CWC22 - CWC22 spliceosome associated protein homolog Gene

Also Known as NCM; fSAPb; EIF4GL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57703

About CWC22

Cytogenetic location: 2q31.3 Genomic coordinates (GRCh38): 2:179,944,876-180,007,297 (from NCBI)

This gene has 2 transcripts (splice variants), 229 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 9.1), thyroid (RPKM 8.8) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nuclear speck. Part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

CWC22 Products (5)

mRNA Protein Name
NM_001376029.1 NP_001362958.1 pre-mRNA-splicing factor CWC22 homolog isoform a
NM_001376030.1 NP_001362959.1 pre-mRNA-splicing factor CWC22 homolog isoform a
NM_001376032.1 NP_001362961.1 pre-mRNA-splicing factor CWC22 homolog isoform b
NM_001376033.1 NP_001362962.1 pre-mRNA-splicing factor CWC22 homolog isoform c
NM_020943.3 NP_065994.1 pre-mRNA-splicing factor CWC22 homolog isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
11991638 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
29360106 GOA
Cellular Component GO Annotation Evidence References Source
part of U2-type catalytic step 1 spliceosome IDA
IDA: Inferred from direct assay
29301961 GOA
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
29360106 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
22961380 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29360106 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
11991638 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CWC22 Protein Structure

MIF4G

MIF4G: MIF4G domain (164 - 345)

MA3

MA3: MA3 domain (455 - 561)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 908 a.a.
Protein Preferred Names Protein Names

pre-mRNA-splicing factor CWC22 homolog

  • CWC22 homolog, spliceosome-associated protein

CWC22 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CWC22 Q9HCG8 FRG1 Homo sapiens Q14331
Y2H
22365833
Intra
CWC22 Q9HCG8 PTPN21 Homo sapiens Q16825
Y2H Array
32296183
Intra
CWC22 Q9HCG8 PTPN21 Homo sapiens Q16825
Y2H Prey Pooling
32296183
Intra
CWC22 Q9HCG8 EIF4A3 Homo sapiens P38919
Y2H
22365833
Intra
CWC22 Q9HCG8 FAM32A Homo sapiens Q9Y421
Anti Tag CoIP
22365833
Intra
CWC22 Q9HCG8 KLHL2 Homo sapiens O95198
Y2H Prey Pooling
32296183
Intra
CWC22 Q9HCG8 KLHL2 Homo sapiens O95198
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hard Palate Cancer

  • Malignant Neoplasm Of Hard Palate

  • Malignant Tumor Of Hard Palate

  • Malignant Tumour Of Hard Palate
Mucinous Cystadenocarcinoma Of Pancreas

  • Pancreatic Mucinous Cystadenocarcinoma

  • Mucinous Cystadenocarcinoma Of The Pancreas

  • Pancreatic Colloid Cystadenocarcinoma
Pancreatic Cystadenocarcinoma

  • Cystadenocarcinoma Of Pancreas
Diabetic Polyneuropathy

  • Diabetes Mellitus With Polyneuropathy

  • Polyneuropathy In Diabetes

  • Diabetic Polyneuropathies

  • Diabetic Neuropathy Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03373 CWC22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CWC22 VGNC VGNC:61291
Canis familiaris CWC22 VGNC VGNC:39741
Macaca mulatta CWC22 VGNC VGNC:71604
Mus musculus CWC22 MGD MGI:2136773
Rattus norvegicus CWC22 RGD RGD:1565385
Bos taurus CWC22 VGNC VGNC:27841
Others CWC22 NCBI