THRAP3 - thyroid hormone receptor associated protein 3 Gene

Also Known as BCLAF2; TRAP150

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9967

About THRAP3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:36,207,637-36,305,357 (from NCBI)

This gene has 4 transcripts (splice variants), 282 orthologues, 2 paralogues and is associated with 70 phenotypes. Ubiquitous expression in lymph node (RPKM 27.3), thyroid (RPKM 26.7) and 25 other tissues.

Summary

Enables phosphoprotein binding activity; Thyroid Hormone Receptor binding activity; and transcription coactivator activity. Involved in nuclear-transcribed mRNA catabolic process; positive regulation of circadian rhythm; and regulation of RNA metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of mediator complex. Colocalizes with exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

THRAP3 Products (3)

mRNA	Protein	Name
NM_001321471.2	NP_001308400.1	thyroid hormone receptor-associated protein 3 isoform 1
NM_001321473.2	NP_001308402.1	thyroid hormone receptor-associated protein 3 isoform 2
NM_005119.4	NP_005110.2	thyroid hormone receptor-associated protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	10198638	GOA
enables phosphoprotein binding	IDA IDA: Inferred from direct assay	20932480	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18596238	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12037571	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	10198638	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA stabilization	IMP IMP: Inferred from mutant phenotype	18794151	GOA
involved in nuclear-transcribed mRNA catabolic process	IDA IDA: Inferred from direct assay	20123736	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10198638	GOA
involved in positive regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	24043798	GOA
involved in positive regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	20123736	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12037571	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	20932480	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of exon-exon junction complex	IDA IDA: Inferred from direct assay	20123736	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	10198638	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	24100041	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	24100041	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10235267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THRAP3 Protein Structure

THRAP3_BCLAF1

0
200
400
600
800
955 a.a.

Protein Preferred Names	Protein Names
thyroid hormone receptor-associated protein 3	BCLAF1 and THRAP3 family member 2

THRAP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	THRAP3	Q9Y2W1	EIF4A3	Homo sapiens	P38919	Anti Tag CoIP	20123736
Intra	THRAP3	Q9Y2W1	SFPQ	Homo sapiens	P23246	Anti Bait CoIP	20932480
Intra	THRAP3	Q9Y2W1	SFPQ	Homo sapiens	P23246	Anti Tag CoIP	20932480
Intra	THRAP3	Q9Y2W1	NXF1	Homo sapiens	Q9UBU9	Anti Tag CoIP	20123736
Intra	THRAP3	Q9Y2W1	SNW1	Homo sapiens	Q13573	Anti Bait CoIP	18794151
Intra	THRAP3	Q9Y2W1	SNW1	Homo sapiens	Q13573	Anti Tag CoIP	18794151

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 2	MRD2 Autosomal Dominant Non-Syndromic Intellectual Disability 2 Autosomal Dominant Intellectual Developmental Disorder 2 Mental Retardation, Autosomal Dominant 2
Telangiectatic Osteogenic Sarcoma	Telangiectatic Osteosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14500	THRAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	THRAP3	VGNC	VGNC:100158
Canis familiaris	THRAP3	VGNC	VGNC:47354
Rattus norvegicus	THRAP3	RGD	RGD:1306129
Felis catus	THRAP3	VGNC	VGNC:66173
Bos taurus	THRAP3	VGNC	VGNC:35846
Mus musculus	THRAP3	MGD	MGI:2442637
Others	THRAP3	NCBI