GSK591 (Synonyms: EPZ015866; GSK3203591)

Name: GSK591
Brand: MedChemExpress
SKU: HY-100235
Rating: 5.0 (13 reviews)

Cat. No.: HY-100235 Purity: 99.91%: Data Sheet
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GSK591 (EPZ015866), a chemical probe, is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC₅₀ of 4 nM.

For research use only. We do not sell to patients.

CAS No. : 1616391-87-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of GSK591:

GSK591 hydrochloride Get quote
GSK591 (Standard) Get quote

13 Publications Citing Use of MCE GSK591

Cell Proliferation/Viability Assay

In Vivo Efficacy Study

: GSK591 purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2022 Nov 16;422(1):113413. [Abstract]; GSK591 (PRMT5i; 200-1000 nM) in combination with EPZ020411 (PRMT6i; 200-1000 nM) exhibits a synergistic anti-proliferative effect on HCT116 and SW620 cells.

: GSK591 purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Jan 27;11(8):3742-3759. [Abstract]; The compound dose-response matrix for proliferation inhibition of HCT116 and SW480 cells treated with PRMT5i (GSK591) (10-100 μM; 7 days) and EZH2i (GSK126). Color gradation indicates percentage viability at the indicated dose combination. Combination index (CI) plots for 100 nM PRMT5i (GSK591) (top) or EZH2i (GSK126) (bottom) with graded doses of EZH2i (GSK126) or PRMT5i (GSK591) in HCT116 and SW480 cells.

: GSK591 purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Jan 27;11(8):3742-3759. [Abstract]; Immunoblots of PRMT5, EZH2 and CDKN2B (p15INK4b) protein levels in HCT116 and SW480 cells following treatment with PRMT5i (GSK591; 100 nM), EZH2i (GSK126; 100 nM), or PRMT5i (GSK591; 100 nM) + EZH2i (GSK126; 100 nM). GAPDH was used as a loading control. Western blot analysis clearly showed that the selected combination of PRMT5i (GSK591) and EZH2i (GSK126) robustly activated the protein expression of CDKN2B.

: GSK591 purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Jan 27;11(8):3742-3759. [Abstract]; Representative images of xenograft tumors excised from mice. Control, PRMT5i (GSK591) (100 mg/kg; i.p.; every other day for a month), EZH2i (GSK126) (100 mg/kg; i.p.; every other day for a month), or PRMT5i (GSK591) + EZH2i (GSK126)-treated HCT116 cells were subcutaneously injected into the flank of nude mice.

: GSK591 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]; ChIP assay analysis of the enrichment of H3R2me1 and H3R2me2s on the promoter of SLC7A11 in the indicated cells treated with PRMT5 inhibitor GSK591 (5 μM, 1 h). ChIP-qPCR of Histone 3 served as the control. The results showed that inhibiting PRMT5 activity using the PRMT5 inhibitor GSK591 significantly reduced the levels of H3R2me1 and H3R2me2s on the SLC7A11 promoter in CPT-treated cells.

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•Related Small Molecules:

•Related Proteins:

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
Purity & Documentation
References
Customer Review

Description

GSK591 (EPZ015866), a chemical probe, is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC₅₀ of 4 nM^[1].

IC₅₀ & Target

PRMT5

Cellular Effect

Cell Line	Type	Value	Description	References
5637	GI₅₀	0.143 μM Compound: GSK3203591	Antiproliferative activity against human 5637 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human 5637 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
5637	GI₅₀	285 nM Compound: GSK3203591	Antiproliferative activity against human 5637 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human 5637 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
639-V	GI₅₀	342 nM Compound: GSK3203591	Antiproliferative activity against human 639-V cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human 639-V cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
647-V	GI₅₀	62 nM Compound: GSK3203591	Antiproliferative activity against human 647-V cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human 647-V cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
769-P	GI₅₀	203 nM Compound: GSK3203591	Antiproliferative activity against human 769-P cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human 769-P cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
786-0	GI₅₀	20.3 nM Compound: GSK3203591	Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
A 172	GI₅₀	0.59 μM Compound: GSK3203591	Antiproliferative activity against human A-172 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human A-172 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
A 172	GI₅₀	29.6 nM Compound: GSK3203591	Antiproliferative activity against human A-172 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human A-172 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
A-375	GI₅₀	79.6 nM Compound: GSK3203591	Antiproliferative activity against human A-375 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human A-375 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
A-427	GI₅₀	130 nM Compound: GSK3203591	Antiproliferative activity against human A-427 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human A-427 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
A-431	GI₅₀	549 nM Compound: GSK3203591	Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
A101D	GI₅₀	190 nM Compound: GSK3203591	Antiproliferative activity against human A101D cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human A101D cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
A204	GI₅₀	223 nM Compound: GSK3203591	Antiproliferative activity against human A204 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human A204 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
A498	GI₅₀	50.7 nM Compound: GSK3203591	Antiproliferative activity against human A498 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human A498 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
A549	GI₅₀	80.9 nM Compound: GSK3203591	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
A673	GI₅₀	119 nM Compound: GSK3203591	Antiproliferative activity against human A673 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human A673 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
ACHN	GI₅₀	38.6 nM Compound: GSK3203591	Antiproliferative activity against human ACHN cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human ACHN cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
AGS	GI₅₀	2030 nM Compound: GSK3203591	Antiproliferative activity against human AGS cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human AGS cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
AN3-CA	GI₅₀	254 nM Compound: GSK3203591	Antiproliferative activity against human AN3-CA cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human AN3-CA cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
ARH-77	GI₅₀	44.4 nM Compound: GSK3203591	Antiproliferative activity against human ARH-77 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human ARH-77 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
ASPC1	GI₅₀	302 nM Compound: GSK3203591	Antiproliferative activity against human ASPC1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human ASPC1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
AU565	GI₅₀	14.6 nM Compound: GSK3203591	Antiproliferative activity against human AU565 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human AU565 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
BE(2)-C	GI₅₀	803 nM Compound: GSK3203591	Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
BFTC-905	GI₅₀	259 nM Compound: GSK3203591	Antiproliferative activity against human BFTC-905 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human BFTC-905 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
BHT-101	GI₅₀	214 nM Compound: GSK3203591	Antiproliferative activity against human BHT-101 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human BHT-101 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
BJAB	GI₅₀	3.1 μM Compound: GSK3203591	Antiproliferative activity against human BJAB cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human BJAB cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
BPH-1	GI₅₀	718 nM Compound: GSK3203591	Antiproliferative activity against human BPH-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human BPH-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
BT-20	GI₅₀	2280 nM Compound: GSK3203591	Antiproliferative activity against human BT-20 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human BT-20 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
BT-474	GI₅₀	172 nM Compound: GSK3203591	Antiproliferative activity against human BT-474 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human BT-474 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
BT-549	GI₅₀	59.4 nM Compound: GSK3203591	Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
BV-173	GI₅₀	10.6 nM Compound: GSK3203591	Antiproliferative activity against human BV-173 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human BV-173 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
BXPC-3	GI₅₀	160 nM Compound: GSK3203591	Antiproliferative activity against human BXPC-3 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human BXPC-3 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
BeWo	GI₅₀	1090 nM Compound: GSK3203591	Antiproliferative activity against human BeWo cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human BeWo cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
C-33-A	GI₅₀	228 nM Compound: GSK3203591	Antiproliferative activity against human C-33-A cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human C-33-A cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
C-4-II	GI₅₀	266 nM Compound: GSK3203591	Antiproliferative activity against human C-4-II cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human C-4-II cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
C32	GI₅₀	14.1 nM Compound: GSK3203591	Antiproliferative activity against human C32 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human C32 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CAKI-1	GI₅₀	68.8 nM Compound: GSK3203591	Antiproliferative activity against human CAKI-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CAKI-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CAKI-2	GI₅₀	114 nM Compound: GSK3203591	Antiproliferative activity against human CAKI-2 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CAKI-2 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CAL-27	GI₅₀	103 nM Compound: GSK3203591	Antiproliferative activity against human CAL-27 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CAL-27 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CAL-62	GI₅₀	253 nM Compound: GSK3203591	Antiproliferative activity against human CAL-62 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CAL-62 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CAMA-1	GI₅₀	78.9 nM Compound: GSK3203591	Antiproliferative activity against human CAMA-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CAMA-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CAPAN-1	GI₅₀	370 nM Compound: GSK3203591	Antiproliferative activity against human CAPAN-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CAPAN-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CCF-STTG1	GI₅₀	115 nM Compound: GSK3203591	Antiproliferative activity against human CCF-STTG1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CCF-STTG1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CCRF-CEM	GI₅₀	3140 nM Compound: GSK3203591	Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CFPAC-1	GI₅₀	52.3 nM Compound: GSK3203591	Antiproliferative activity against human CFPAC-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CFPAC-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CGTH-W-1	GI₅₀	82.2 nM Compound: GSK3203591	Antiproliferative activity against human CGTH-W-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CGTH-W-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CHL-1	GI₅₀	247 nM Compound: GSK3203591	Antiproliferative activity against human CHL-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CHL-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CHP-212	GI₅₀	24 nM Compound: GSK3203591	Antiproliferative activity against human CHP-212 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CHP-212 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
COLO 201	GI₅₀	49.6 nM Compound: GSK3203591	Antiproliferative activity against human COLO201 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human COLO201 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
COLO 205	GI₅₀	10000 nM Compound: GSK3203591	Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
COLO 320	GI₅₀	80.3 nM Compound: GSK3203591	Antiproliferative activity against human COLO 320 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human COLO 320 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
COLO 320DM	GI₅₀	82.5 nM Compound: GSK3203591	Antiproliferative activity against human Colo 320DM cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Colo 320DM cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
COLO-829	GI₅₀	54.4 nM Compound: GSK3203591	Antiproliferative activity against human COLO-829 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human COLO-829 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
COR-L105	GI₅₀	314 nM Compound: GSK3203591	Antiproliferative activity against human COR-L105 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human COR-L105 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
COR-L23	GI₅₀	147 nM Compound: GSK3203591	Antiproliferative activity against human COR-L23 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human COR-L23 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CRO-AP2	GI₅₀	250 nM Compound: GSK3203591	Antiproliferative activity against human CRO-AP2 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human CRO-AP2 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
CWR22R	GI₅₀	2480 nM Compound: GSK3203591	Antiproliferative activity against human 22Rv1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human 22Rv1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Calu-1	GI₅₀	3050 nM Compound: GSK3203591	Antiproliferative activity against human Calu-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Calu-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Calu-6	GI₅₀	206 nM Compound: GSK3203591	Antiproliferative activity against human Calu-6 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Calu-6 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Capan-2	GI₅₀	69.7 nM Compound: GSK3203591	Antiproliferative activity against human Capan-2 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Capan-2 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
ChaGo-K-1	GI₅₀	1190 nM Compound: GSK3203591	Antiproliferative activity against human ChaGo-K-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human ChaGo-K-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
D283 Med	GI₅₀	23.5 nM Compound: GSK3203591	Antiproliferative activity against human D283 Med cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human D283 Med cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
DB	GI₅₀	2.51 nM Compound: GSK3203591	Antiproliferative activity against human DB cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human DB cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
DBTRG-05MG	GI₅₀	156 nM Compound: GSK3203591	Antiproliferative activity against human DBTRG-05MG cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human DBTRG-05MG cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
DK-MG	GI₅₀	89.5 nM Compound: GSK3203591	Antiproliferative activity against human DK-MG cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human DK-MG cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
DLD-1	GI₅₀	134 nM Compound: GSK3203591	Antiproliferative activity against human DLD-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human DLD-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
DMS-114	GI₅₀	1010 nM Compound: GSK3203591	Antiproliferative activity against human DMS-114 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human DMS-114 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
DMS-273	GI₅₀	298 nM Compound: GSK3203591	Antiproliferative activity against human DMS-273 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human DMS-273 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
DMS-53	GI₅₀	106 nM Compound: GSK3203591	Antiproliferative activity against human DMS-53 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human DMS-53 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
DOHH-2	GI₅₀	0.116 μM Compound: GSK3203591	Antiproliferative activity against human DOHH-2 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human DOHH-2 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
DOHH-2	GI₅₀	157 nM Compound: GSK3203591	Antiproliferative activity against human DOHH-2 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human DOHH-2 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
DU-145	GI₅₀	151 nM Compound: GSK3203591	Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Daoy	GI₅₀	270 nM Compound: GSK3203591	Antiproliferative activity against human Daoy cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Daoy cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Daudi	GI₅₀	142 nM Compound: GSK3203591	Antiproliferative activity against human Daudi cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Daudi cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Detroit 562	GI₅₀	104 nM Compound: GSK3203591	Antiproliferative activity against human Detroit 562 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Detroit 562 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
DoTc2-4510	GI₅₀	95.8 nM Compound: GSK3203591	Antiproliferative activity against human DoTc2-4510 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human DoTc2-4510 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
EB-3	GI₅₀	299 nM Compound: GSK3203591	Antiproliferative activity against human EB-3 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human EB-3 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
EFM-19	GI₅₀	69.5 nM Compound: GSK3203591	Antiproliferative activity against human EFM-19 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human EFM-19 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
EM-2	GI₅₀	94 nM Compound: GSK3203591	Antiproliferative activity against human EM-2 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human EM-2 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
ES-2	GI₅₀	106 nM Compound: GSK3203591	Antiproliferative activity against human ES2 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human ES2 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
FaDu	GI₅₀	15.4 nM Compound: GSK3203591	Antiproliferative activity against human FaDu cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human FaDu cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
G-401	GI₅₀	38.4 nM Compound: GSK3203591	Antiproliferative activity against human G-401 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human G-401 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
G-402	GI₅₀	99.7 nM Compound: GSK3203591	Antiproliferative activity against human G-402 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human G-402 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
H4	GI₅₀	151 nM Compound: GSK3203591	Antiproliferative activity against human H4 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human H4 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HCC1143	GI₅₀	0.509 μM Compound: GSK3203591	Antiproliferative activity against human HCC1143 cells assessed as cell growth inhibition viability incubated for 6 days by celltiter-glo assay Antiproliferative activity against human HCC1143 cells assessed as cell growth inhibition viability incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
HCC1806	GI₅₀	0.261 μM Compound: GSK3203591	Antiproliferative activity against human HCC1806 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human HCC1806 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
HCC70	GI₅₀	0.522 μM Compound: GSK3203591	Antiproliferative activity against human HCC70 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human HCC70 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
HCT-116	GI₅₀	166 nM Compound: GSK3203591	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HCT-15	GI₅₀	68.4 nM Compound: GSK3203591	Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HCT-8	GI₅₀	430 nM Compound: GSK3203591	Antiproliferative activity against human HCT-8 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HCT-8 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HEC-1-A	GI₅₀	2440 nM Compound: GSK3203591	Antiproliferative activity against human HEC-1-A cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HEC-1-A cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HEL 92.1.7	GI₅₀	9.02 nM Compound: GSK3203591	Antiproliferative activity against human HEL 92.1.7 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HEL 92.1.7 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HLE	GI₅₀	174 nM Compound: GSK3203591	Antiproliferative activity against human HLE cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HLE cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HOS	GI₅₀	223 nM Compound: GSK3203591	Antiproliferative activity against human HOS cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HOS cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HPAF-II	GI₅₀	154 nM Compound: GSK3203591	Antiproliferative activity against human HPAF-II cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HPAF-II cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HT	GI₅₀	206 nM Compound: GSK3203591	Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HT-1080	GI₅₀	53.5 nM Compound: GSK3203591	Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HT-1376	GI₅₀	13.13 μM Compound: GSK3203591	Antiproliferative activity against human HT-1376 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human HT-1376 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
HT-1376	GI₅₀	297 nM Compound: GSK3203591	Antiproliferative activity against human HT-1376 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HT-1376 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HT-29	GI₅₀	95.2 nM Compound: GSK3203591	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HT-3	GI₅₀	10000 nM Compound: GSK3203591	Antiproliferative activity against human HT-3 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HT-3 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HT1197	GI₅₀	98.9 nM Compound: GSK3203591	Antiproliferative activity against human HT1197 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HT1197 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HUH-6-clone5	GI₅₀	361 nM Compound: GSK3203591	Antiproliferative activity against human HUH-6-clone5 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HUH-6-clone5 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HeLa	GI₅₀	230 nM Compound: GSK3203591	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HepG2	GI₅₀	214 nM Compound: GSK3203591	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Hs 294T	GI₅₀	12.3 nM Compound: GSK3203591	Antiproliferative activity against human Hs294T cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Hs294T cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Hs 695T	GI₅₀	602 nM Compound: GSK3203591	Antiproliferative activity against human Hs 695T cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Hs 695T cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Hs 766	GI₅₀	1120 nM Compound: GSK3203591	Antiproliferative activity against human Hs766T cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Hs766T cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Hs-578T	GI₅₀	947 nM Compound: GSK3203591	Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Hs746T	GI₅₀	171 nM Compound: GSK3203591	Antiproliferative activity against human Hs746T cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Hs746T cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HuCCT-1	GI₅₀	225 nM Compound: GSK3203591	Antiproliferative activity against human HuCCT-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HuCCT-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
HuP-T4	GI₅₀	84.9 nM Compound: GSK3203591	Antiproliferative activity against human HuP-T4 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human HuP-T4 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
J-RT3-T3-5	GI₅₀	43.2 nM Compound: GSK3203591	Antiproliferative activity against human J-RT3-T3-5 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human J-RT3-T3-5 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
J82	GI₅₀	20.947 μM Compound: GSK3203591	Antiproliferative activity against human J82 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human J82 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
J82	GI₅₀	83.1 nM Compound: GSK3203591	Antiproliferative activity against human J82 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human J82 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
JAR	GI₅₀	485 nM Compound: GSK3203591	Antiproliferative activity against human JAR cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human JAR cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
JEG-3	GI₅₀	216 nM Compound: GSK3203591	Antiproliferative activity against human JEG-3 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human JEG-3 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
JM1	GI₅₀	0.076 μM Compound: GSK3203591	Antiproliferative activity against human JM1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human JM1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
JVM-2	GI₅₀	0.172 μM Compound: GSK3203591	Antiproliferative activity against human JVM-2 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human JVM-2 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
JeKo-1	GI₅₀	6.191 μM Compound: GSK3203591	Antiproliferative activity against human JeKo-1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human JeKo-1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
Jurkat	GI₅₀	130 nM Compound: GSK3203591	Antiproliferative activity against human Jurkat cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Jurkat cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
K562	GI₅₀	146 nM Compound: GSK3203591	Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
KLE	GI₅₀	10000 nM Compound: GSK3203591	Antiproliferative activity against human KLE cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human KLE cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
KMS-11	GI₅₀	0.047 μM Compound: GSK3203591	Antiproliferative activity against human KMS-11 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human KMS-11 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
L-428	GI₅₀	330 nM Compound: GSK3203591	Antiproliferative activity against human L-428 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human L-428 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
LN-229	GI₅₀	1.15 μM Compound: GSK3203591	Antiproliferative activity against human LN-229 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human LN-229 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
LNCaP	GI₅₀	2930 nM Compound: GSK3203591	Antiproliferative activity against human LNCaP cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human LNCaP cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
LP-1	GI₅₀	0.975 μM Compound: GSK3203591	Antiproliferative activity against human LP-1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human LP-1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
LS-1034	GI₅₀	172 nM Compound: GSK3203591	Antiproliferative activity against human LS1034 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human LS1034 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
LS174T	GI₅₀	170 nM Compound: GSK3203591	Antiproliferative activity against human LS174T cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human LS174T cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MC-IXC	GI₅₀	615 nM Compound: GSK3203591	Antiproliferative activity against human MC-IXC cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MC-IXC cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MCF7	GI₅₀	0.215 μM Compound: GSK3203591	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
MCF7	GI₅₀	10.9 nM Compound: GSK3203591	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MDA-MB-231	GI₅₀	2.928 μM Compound: GSK3203591	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
MDA-MB-231	GI₅₀	56.7 nM Compound: GSK3203591	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MDA-MB-436	GI₅₀	49.7 nM Compound: GSK3203591	Antiproliferative activity against human MDA-MB-436 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MDA-MB-436 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MDA-MB-453	GI₅₀	0.343 μM Compound: GSK3203591	Antiproliferative activity against human MDA-MB-453 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human MDA-MB-453 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
MDA-MB-453	GI₅₀	64.5 nM Compound: GSK3203591	Antiproliferative activity against human MDA-MB-453 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MDA-MB-453 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MDA-MB-468	GI₅₀	0.585 μM Compound: GSK3203591	Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
MDA-MB-468	GI₅₀	4.83 nM Compound: GSK3203591	Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MEG-01	GI₅₀	10000 nM Compound: GSK3203591	Antiproliferative activity against human MEG-01 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MEG-01 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MES-SA	GI₅₀	72 nM Compound: GSK3203591	Antiproliferative activity against human MES-SA cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MES-SA cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MG-63	GI₅₀	96 nM Compound: GSK3203591	Antiproliferative activity against human MG-63 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MG-63 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MHH-PREB-1	GI₅₀	10000 nM Compound: GSK3203591	Antiproliferative activity against human MHH-PREB-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MHH-PREB-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MIA PaCa-2	GI₅₀	158 nM Compound: GSK3203591	Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MOLT-16	GI₅₀	54.2 nM Compound: GSK3203591	Antiproliferative activity against human MOLT-16 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MOLT-16 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MOLT-3	GI₅₀	217 nM Compound: GSK3203591	Antiproliferative activity against human MOLT-3 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MOLT-3 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MV4-11	GI₅₀	65.8 nM Compound: GSK3203591	Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
MX1	GI₅₀	294 nM Compound: GSK3203591	Antiproliferative activity against human MX1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MX1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Malme-3M	GI₅₀	265 nM Compound: GSK3203591	Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Maver1	GI₅₀	0.133 μM Compound: GSK3203591	Antiproliferative activity against human MAVER-1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human MAVER-1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
MeWo	GI₅₀	249 nM Compound: GSK3203591	Antiproliferative activity against human MeWo cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human MeWo cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NALM-6	GI₅₀	110 nM Compound: GSK3203591	Antiproliferative activity against human NALM-6 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NALM-6 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NCI-H292	GI₅₀	166 nM Compound: GSK3203591	Antiproliferative activity against human NCI-H292 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NCI-H292 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NCI-H295R	GI₅₀	10000 nM Compound: GSK3203591	Antiproliferative activity against human NCI-H295R cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NCI-H295R cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NCI-H441	GI₅₀	556 nM Compound: GSK3203591	Antiproliferative activity against human NCI-H441 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NCI-H441 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NCI-H446	GI₅₀	570 nM Compound: GSK3203591	Antiproliferative activity against human NCI-H446 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NCI-H446 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NCI-H460	GI₅₀	224 nM Compound: GSK3203591	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NCI-H508	GI₅₀	307 nM Compound: GSK3203591	Antiproliferative activity against human NCI-H508 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NCI-H508 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NCI-H520	GI₅₀	15.6 nM Compound: GSK3203591	Antiproliferative activity against human NCI-H520 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NCI-H520 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NCI-H526	GI₅₀	0.138 μM Compound: GSK3203591	Antiproliferative activity against human NCI-H526 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human NCI-H526 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
NCI-H596	GI₅₀	188 nM Compound: GSK3203591	Antiproliferative activity against human NCI-H596 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NCI-H596 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NCI-H661	GI₅₀	152 nM Compound: GSK3203591	Antiproliferative activity against human NCI-H661 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NCI-H661 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NCI-H69	GI₅₀	144 nM Compound: GSK3203591	Antiproliferative activity against human NCI-H69 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NCI-H69 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NCI-H747	GI₅₀	2580 nM Compound: GSK3203591	Antiproliferative activity against human NCI-H747 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human NCI-H747 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
NU-DHL-1	GI₅₀	0.101 μM Compound: GSK3203591	Antiproliferative activity against human NU-DHL-1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human NU-DHL-1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
OE19	GI₅₀	98 nM Compound: GSK3203591	Antiproliferative activity against human OE19 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human OE19 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
OE33	GI₅₀	231 nM Compound: GSK3203591	Antiproliferative activity against human OE33 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human OE33 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
OVCAR-3	GI₅₀	51.4 nM Compound: GSK3203591	Antiproliferative activity against human OVCAR-3 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human OVCAR-3 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
PANC-1	GI₅₀	165 nM Compound: GSK3203591	Antiproliferative activity against human PANC-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human PANC-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
PC-3	GI₅₀	873 nM Compound: GSK3203591	Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Pfeiffer	GI₅₀	0.352 μM Compound: GSK3203591	Antiproliferative activity against human Pfeiffer cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human Pfeiffer cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
RCK8	GI₅₀	2.11 μM Compound: GSK3203591	Antiproliferative activity against human RCK8 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human RCK8 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
RD	GI₅₀	639 nM Compound: GSK3203591	Antiproliferative activity against human RD cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human RD cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
RKO	GI₅₀	772 nM Compound: GSK3203591	Antiproliferative activity against human RKO cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human RKO cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
RL	GI₅₀	1.434 μM Compound: GSK3203591	Antiproliferative activity against human RL cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human RL cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
RL95-2	GI₅₀	218 nM Compound: GSK3203591	Antiproliferative activity against human RL95-2 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human RL95-2 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
RPMI-6666	GI₅₀	748 nM Compound: GSK3203591	Antiproliferative activity against human RPMI-6666 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human RPMI-6666 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
RPMI-7951	GI₅₀	44.2 nM Compound: GSK3203591	Antiproliferative activity against human RPMI-7951 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human RPMI-7951 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
RPMI-8226	GI₅₀	58.4 nM Compound: GSK3203591	Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Raji	GI₅₀	24.5 nM Compound: GSK3203591	Antiproliferative activity against human Raji cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Raji cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Ramos	GI₅₀	546 nM Compound: GSK3203591	Antiproliferative activity against human Ramos cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Ramos cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Rec1	GI₅₀	1.994 μM Compound: GSK3203591	Antiproliferative activity against human REC1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human REC1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SAOS-2	GI₅₀	48.2 nM Compound: GSK3203591	Antiproliferative activity against human SAOS-2 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SAOS-2 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SCC-25	GI₅₀	273 nM Compound: GSK3203591	Antiproliferative activity against human SCC-25 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SCC-25 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SCC-4	GI₅₀	286 nM Compound: GSK3203591	Antiproliferative activity against human SCC-4 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SCC-4 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SCC-9	GI₅₀	747 nM Compound: GSK3203591	Antiproliferative activity against human SCC-9 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SCC-9 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SCaBER	GI₅₀	0.255 μM Compound: GSK3203591	Antiproliferative activity against human SCaBER cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SCaBER cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SCaBER	GI₅₀	123 nM Compound: GSK3203591	Antiproliferative activity against human SCaBER cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SCaBER cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SF-295	GI₅₀	9.843 μM Compound: GSK3203591	Antiproliferative activity against human SF-295 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SF-295 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SF-539	GI₅₀	0.075 μM Compound: GSK3203591	Antiproliferative activity against human SF-539 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SF-539 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SH-4	GI₅₀	75.2 nM Compound: GSK3203591	Antiproliferative activity against human SH-4 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SH-4 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SHP77	GI₅₀	152 nM Compound: GSK3203591	Antiproliferative activity against human SHP77 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SHP77 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SJRH30	GI₅₀	472 nM Compound: GSK3203591	Antiproliferative activity against human SJRH30 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SJRH30 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SJSA-1	GI₅₀	773 nM Compound: GSK3203591	Antiproliferative activity against human SJSA-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SJSA-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-BR-3	GI₅₀	0.131 μM Compound: GSK3203591	Antiproliferative activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SK-BR-3	GI₅₀	76.4 nM Compound: GSK3203591	Antiproliferative activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-LMS-1	GI₅₀	113 nM Compound: GSK3203591	Antiproliferative activity against human SK-LMS-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-LMS-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-MEL-1	GI₅₀	38.7 nM Compound: GSK3203591	Antiproliferative activity against human SK-MEL-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-MEL-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-MEL-28	GI₅₀	239 nM Compound: GSK3203591	Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-MEL3	GI₅₀	181 nM Compound: GSK3203591	Antiproliferative activity against human SK-MEL3 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-MEL3 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-MES-1	GI₅₀	807 nM Compound: GSK3203591	Antiproliferative activity against human SK-MES-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-MES-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-N-AS	GI₅₀	31.9 nM Compound: GSK3203591	Antiproliferative activity against human SK-N-AS cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-N-AS cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-N-DZ	GI₅₀	257 nM Compound: GSK3203591	Antiproliferative activity against human SK-N-DZ cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-N-DZ cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-N-FI	GI₅₀	308 nM Compound: GSK3203591	Antiproliferative activity against human SK-N-FI cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-N-FI cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-NEP-1	GI₅₀	264 nM Compound: GSK3203591	Antiproliferative activity against human SK-NEP-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-NEP-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-OV-3	GI₅₀	52.6 nM Compound: GSK3203591	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SK-UT-1	GI₅₀	42.1 nM Compound: GSK3203591	Antiproliferative activity against human SK-UT-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SK-UT-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SNB-19	GI₅₀	223 nM Compound: GSK3203591	Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SNU-16	GI₅₀	34.4 nM Compound: GSK3203591	Antiproliferative activity against human SNU-16 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SNU-16 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SNU-423	GI₅₀	66 nM Compound: GSK3203591	Antiproliferative activity against human SNU-423 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SNU-423 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SNU-5	GI₅₀	110 nM Compound: GSK3203591	Antiproliferative activity against human SNU-5 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SNU-5 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SNU1	GI₅₀	1040 nM Compound: GSK3203591	Antiproliferative activity against human SNU1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SNU1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SR	GI₅₀	275 nM Compound: GSK3203591	Antiproliferative activity against human SR cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SR cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
ST486	GI₅₀	101 nM Compound: GSK3203591	Antiproliferative activity against human ST486 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human ST486 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SU-DHL-16	GI₅₀	0.124 μM Compound: GSK3203591	Antiproliferative activity against human SU-DHL-16 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SU-DHL-16 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SU-DHL-2	GI₅₀	0.086 μM Compound: GSK3203591	Antiproliferative activity against human SUDHL2 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SUDHL2 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SU-DHL-5	GI₅₀	0.132 μM Compound: GSK3203591	Antiproliferative activity against human SU-DHL-5 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SU-DHL-5 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SU-DHL-6	GI₅₀	0.013 μM Compound: GSK3203591	Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SU-DHL-8	GI₅₀	1.22 μM Compound: GSK3203591	Antiproliferative activity against human SU-DHL-8 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SU-DHL-8 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SU-DHL10	GI₅₀	0.495 μM Compound: GSK3203591	Antiproliferative activity against human SU-DHL-10 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SU-DHL-10 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SU.86.86	GI₅₀	934 nM Compound: GSK3203591	Antiproliferative activity against human SU-86-86 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SU-86-86 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SUD4	GI₅₀	0.571 μM Compound: GSK3203591	Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SW 954	GI₅₀	10000 nM Compound: GSK3203591	Antiproliferative activity against human SW 954 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW 954 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW 962	GI₅₀	203 nM Compound: GSK3203591	Antiproliferative activity against human SW 962 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW 962 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW-620	GI₅₀	5640 nM Compound: GSK3203591	Antiproliferative activity against human SW620 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW620 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW1088	GI₅₀	40.5 nM Compound: GSK3203591	Antiproliferative activity against human SW1088 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW1088 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW13	GI₅₀	211 nM Compound: GSK3203591	Antiproliferative activity against human SW13 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW13 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW1353	GI₅₀	129 nM Compound: GSK3203591	Antiproliferative activity against human SW1353 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW1353 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW1417	GI₅₀	773 nM Compound: GSK3203591	Antiproliferative activity against human SW1417 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW1417 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW1463	GI₅₀	770 nM Compound: GSK3203591	Antiproliferative activity against human SW1463 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW1463 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW1783	GI₅₀	389 nM Compound: GSK3203591	Antiproliferative activity against human SW1783 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW1783 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW48	GI₅₀	10000 nM Compound: GSK3203591	Antiproliferative activity against human SW48 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW48 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW480	GI₅₀	413 nM Compound: GSK3203591	Antiproliferative activity against human SW480 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW480 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW684	GI₅₀	1170 nM Compound: GSK3203591	Antiproliferative activity against human SW684 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW684 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW780	GI₅₀	0.451 μM Compound: GSK3203591	Antiproliferative activity against human SW780 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human SW780 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
SW837	GI₅₀	102 nM Compound: GSK3203591	Antiproliferative activity against human SW837 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW837 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW872	GI₅₀	54 nM Compound: GSK3203591	Antiproliferative activity against human SW872 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW872 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW900	GI₅₀	3250 nM Compound: GSK3203591	Antiproliferative activity against human SW900 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW900 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW948	GI₅₀	120 nM Compound: GSK3203591	Antiproliferative activity against human SW948 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW948 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SW982	GI₅₀	56.7 nM Compound: GSK3203591	Antiproliferative activity against human SW982 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SW982 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
SiHa	GI₅₀	2510 nM Compound: GSK3203591	Antiproliferative activity against human SiHa cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human SiHa cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
T-24	GI₅₀	0.65 μM Compound: GSK3203591	Antiproliferative activity against human T24 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human T24 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
T-24	GI₅₀	449 nM Compound: GSK3203591	Antiproliferative activity against human T24 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human T24 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
T47D	GI₅₀	52.4 nM Compound: GSK3203591	Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human T47D cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
T98G	GI₅₀	27.3 nM Compound: GSK3203591	Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
TCC-SUP	GI₅₀	235 nM Compound: GSK3203591	Antiproliferative activity against human TCC-SUP cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human TCC-SUP cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
THP-1	GI₅₀	80.5 nM Compound: GSK3203591	Antiproliferative activity against human THP-1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human THP-1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
U-251	GI₅₀	3.491 μM Compound: GSK3203591	Antiproliferative activity against human U-251MG cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human U-251MG cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
U-266	GI₅₀	78.5 nM Compound: GSK3203591	Antiproliferative activity against human U266B1 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human U266B1 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
U-2940	GI₅₀	2.349 μM Compound: GSK3203591	Antiproliferative activity against human U-2940 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human U-2940 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
U-87MG ATCC	GI₅₀	0.127 μM Compound: GSK3203591	Antiproliferative activity against human U-87 MG cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human U-87 MG cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
U-87MG ATCC	GI₅₀	67.6 nM Compound: GSK3203591	Antiproliferative activity against human U-87 MG cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human U-87 MG cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
U-937	GI₅₀	0.049 μM Compound: GSK3203591	Antiproliferative activity against human U-937 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human U-937 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
U138-MG	GI₅₀	43.3 nM Compound: GSK3203591	Antiproliferative activity against human U138-MG cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human U138-MG cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
U2932	GI₅₀	0.336 μM Compound: GSK3203591	Antiproliferative activity against human U2932 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human U2932 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
U2OS	GI₅₀	485 nM Compound: GSK3203591	Antiproliferative activity against human U2OS cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human U2OS cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
UMUC3	GI₅₀	105 nM Compound: GSK3203591	Antiproliferative activity against human UMUC3 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human UMUC3 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
UMUC3	GI₅₀	19.169 μM Compound: GSK3203591	Antiproliferative activity against human UMUC3 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human UMUC3 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
WI-38	GI₅₀	18.5 nM Compound: GSK3203591	Antiproliferative activity against human WI-38 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human WI-38 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
WSU-NHL	GI₅₀	0.076 μM Compound: GSK3203591	Antiproliferative activity against human WSU-NHL cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human WSU-NHL cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
WSUDLCL2	GI₅₀	0.651 μM Compound: GSK3203591	Antiproliferative activity against human WSUDLCL2 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human WSUDLCL2 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
WiDr	GI₅₀	505 nM Compound: GSK3203591	Antiproliferative activity against human WiDr cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human WiDr cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Y79	GI₅₀	113 nM Compound: GSK3203591	Antiproliferative activity against human Y79 cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human Y79 cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
YAPC	GI₅₀	168 nM Compound: GSK3203591	Antiproliferative activity against human YAPC cells assessed as cell growth inhibition incubated for 10 days Antiproliferative activity against human YAPC cells assessed as cell growth inhibition incubated for 10 days	[PMID: 29946150]
Z-138	GI₅₀	0.014 μM Compound: GSK3203591	Antiproliferative activity against human Z138 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human Z138 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]
Z-138	IC₅₀	62 nM Compound: EPZ015866; GSK3203591	Antiproliferative activity against human Z138 cells incubated for 5 days by cell titer-glo assay Antiproliferative activity against human Z138 cells incubated for 5 days by cell titer-glo assay	[PMID: 26985292]
ZR-75-1	GI₅₀	2.615 μM Compound: GSK3203591	Antiproliferative activity against human ZR-75-1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay Antiproliferative activity against human ZR-75-1 cells assessed as cell growth inhibition incubated for 6 days by celltiter-glo assay	[PMID: 29946150]

In Vitro

GSK591 (5 μM; MCF7, T47D, and MCF10A cells) treatment suppresses breast cancer stem cells (BCSCs) proliferation and self-renewal. GSK591 reduces BCSCs numbers in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:	MCF7, T47D, and MCF10A cells
Concentration:	5 μM
Incubation Time:
Result:	Suppressed BCSCs proliferation and self-renewal.

Molecular Weight

380.48

Formula

C₂₂H₂₈N₄O₂

CAS No.

1616391-87-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(NC2CCC2)=NC=C1)NC[C@H](O)CN3CC4=C(C=CC=C4)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (131.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6283 mL	13.1413 mL	26.2826 mL
5 mM	0.5257 mL	2.6283 mL	5.2565 mL
10 mM	0.2628 mL	1.3141 mL	2.6283 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.25 mg/mL (5.91 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.25 mg/mL (5.91 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.25 mg/mL (5.91 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (245 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. [1] Kenneth W. Duncan et al. Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med. Chem. Lett., 2016, 7 (2), pp 162-166. [Content Brief]

[2]. Chiang K, et al. PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression. Cell Rep. 2017 Dec 19;21(12):3498-3513. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6283 mL	13.1413 mL	26.2826 mL	65.7065 mL
	5 mM	0.5257 mL	2.6283 mL	5.2565 mL	13.1413 mL
	10 mM	0.2628 mL	1.3141 mL	2.6283 mL	6.5706 mL
	15 mM	0.1752 mL	0.8761 mL	1.7522 mL	4.3804 mL
	20 mM	0.1314 mL	0.6571 mL	1.3141 mL	3.2853 mL
	25 mM	0.1051 mL	0.5257 mL	1.0513 mL	2.6283 mL
	30 mM	0.0876 mL	0.4380 mL	0.8761 mL	2.1902 mL
	40 mM	0.0657 mL	0.3285 mL	0.6571 mL	1.6427 mL
	50 mM	0.0526 mL	0.2628 mL	0.5257 mL	1.3141 mL
	60 mM	0.0438 mL	0.2190 mL	0.4380 mL	1.0951 mL
	80 mM	0.0329 mL	0.1643 mL	0.3285 mL	0.8213 mL
	100 mM	0.0263 mL	0.1314 mL	0.2628 mL	0.6571 mL

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GSK5911616391-87-7EPZ015866 GSK3203591GSK 591GSK-591EPZ 015866EPZ-015866GSK3203591GSK 3203591GSK-3203591Histone MethyltransferaseInhibitorinhibitorinhibit

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GSK591 (Synonyms: EPZ015866; GSK3203591)

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