GSK591 hydrochloride (Synonyms: EPZ015866 hydrochloride; GSK3203591 hydrochloride)

Cat. No.: HY-100235A: FAQs
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GSK591 (EPZ015866) hydrochloride is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC₅₀ of 4 nM.

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GSK591 hydrochloride Chemical Structure

CAS No. : 2320953-89-5

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GSK591

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: GSK591 hydrochloride purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2022 Nov 16;422(1):113413. [Abstract]; GSK591 (PRMT5i; 200-1000 nM) in combination with EPZ020411 (PRMT6i; 200-1000 nM) exhibits a synergistic anti-proliferative effect on HCT116 and SW620 cells.

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Description	GSK591 (EPZ015866) hydrochloride is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC₅₀ of 4 nM^[1].
IC₅₀ & Target	IC50: 4 nM (PRMT5)^[1]
Molecular Weight	453.41
Formula	C₂₂H₃₀Cl₂N₄O₂
CAS No.	2320953-89-5
SMILES	O=C(C1=CC(NC2CCC2)=NC=C1)NC[C@H](O)CN3CC4=C(C=CC=C4)CC3.Cl.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (241 KB) Handling Instructions (2659 KB)

GSK591 hydrochloride Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK5912320953-89-5EPZ015866GSK3203591GSK 591GSK-591EPZ 015866EPZ-015866GSK 3203591GSK-3203591Histone MethyltransferaseInhibitorinhibitorinhibit

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GSK591 hydrochloride (Synonyms: EPZ015866 hydrochloride; GSK3203591 hydrochloride)

Other Forms of GSK591 hydrochloride:

GSK591 hydrochloride Related Antibodies

11 Publications Citing Use of MCE GSK591 hydrochloride