EIF4A3 - eukaryotic translation initiation factor 4A3 Gene

Also Known as Fal1; RCPS; DDX48; MUK34; NUK34; NMP265; eIF4AIII; eIF4A-III; eIF-4A-III

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9775

About EIF4A3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:80,134,369-80,147,128 (from NCBI)

This gene has 9 transcripts (splice variants), 230 orthologues, 38 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 66.0), adrenal (RPKM 43.4) and 25 other tissues.

Summary

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two Other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]

EIF4A3 Products (2)

mRNA	Protein	Name
NM_001411099.1	NP_001398028.1	eukaryotic initiation factor 4A-III isoform 2
NM_014740.4	NP_055555.1	eukaryotic initiation factor 4A-III isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10523622	GOA
enables RNA helicase activity	IDA IDA: Inferred from direct assay	10523622	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	22961380	GOA
enables poly(A) binding	IDA IDA: Inferred from direct assay	10523622	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10523622	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	24360810	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	29301961	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	10523622	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: Inferred from mutant phenotype	16209946	GOA
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	18423201	GOA
involved in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	19478851	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of U2-type catalytic step 1 spliceosome	IDA IDA: Inferred from direct assay	29301961	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10523622	GOA
part of exon-exon junction complex	IDA IDA: Inferred from direct assay	16601204	GOA
part of exon-exon junction complex	IPI IPI: Inferred from physical interaction	16931718	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29301961	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4A3 Protein Structure

DEAD

Helicase_C

0
100
200
300
411 a.a.

Protein Preferred Names	Protein Names
eukaryotic initiation factor 4A-III	ATP-dependent RNA helicase DDX48

EIF4A3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF4A3	P38919	PAX4	Homo sapiens	Q3KNR5	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	PAX4	Homo sapiens	Q3KNR5	Validated Y2H	32296183
Intra	EIF4A3	P38919	PAX4	Homo sapiens	Q3KNR5	Y2H Array	32296183
Intra	EIF4A3	P38919	CNKSR3	Homo sapiens	Q6P9H4	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	CNKSR3	Homo sapiens	Q6P9H4	Validated Y2H	32296183
Intra	EIF4A3	P38919	CNKSR3	Homo sapiens	Q6P9H4	Y2H Array	32296183
Intra	EIF4A3	P38919	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	EIF4A3	P38919	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	EIF4A3	P38919	CARD9	Homo sapiens	Q9H257-2	Y2H Array	32296183
Intra	EIF4A3	P38919	CARD9	Homo sapiens	Q9H257-2	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	EIF4A3	P38919	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	EIF4A3	P38919	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	EIF4A3	P38919	VRTN	Homo sapiens	Q9H8Y1	Validated Y2H	32296183
Intra	EIF4A3	P38919	VRTN	Homo sapiens	Q9H8Y1	Y2H Array	32296183
Intra	EIF4A3	P38919	VRTN	Homo sapiens	Q9H8Y1	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	EIF4A3	P38919	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	EIF4A3	P38919	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	ZXDB	Homo sapiens	P98169	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	ZXDB	Homo sapiens	P98169	Validated Y2H	32296183
Intra	EIF4A3	P38919	ZXDB	Homo sapiens	P98169	Y2H Array	32296183
Intra	EIF4A3	P38919	NOM1	Homo sapiens	Q5C9Z4	Anti Tag CoIP	35271311
Intra	EIF4A3	P38919	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	EIF4A3	P38919	MEOX1	Homo sapiens	P50221	Validated Y2H	32296183
Intra	EIF4A3	P38919	CASC3	Homo sapiens	O15234	TAP	16170325
Intra	EIF4A3	P38919	CASC3	Homo sapiens	O15234	Pull Down	14973490
Intra	EIF4A3	P38919	CASC3	Homo sapiens	O15234	Anti Tag CoIP	16209946
Intra	EIF4A3	P38919	CASC3	Homo sapiens	O15234	Anti Tag CoIP	16601204
Intra	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Crosslink	23084401
Intra	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	19478851
Intra	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	14730019
Intra	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	16601204
Intra	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Bait CoIP	23084401
Intra	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	GMS	23084401
Intra	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	23084401
Intra	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	TAP	18066079
Intra	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Bait CoIP	19410547
Intra	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	16209946
Intra	EIF4A3	P38919	POLR2G	Homo sapiens	P62487	Validated Y2H	32296183
Intra	EIF4A3	P38919	POLR2G	Homo sapiens	P62487	Y2H Array	32296183
Intra	EIF4A3	P38919	POLR2G	Homo sapiens	P62487	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	PRMT5	Homo sapiens	O14744	Y2H Array	32296183
Intra	EIF4A3	P38919	PRMT5	Homo sapiens	O14744	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	THRAP3	Homo sapiens	Q9Y2W1	Anti Tag CoIP	23084401
Intra	EIF4A3	P38919	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	PSMA1	Homo sapiens	P25786	Y2H Array	32296183
Intra	EIF4A3	P38919	DDX56	Homo sapiens	Q9NY93	Y2H Array	32296183
Intra	EIF4A3	P38919	DDX56	Homo sapiens	Q9NY93	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	DDX56	Homo sapiens	Q9NY93	Validated Y2H	32296183
Intra	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Bait CoIP	19410547
Intra	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Bait CoIP	23084401
Intra	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	GMS	23084401
Intra	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	CoIP	15361857
Intra	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	23084401
Intra	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	16601204
Intra	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	16209946
Intra	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	19478851
Intra	EIF4A3	P38919	CWC22	Homo sapiens	Q9HCG8	Pull Down	23236153
Intra	EIF4A3	P38919	CWC22	Homo sapiens	Q9HCG8	Anti Tag CoIP	23084401
Intra	EIF4A3	P38919	CWC22	Homo sapiens	Q9HCG8	Anti Tag CoIP	23236153
Intra	EIF4A3	P38919	CWC22	Homo sapiens	Q9HCG8	Anti Tag CoIP	22365833
Intra	EIF4A3	P38919	CWC22	Homo sapiens	Q9HCG8	BRET	29997244
Intra	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Anti Bait CoIP	23084401
Intra	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Crosslink	23084401
Intra	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	16209946
Intra	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	GMS	23084401
Intra	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	23084401
Intra	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Anti Bait CoIP	19410547
Intra	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	16601204
Intra	EIF4A3	P38919	CDCA7L	Homo sapiens	Q96GN5	Y2H Array	25416956
Intra	EIF4A3	P38919	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	EIF4A3	P38919	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	EIF4A3	P38919	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	EIF4A3	P38919	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	EIF4A3	P38919	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	32296183
Intra	EIF4A3	P38919	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	32296183
Intra	EIF4A3	P38919	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	EIF4A3	P38919	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	EIF4A3	P38919	EHMT2	Homo sapiens	Q96KQ7	Y2H Array	32296183
Intra	EIF4A3	P38919	EHMT2	Homo sapiens	Q96KQ7	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	EHMT2	Homo sapiens	Q96KQ7	Validated Y2H	32296183
Intra	EIF4A3	P38919	CCDC174	Homo sapiens	Q6PII3	Validated Y2H	32296183
Intra	EIF4A3	P38919	CCDC174	Homo sapiens	Q6PII3	Anti Tag CoIP	35271311
Intra	EIF4A3	P38919	CCDC174	Homo sapiens	Q6PII3	Y2H Array	32296183
Intra	EIF4A3	P38919	CCDC174	Homo sapiens	Q6PII3	Y2H Pooling	16189514
Intra	EIF4A3	P38919	CCDC174	Homo sapiens	Q6PII3	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	DRG2	Homo sapiens	P55039	Y2H Array	32296183
Intra	EIF4A3	P38919	DRG2	Homo sapiens	P55039	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	DRG2	Homo sapiens	P55039	Validated Y2H	32296183
Intra	EIF4A3	P38919	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	EIF4A3	P38919	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	EIF4A3	P38919	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	EIF4A3	P38919	PDCD4	Homo sapiens	Q53EL6	Validated Y2H	32296183
Intra	EIF4A3	P38919	PDCD4	Homo sapiens	Q53EL6	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

EIF4A3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82077	eIF4A3 Antibody (YA1822)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Robin Sequence With Cleft Mandible And Limb Anomalies	Richieri Costa Pereira Syndrome Richieri Costa-Pereira Syndrome Richieri-Costa-Pereira Syndrome RCPS Richieri-Costa And Pereira Form Of Acrofacial Dysostosis Short Stature, Robin Sequence, Cleft Mandible, Pre/Postaxial Hand Anomalies, And Clubfoot Short Stature-Pierre Robin Sequence-Cleft Mandible-Hand Anomalies Clubfoot Syndrome Short Stature-Pierre Robin Syndrome-Cleft Mandible-Hand Anomalies Clubfoot Syndrome Richieri-Costa And Pereira Syndrome
Mandibulofacial Dysostosis, Guion-Almeida Type	Mandibulofacial Dysostosis With Microcephaly Mandibulofacial Dysostosis-Microcephaly Syndrome MFDGA MFDM Mfdm Syndrome Growth And Mental Retardation, Mandibulofacial Dysostosis, Microcephaly, And Cleft Palate Growth Delay - Intellectual Disability - Mandibulofacial Dysostosis - Microcephaly - Cleft Palate Growth Delay-Intellectual Disability-Mandibulofacial Dysostosis-Microcephaly-Cleft Palate Syndrome Dysostosis, Mandibulofacial, Guion-Almeida Type
Acrofacial Dysostosis 1, Nager Type	Nager Syndrome Nager Acrofacial Dysostosis AFD1 Preaxial Acrofacial Dysostosis Mandibulofacial Dysostosis, Treacher Collins Type, With Limb Anomalies Afd, Nager Type Nager Acrofacial Dysostosis Syndrome Nafd Acrofacial Dysostosis, Nager Type Afd Preaxial Manibulofacial Dysostosis Split Hand Deformity-Mandibulofacial Dysostosis Preaxial Mandibulofacial Dysostosis Mandibulofacial Dysostosis With Preaxial Limb Anomalies Preaxial Acrodysostosis Afd Nager Type Mandibulofacial Dysostosis Treacher Collins Type With Limb Anomalies
Acrofacial Dysostosis
Burn-Mckeown Syndrome	Choanal Atresia-Hearing Loss-Cardiac Defects-Craniofacial Dysmorphism Syndrome Oculootofacial Dysplasia BMKS Oofd Bilateral Choanal Atresia, Cardiac Defects, Deafness, And Dysmorphic Appearance Choanal Atresia - Deafness - Cardiac Defects - Dysmorphism Syndrome Choanal Atresia Deafness Cardiac Defects Dysmorphism Oculo-Oto-Facial Dysplasia
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Thrombocytopenia-Absent Radius Syndrome	Tar Syndrome Radial Aplasia-Thrombocytopenia Syndrome Absent Radii And Thrombocytopenia TAR Chromosome 1q21.1 Deletion Syndrome, 200-Kb Thrombocytopenia Absent Radius Syndrome Thrombocytopenia Absent Radii Chromosome 1q21.1 Deletion Syndrome Thrombocytopenia With Absent Radii Syndrome Radial Aplasia-Amegakaryocytic Thrombocytopenia
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101513	eIF4A3-IN-1	Inhibitor	99.96%	Unkown
HY-101785	eIF4A3-IN-2	Inhibitor	99.70%	Unkown
HY-33838	eIF4A3-IN-8	Control	99.93%	Unkown
HY-148452	eIF4A3-IN-18	Inhibitor	99.58%	Unkown
HY-148446	eIF4A3-IN-12	Inhibitor	99.70%	Unkown
HY-43913	(R)-eIF4A3-IN-2		95.0%	Unkown
HY-139872	eIF4A3-IN-4	Inhibitor	99.8%	Unkown
HY-145309	eIF4E-IN-3	Inhibitor	/	Unkown
HY-148443	eIF4A3-IN-9	Inhibitor	99.71%	Unkown
HY-148444	eIF4A3-IN-10	Inhibitor	97.87%	Unkown
HY-148445	eIF4A3-IN-11	Inhibitor	99.24%	Unkown
HY-148447	eIF4A-IN-3	Inhibitor	99.92%	Unkown
HY-148448	eIF4A3-IN-14	Inhibitor	99.81%	Unkown
HY-148449	eIF4A3-IN-15	Inhibitor	/	Unkown
HY-148450	eIF4A3-IN-16	Inhibitor	99.96%	Unkown
HY-148451	eIF4A3-IN-17	Inhibitor	99.56%	Unkown
HY-145359	eIF4A3-IN-5	Inhibitor	/	Unkown
HY-145360	eIF4A3-IN-6	Inhibitor	/	Unkown
HY-145361	eIF4A3-IN-7	Inhibitor	/	Unkown
HY-RS04272	EIF4A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04276	EIF4E3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04279	EIF4EBP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04283	EIF4G3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17850	Eif4a3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24318	Eif4a3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EIF4A3	MGD	MGI:1923731
Macaca mulatta	EIF4A3	VGNC	VGNC:99146
Rattus norvegicus	EIF4A3	RGD	RGD:1591139
Bos taurus	EIF4A3	VGNC	VGNC:28406
Canis familiaris	EIF4A3	VGNC	VGNC:40281
Felis catus	EIF4A3	VGNC	VGNC:61789
Others	EIF4A3	NCBI