1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)
  3. eIF4A3-IN-1

eIF4A3-IN-1 

Cat. No.: HY-101513
Handling Instructions

eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD.

For research use only. We do not sell to patients.

eIF4A3-IN-1 Chemical Structure

eIF4A3-IN-1 Chemical Structure

CAS No. : 2095486-67-0

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Description

eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD[1].

IC50 & Target

IC50: 0.2 μM (eIF4A3)[1]
Kd: 0.043 μM (eIF4A3)[1]

Molecular Weight

588.88

Formula

C₂₉H₂₃BrClN₅O₂

CAS No.

2095486-67-0

SMILES

ClC(C=C1)=CC=C1[[email protected]@H]2N(C(C3=CC=C(Br)C=C3)=O)CCN(C(C4=C(C)N(C5=CC=CC(C#N)=C5)N=C4)=O)C2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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eIF4A3-IN-1
Cat. No.:
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