1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)

eIF4A3-IN-2 

Cat. No.: HY-101785
Handling Instructions

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.

For research use only. We do not sell to patients.

eIF4A3-IN-2 Chemical Structure

eIF4A3-IN-2 Chemical Structure

CAS No. : 2095677-20-4

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.

IC50 & Target

IC50: 110 nM (eIF4A3)[1]

In Vitro

eIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay (NMD) activities[1].

Apoptosis Analysis[1]

Cell Line: HEK293T cells (transfected with the NMD reporter) luciferase assay
Concentration: 0.3, 1, 3, or 10 μM
Incubation Time: 3 or 6 h
Result: eIF4A3-IN-2 induces an approximately 3.2-fold increase in luciferase activity, indicating that NMD is inhibited by compound 2[1].
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6592 mL 8.2960 mL 16.5920 mL
5 mM 0.3318 mL 1.6592 mL 3.3184 mL
10 mM 0.1659 mL 0.8296 mL 1.6592 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

602.70

Formula

C₂₅H₁₉Br₂ClN₄O₂

CAS No.

2095677-20-4

SMILES

O=C(C1=CC=C(Br)C=C1)N2CCN(C(C3=C4N(C=C(Br)C=C4)N=C3)=O)C[[email protected]@H]2C5=CC=C(Cl)C=C5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
eIF4A3-IN-2
Cat. No.:
HY-101785
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eIF4A3-IN-2

Cat. No.: HY-101785