Type 1 Neuronopathy, Distal Hereditary Motor, Type 1 HMN1 Neuropathy, Distal Hereditary Motor, Type I Spinal Muscular Atrophy, Distal, Juvenile, Autosomal Dominant, I Charcot-Marie-Tooth Disease, Spinal, I Distal Hereditary Motor Neuropathy Type I Spinal Charcot-Marie-Tooth Disease 1 Distal Hereditary Motor Neuropathy Type 1 Neuropathy, Motor, Distal, Hereditary, Type I
Acheiropody	Acheiropodia ACHP Acheiropody, Brazilian Type Horn-Kolb Syndrome Horn Kolb Syndrome Acheiropody Brazilian Type
Ovarian Mucinous Adenocarcinoma	Mucinous Carcinoma Of Ovary
Polydactyly	Non-Syndromic Polydactyly Polydactyly, Postaxial Postaxial Polydactyly Supernumerary Digit Extra Digits Hyperdactyly Polydactylia Polydactylism Supernumerary Digits

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09421	NOM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NOM1	VGNC	VGNC:81729
Mus musculus	NOM1	MGD	MGI:1861749
Rattus norvegicus	NOM1	RGD	RGD:1588109
Felis catus	NOM1	VGNC	VGNC:63855
Bos taurus	NOM1	VGNC	VGNC:32162
Others	NOM1	NCBI