PRMT5 - protein arginine methyltransferase 5 Gene

Homo sapiens

Also known as HSL7; JBP1; SKB1; IBP72; SKB1Hs; HRMT1L5

Gene ID: 10419 | Gene type: protein coding

About PRMT5

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,920,529-22,929,376 (from NCBI)

This gene has 28 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in thyroid (RPKM 21.2), ovary (RPKM 18.5) and 25 other tissues.

Summary

This gene encodes an Enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

PRMT5 Products(9)

mRNA	Protein	Name
NM_001282955.2	NP_001269884.1	protein arginine N-methyltransferase 5 isoform e
NM_001282956.2	NP_001269885.1	protein arginine N-methyltransferase 5 isoform f
XR_429287.3
NM_001282954.2	NP_001269883.1	protein arginine N-methyltransferase 5 isoform d
XR_001750113.3
NM_006109.5	NP_006100.2	protein arginine N-methyltransferase 5 isoform a
NM_001039619.3	NP_001034708.1	protein arginine N-methyltransferase 5 isoform b
XM_047430881.1	XP_047286837.1	protein arginine N-methyltransferase 5 isoform X1
NM_001282953.2	NP_001269882.1	protein arginine N-methyltransferase 5 isoform c

PRMT5 Protein Structure

PRMT5

0
100
200
300
400
500
600
637 a.a.

Protein Preferred Names

Protein Names

protein arginine N-methyltransferase 5

72 kDa ICln-binding protein	HMT1 hnRNP methyltransferase-like 5
SKB1 homolog	histone-arginine N-methyltransferase PRMT5
jak-binding protein 1	shk1 kinase-binding protein 1 homolog

Recombinant PRMT5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77152	PRMT5 Protein, Human (HEK293, His-Flag)	O14744 (A2-L637)	≥95%

Related Diseases

Diseases

Alias

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Sarcomatoid Transitional Cell Carcinoma

Transitional Cell Carcinoma, Sarcomatoid	Transitional Spindle Cell Carcinoma
Transitional Cell Carcinoma, Spindle Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101563	GSK3326595	Inhibitor	99.97%	Phase 2
HY-139611	MRTX-1719	Inhibitor	99.40%	Phase 2
HY-148419	TNG908	Inhibitor	98.89%	Phase 2
HY-101564	Onametostat	Inhibitor	99.79%	Phase 1
HY-131493	PF-06939999	Inhibitor	99.69%	Phase 1

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100235	GSK591	Inhibitor	99.87%	Unkown
HY-107777	LLY-283	Inhibitor	99.22%	Unkown
HY-138684	MRTX9768	Inhibitor	99.60%	Unkown
HY-124131	DS-437	Inhibitor	98.00%	Unkown
HY-132309	BRD0639	Inhibitor	99.17%	Unkown
HY-148674	PRMT5-IN-25	Inhibitor	99.94%	Unkown
HY-100025A	HLCL-61 hydrochloride	Inhibitor	99.95%	Unkown
HY-139611C	MRTX-1719 hydrochloride	Inhibitor	99.22%	Unkown
HY-128579	DW14800	Inhibitor	99.63%	Unkown
HY-Q36691	PRMT5-IN-30	Inhibitor	≥95%	Unkown
HY-126256	PRMT5-IN-1	Inhibitor	/	Unkown
HY-134883	PRMT5-IN-4	Inhibitor	≥99.0%	Unkown
HY-141876	PRMT5-IN-14	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-150081	PRMT5-IN-21	Inhibitor	/	Unkown
HY-149005	PRMT5-IN-19	Inhibitor	/	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-153421	PRMT5-IN-28	Inhibitor	/	Unkown
HY-139611B	(S)-MRTX-1719	Inhibitor	97.07%	Unkown
HY-162230	PRMT5-IN-33	Inhibitor	/	Unkown
HY-P3822	PRMT5-IN-23	Inhibitor	/	Unkown
HY-132937	PRMT5-IN-9	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PRMT5	VGNC	VGNC:76245
Canis familiaris	PRMT5	VGNC	VGNC:44998
Bos taurus	PRMT5	VGNC	VGNC:33350
Rattus norvegicus	PRMT5	RGD	RGD:1309053
Mus musculus	PRMT5	MGD	MGI:1351645
Felis catus	PRMT5	VGNC	VGNC:64360

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