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SRGAP2 - SLIT-ROBO Rho GTPase activating protein 2 Gene

Also Known as FNBP2; SRGAP3; SRGAP2A; ARHGAP34

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23380

About SRGAP2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,203,541-206,464,436 (from NCBI)

This gene has 16 transcripts (splice variants), 221 orthologues and 5 paralogues. Ubiquitous expression in skin (RPKM 12.4), spleen (RPKM 10.1) and 23 other tissues.

Summary

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]

SRGAP2 Products (7)

mRNA	Protein	Name
NM_001170637.4	NP_001164108.1	SLIT-ROBO Rho GTPase-activating protein 2 isoform c
NM_001300952.2	NP_001287881.1	SLIT-ROBO Rho GTPase-activating protein 2 isoform d
NM_001377444.1	NP_001364373.1	SLIT-ROBO Rho GTPase-activating protein 2 isoform e
NM_001377445.1	NP_001364374.1	SLIT-ROBO Rho GTPase-activating protein 2 isoform f
NM_001377446.1	NP_001364375.1	SLIT-ROBO Rho GTPase-activating protein 2 isoform g
NM_001377447.1	NP_001364376.1	SLIT-ROBO Rho GTPase-activating protein 2 isoform h
NM_015326.5	NP_056141.2	SLIT-ROBO Rho GTPase-activating protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	21148482	GOA
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	20810653	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20810653	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	20810653	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	20810653	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament severing	IDA IDA: Inferred from direct assay	21148482	GOA
involved in dendritic spine development	IDA IDA: Inferred from direct assay	22559944	GOA
involved in excitatory synapse assembly	IDA IDA: Inferred from direct assay	27373832	GOA
involved in filopodium assembly	IDA IDA: Inferred from direct assay	22559944	GOA
involved in inhibitory synapse assembly	IDA IDA: Inferred from direct assay	27373832	GOA
involved in lamellipodium assembly involved in ameboidal cell migration	IMP IMP: Inferred from mutant phenotype	20810653	GOA
involved in negative regulation of neuron migration	IDA IDA: Inferred from direct assay	22559944	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	21148482	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	20810653	GOA
involved in substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	20810653	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in dendritic spine head	IDA IDA: Inferred from direct assay	22559944	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	20810653	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21148482	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SLIT-ROBO Rho GTPase-activating protein 2	SLIT-ROBO GAP2

SRGAP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRGAP2	O75044	SRGAP2	Homo sapiens	O75044	Anti Tag CoIP	20810653
Intra	SRGAP2	O75044	SRGAP2	Homo sapiens	O75044	X-Ray Diffraction	26365803
Intra	SRGAP2	O75044	SRGAP2	Homo sapiens	O75044	Crosslink	26365803
Intra	SRGAP2	O75044	YWHAG	Homo sapiens	P61981	CoIP	15324660
Intra	SRGAP2	O75044	SRGAP2	Homo sapiens	O75044	SLS	26365803
Intra	SRGAP2	O75044	SRGAP2	Homo sapiens	O75044	GMS	26365803
Intra	SRGAP2	O75044	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	SRGAP2	O75044	PRMT5	Homo sapiens	O14744	Methyltransferase Ass	20810653
Intra	SRGAP2	O75044	PRMT5	Homo sapiens	O14744	Anti Bait CoIP	20810653
Intra	SRGAP2	O75044	ROBO1	Homo sapiens	Q9Y6N7	SPR	26365803
Intra	SRGAP2	O75044	ROBO1	Homo sapiens	Q9Y6N7	MST	26365803
Intra	SRGAP2	O75044	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	SRGAP2	O75044	FASLG	Homo sapiens	P48023	Phage Display	19807924
Intra	SRGAP2	O75044	FASLG	Homo sapiens	P48023	Pull Down	16318909
Intra	SRGAP2	O75044	FMNL1	Homo sapiens	O95466	Anti Bait CoIP	21148482
Intra	SRGAP2	O75044	FMNL1	Homo sapiens	O95466	Pull Down	21148482
Cross	SRGAP2	O75044	Fmnl3	Mus musculus	Q6ZPF4	Y2H	21148482

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Non-Specific Early-Onset Epileptic Encephalopathy	Undetermined Early-Onset Epileptic Encephalopathy Non-Specific Eoee Undetermined Eoee
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile
Chromosome 3pter-P25 Deletion Syndrome	3p- Syndrome 3p Deletion Syndrome Distal Monosomy 3p Chromosome 3, Monosomy 3p 3p Partial Monosomy Syndrome Chromosome 3, Deletion 3p Chromosome 3p Deletion Syndrome Del Syndrome Deletion 3p Monosomy 3p Partial Monosomy 3p Distal 3p Deletion Monosomy 3pter Telomeric Monosomy 3p Chromosome Deletion Syndrome 3pter-P25
Lissencephaly 5	LIS5 Cobblestone Lissencephaly Without Muscular Or Ocular Involvement Cobblestone Lissencephaly Without Muscular Or Eye Involvement Lissencephaly Type 2 Without Muscular Or Eye Involvement Lissencephaly Type 2 Without Muscular Or Ocular Involvement Lissencephaly, Type 5
Avoidant Personality Disorder	Anxious Personality Disorder Personality Disorders
Pilomyxoid Astrocytoma
Retinitis Pigmentosa 23	RP23 Retinitis Pigmentosa-23 Retinitis Pigmentosa, Type 23 Rp23 Gene
Fibrillary Astrocytoma	Fibrillary Astrocytic Tumors Diffuse Astrocytoma Gemistocytic Astrocytoma Protoplasmic Astrocytoma
Childhood Pilocytic Astrocytoma	Pediatric Pilocytic Astrocytoma
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13763	SRGAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13764	SRGAP2C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13765	SRGAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SRGAP2	VGNC	VGNC:107944
Macaca mulatta	SRGAP2	VGNC	VGNC:99699
Rattus norvegicus	SRGAP2	RGD	RGD:1566016
Bos taurus	SRGAP2	VGNC	VGNC:108505
Mus musculus	SRGAP2	MGD	MGI:109605
Others	SRGAP2	NCBI