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Cat. No.: HY-139872

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eIF4A3-IN-4

Name: eIF4A3-IN-4
Brand: MedChemExpress
SKU: HY-139872
Price: 478.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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eIF4A3-IN-4 is a novel eIF4A inhibitor with an IC₅₀ value of 8.6 μM.

For research use only. We do not sell to patients.

Purity : 98.92%
CAS No.: 2861994-92-3
Formula: C₂₄H₂₀N₂O₅
Molecular Weight:416.43

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

eIF4A3-IN-4 Chemical Structure

CAS No.: 2861994-92-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

eIF4A3-IN-4 is a novel eIF4A inhibitor with an IC₅₀ value of 8.6 μM.

IC₅₀ & Target

eIF4

Cellular Effect

Cell Line	Type	Value	Description	References
BJAB	EC₅₀	0.463 μM Compound: 28	Cytotoxicity against human BJAB cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo luminescent assay Cytotoxicity against human BJAB cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Glo luminescent assay	[PMID: 34676755]

Chemical Information

CAS No. 2861994-92-3
Appearance Solid
Molecular Weight 416.43
Formula C₂₄H₂₀N₂O₅
Color Yellow to orange
SMILES

OC(C1=C2C(C=CC([N+]([O-])=O)=C2)=NC(C3=CC=C(C4=CC=C(CCCC)C=C4)O3)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zerio CJ, et al. Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action. J Med Chem. 2021 Nov 11;64(21):15727-15746. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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