1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)
  3. eIF4A3-IN-2

eIF4A3-IN-2 

Cat. No.: HY-101785 Purity: 99.52% ee.: 99.25%
Handling Instructions

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.

For research use only. We do not sell to patients.

eIF4A3-IN-2 Chemical Structure

eIF4A3-IN-2 Chemical Structure

CAS No. : 2095677-20-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 729 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.

IC50 & Target

IC50: 110 nM (eIF4A3)[1]

In Vitro

eIF4A3-IN-2 (compound 2) binds to the allosteric region in eIF4A3 and inhibits in vitro ATPase, helicase, and cellular nonsense-mediated RNA decay (NMD) activities[1].

Apoptosis Analysis[1]

Cell Line: HEK293T cells (transfected with the NMD reporter) luciferase assay
Concentration: 0.3, 1, 3, or 10 μM
Incubation Time: 3 or 6 h
Result: eIF4A3-IN-2 induces an approximately 3.2-fold increase in luciferase activity, indicating that NMD is inhibited by compound 2[1].
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (165.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6592 mL 8.2960 mL 16.5920 mL
5 mM 0.3318 mL 1.6592 mL 3.3184 mL
10 mM 0.1659 mL 0.8296 mL 1.6592 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (2.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (2.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

602.70

Formula

C₂₅H₁₉Br₂ClN₄O₂

CAS No.

2095677-20-4

SMILES

O=C(C1=CC=C(Br)C=C1)N2CCN(C(C3=C4N(C=C(Br)C=C4)N=C3)=O)C[[email protected]@H]2C5=CC=C(Cl)C=C5

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
eIF4A3-IN-2
Cat. No.:
HY-101785
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eIF4A3-IN-2

Cat. No.: HY-101785