1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)

eIF4A3-IN-2 

Cat. No.: HY-101785
Handling Instructions

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.

For research use only. We do not sell to patients.

eIF4A3-IN-2 Chemical Structure

eIF4A3-IN-2 Chemical Structure

CAS No. : 2095677-20-4

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.

IC50 & Target

IC50: 110 nM (eIF4A3)[1]

In Vitro

eIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay (NMD) activities[1].

Apoptosis Analysis[1]

Cell Line: HEK293T cells (transfected with the NMD reporter) luciferase assay
Concentration: 0.3, 1, 3, or 10 μM
Incubation Time: 3 or 6 h
Result: eIF4A3-IN-2 induces an approximately 3.2-fold increase in luciferase activity, indicating that NMD is inhibited by compound 2[1].
References
Molecular Weight

602.70

Formula

C₂₅H₁₉Br₂ClN₄O₂

CAS No.

2095677-20-4

SMILES

O=C(C1=CC=C(Br)C=C1)N2CCN(C(C3=C4N(C=C(Br)C=C4)N=C3)=O)C[[email protected]@H]2C5=CC=C(Cl)C=C5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
eIF4A3-IN-2
Cat. No.:
HY-101785
Quantity:

eIF4A3-IN-2

Cat. No.: HY-101785