PRMT5 - protein arginine methyltransferase 5 Gene

Also Known as HSL7; JBP1; SKB1; IBP72; SKB1Hs; HRMT1L5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10419

About PRMT5

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,920,529-22,929,376 (from NCBI)

This gene has 28 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in thyroid (RPKM 21.2), ovary (RPKM 18.5) and 25 other tissues.

Summary

This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

PRMT5 Products (9)

mRNA	Protein	Name
NM_001282955.2	NP_001269884.1	protein arginine N-methyltransferase 5 isoform e
NM_001282956.2	NP_001269885.1	protein arginine N-methyltransferase 5 isoform f
XR_429287.3
NM_001282954.2	NP_001269883.1	protein arginine N-methyltransferase 5 isoform d
XR_001750113.3
NM_006109.5	NP_006100.2	protein arginine N-methyltransferase 5 isoform a
NM_001039619.3	NP_001034708.1	protein arginine N-methyltransferase 5 isoform b
XM_047430881.1	XP_047286837.1	protein arginine N-methyltransferase 5 isoform X1
NM_001282953.2	NP_001269882.1	protein arginine N-methyltransferase 5 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone H4R3 methyltransferase activity	IDA IDA: Inferred from direct assay	18404153	GOA
enables histone H4R3 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	25284789	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	11756452	GOA
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	25284789	GOA
enables methyltransferase activity	IDA IDA: Inferred from direct assay	15369763	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	19011621	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11756452	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	18495660	GOA
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	20421892	GOA
enables protein-arginine omega-N symmetric methyltransferase activity	EXP EXP: Inferred from Experiment	19011621	GOA
enables protein-arginine omega-N symmetric methyltransferase activity	IDA IDA: Inferred from direct assay	22143770	GOA
enables protein-arginine omega-N symmetric methyltransferase activity	IMP IMP: Inferred from mutant phenotype	17709427	GOA
enables ribonucleoprotein complex binding	IPI IPI: Inferred from physical interaction	17709427	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA-templated transcription termination	IMP IMP: Inferred from mutant phenotype	26700805	GOA
involved in Golgi ribbon formation	IMP IMP: Inferred from mutant phenotype	20421892	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	18404153	GOA
involved in endothelial cell activation	IMP IMP: Inferred from mutant phenotype	22269951	GOA
acts upstream of or within peptidyl-arginine N-methylation	IDA IDA: Inferred from direct assay	15369763	GOA
involved in peptidyl-arginine methylation	IMP IMP: Inferred from mutant phenotype	17709427	GOA
involved in positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	26554819	GOA
involved in spliceosomal snRNP assembly	IMP IMP: Inferred from mutant phenotype	17709427	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	20421892	GOA
located in chromatin	IDA IDA: Inferred from direct assay	33376131	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22952863	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18984161	GOA
part of histone methyltransferase complex	IDA IDA: Inferred from direct assay	23048031	GOA
part of methylosome	IDA IDA: Inferred from direct assay	11756452	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21081503	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT5 Protein Structure

PRMT5

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300
400
500
600
637 a.a.

Protein Preferred Names	Protein Names
protein arginine N-methyltransferase 5	72 kDa ICln-binding protein HMT1 hnRNP methyltransferase-like 5 SKB1 homolog histone-arginine N-methyltransferase PRMT5 jak-binding protein 1 shk1 kinase-binding protein 1 homolog

PRMT5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRMT5	O14744	EPHB6	Homo sapiens	O15197-2	Validated Y2H	32296183
Intra	PRMT5	O14744	SRGAP2	Homo sapiens	O75044	Anti Bait CoIP	20810653
Intra	PRMT5	O14744	SRGAP2	Homo sapiens	O75044	Anti Tag CoIP	20810653
Intra	PRMT5	O14744	GAS8	Homo sapiens	O95995	Validated Y2H	32296183
Intra	PRMT5	O14744	WDR77	Homo sapiens	Q9BQA1	Solution Sedimentation	23071334
Intra	PRMT5	O14744	WDR77	Homo sapiens	Q9BQA1	Methyltransferase Ass	20951943
Intra	PRMT5	O14744	WDR77	Homo sapiens	Q9BQA1	Anti Bait CoIP	23892143
Intra	PRMT5	O14744	WDR77	Homo sapiens	Q9BQA1	X-Ray Diffraction	26912361
Intra	PRMT5	O14744	WDR77	Homo sapiens	Q9BQA1	GMS	23071334
Intra	PRMT5	O14744	WDR77	Homo sapiens	Q9BQA1	Anti Tag CoIP	23071334
Intra	PRMT5	O14744	WDR77	Homo sapiens	Q9BQA1	Anti Bait CoIP	11756452
Intra	PRMT5	O14744	WDR77	Homo sapiens	Q9BQA1	Y2H	22365833
Intra	PRMT5	O14744	WDR77	Homo sapiens	Q9BQA1	Pull Down	11756452
Intra	PRMT5	O14744	WDR77	Homo sapiens	Q9BQA1	Anti Tag CoIP	20951943
Intra	PRMT5	O14744	WDR77	Homo sapiens	Q9BQA1	X-Ray Diffraction	23071334
Intra	PRMT5	O14744	NFE4	Homo sapiens	Q86UQ8-1	Pull Down	19234465
Intra	PRMT5	O14744	COPRS	Homo sapiens	Q9NQ92	Density Sedimentation	18404153
Intra	PRMT5	O14744	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
Intra	PRMT5	O14744	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	PRMT5	O14744	CACNB2	Homo sapiens	Q08289	Validated Y2H	32296183
Intra	PRMT5	O14744	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	26700805
Intra	PRMT5	O14744	CDC37	Homo sapiens	Q16543	Validated Y2H	32296183
Intra	PRMT5	O14744	EIF4A3	Homo sapiens	P38919	Validated Y2H	32296183
Intra	PRMT5	O14744	H4C16	Homo sapiens	P62805	Methyltransferase Ass	23071334
Intra	PRMT5	O14744	H4C16	Homo sapiens	P62805	Methyltransferase Ass	20951943
Intra	PRMT5	O14744	H4C16	Homo sapiens	P62805	X-Ray Diffraction	23071334
Intra	PRMT5	O14744	H4C16	Homo sapiens	P62805	X-Ray Diffraction	26912361
Intra	PRMT5	O14744	YWHAZ	Homo sapiens	P63104	CoIP	15324660
Intra	PRMT5	O14744	CLNS1A	Homo sapiens	P54105	Anti Bait CoIP	11756452
Intra	PRMT5	O14744	CLNS1A	Homo sapiens	P54105	Pull Down	11756452
Intra	PRMT5	O14744	E2F1	Homo sapiens	Q01094	Pull Down	22327218
Intra	PRMT5	O14744	E2F1	Homo sapiens	Q01094	Anti Bait CoIP	22327218
Intra	PRMT5	O14744	E2F1	Homo sapiens	Q01094	Anti Tag CoIP	22327218
Intra	PRMT5	O14744	GTPBP2	Homo sapiens	Q9BX10	Anti Tag CoIP	23455924
Intra	PRMT5	O14744	CLNS1A	Homo sapiens	P54105	GMS	18984161
Intra	PRMT5	O14744	RIOK1	Homo sapiens	Q9BRS2	Anti Tag CoIP	25852190
Intra	PRMT5	O14744	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	PRMT5	O14744	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	PRMT5	O14744	HOXA9	Homo sapiens	P31269	Anti Bait CoIP	22269951
Intra	PRMT5	O14744	HOXA9	Homo sapiens	P31269	Anti Tag CoIP	22269951
Intra	PRMT5	O14744	ELOA	Homo sapiens	Q14241	Validated Y2H	32296183
Intra	PRMT5	O14744	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	PRMT5	O14744	RBM23	Homo sapiens	Q86U06	Y2H	22365833
Intra	PRMT5	O14744	RBM23	Homo sapiens	Q86U06	Anti Tag CoIP	23455924
Intra	PRMT5	O14744	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	PRMT5	O14744	DNMT3A	Homo sapiens	Q9Y6K1	Anti Tag CoIP	19234465
Intra	PRMT5	O14744	DNMT3A	Homo sapiens	Q9Y6K1	Anti Bait CoIP	19234465

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRMT5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77152	PRMT5 Protein, Human (HEK293, His-Flag)	NP_006100.2 (A2-L637)	≥ 90%, as determined by reducing SDS-PAGE.

PRMT5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82108	PRMT5 Antibody (YA1853)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Sarcomatoid Transitional Cell Carcinoma	Transitional Cell Carcinoma, Sarcomatoid Transitional Spindle Cell Carcinoma Transitional Cell Carcinoma, Spindle Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101563	GSK3326595	Inhibitor	99.83%	Phase 2
HY-101564	Onametostat	Inhibitor	99.79%	Phase 1
HY-131493	PF-06939999	Inhibitor	99.84%	Phase 1

Pre-clinical Phase

Bioactive Molecules (56)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139611	Navlimetostat	Inhibitor	99.28%	Unkown
HY-12727	EPZ015666	Inhibitor	99.86%	Unkown
HY-100235	GSK591	Inhibitor	99.91%	Unkown
HY-107777	LLY-283	Inhibitor	98.93%	Unkown
HY-148419	Ralometostat	Inhibitor	99.90%	Unkown
HY-141877	MS4322	Degrader	99.14%	Unkown
HY-124131	DS-437	Inhibitor	99.22%	Unkown
HY-100025A	HLCL-61 hydrochloride	Inhibitor	99.87%	Unkown
HY-132309	BRD0639	Inhibitor	98.04%	Unkown
HY-138684	MRTX9768	Inhibitor	99.60%	Unkown
HY-139611C	Navlimetostat hydrochloride	Inhibitor	99.61%	Unkown
HY-148674	AM-9747	Inhibitor	99.76%	Unkown
HY-109963	PR5-LL-CM01	Inhibitor	98.37%	Unkown
HY-Q36691	PRMT5-IN-30	Inhibitor	99.35%	Unkown
HY-139611B	(S)-Navlimetostat	Inhibitor	98.15%	Unkown
HY-141877B	MS4322 (isomer)		99.87%	Unkown
HY-120137	CMP-5	Inhibitor	99.61%	Unkown
HY-158143	AZD3470	Inhibitor	99.74%	Unkown
HY-128579	DW14800	Inhibitor	99.12%	Unkown
HY-126256A	PRMT5-IN-1 hydrochloride	Inhibitor	99.51%	Unkown
HY-W072962	WX2-43	Inhibitor	98.74%	Unkown
HY-111213	PRMT5-IN-20	Inhibitor	99.20%	Unkown
HY-126256	PRMT5-IN-1	Inhibitor	/	Unkown
HY-138684A	MRTX9768 hydrochloride	Inhibitor	99.88%	Unkown
HY-182820	YZ-836P		/	Unkown
HY-134883	PRMT5-IN-4	Inhibitor	99.0%	Unkown
HY-141876	PRT543	Inhibitor	/	Unkown
HY-182892	MC4491	Inhibitor	/	Unkown
HY-169708	PRMT5-IN-49	Inhibitor	/	Unkown
HY-173092	PRMT5 ligand 1	Ligand	/	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-163593	PRMT5-IN-44	Inhibitor	/	Unkown
HY-176534	PRMT5-IN-52	Inhibitor	/	Unkown
HY-111213A	PRMT5-IN-20 hydrochloride	Ligand	/	Unkown
HY-178028	PRMT5-IN-53	Inhibitor	/	Unkown
HY-150081	PRMT5-IN-21	Inhibitor	/	Unkown
HY-175821	PRMT1-IN-3	Inhibitor	/	Unkown
HY-168842	PRMT5-IN-47	Inhibitor	/	Unkown
HY-163587	PRMT5-IN-39-d3	Inhibitor	/	Unkown
HY-163799	PRMT5-MTA-IN-1	Inhibitor	/	Unkown
HY-P3822	PRMT5-IN-23	Inhibitor	/	Unkown
HY-180356	PRMT5-IN-54	Inhibitor	/	Unkown
HY-132937	PRMT5-IN-9	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-176702	PRMT5-MTA-IN-5	Inhibitor	/	Unkown
HY-153421	PRMT5-IN-28	Inhibitor	/	Unkown
HY-176701	PRMT5-MTA-IN-4	Inhibitor	/	Unkown
HY-163592	PRMT5-IN-43	Inhibitor	/	Unkown
HY-181522	PRMT5 ligand 3	Ligand	/	Unkown
HY-183951	TNG456	Inhibitor	/	Unkown
HY-184434	PRMT5-IN-57	Inhibitor	/	Unkown
HY-168263	PRMT5-IN-45	Inhibitor	/	Unkown
HY-149005	PRMT5-IN-19	Inhibitor	/	Unkown
HY-163591	PRMT5-IN-36-d3	Inhibitor	/	Unkown
HY-181521	RAPRMT5	Degrader	/	Unkown
HY-162230	PRMT5-IN-33	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PRMT5	VGNC	VGNC:76245
Canis familiaris	PRMT5	VGNC	VGNC:44998
Bos taurus	PRMT5	VGNC	VGNC:33350
Rattus norvegicus	PRMT5	RGD	RGD:1309053
Mus musculus	PRMT5	MGD	MGI:1351645
Felis catus	PRMT5	VGNC	VGNC:64360
Others	PRMT5	NCBI