FMNL1 - formin like 1 Gene

Also Known as FMNL; FHOD4; KW-13; C17orf1; C17orf1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 752

About FMNL1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,221,885-45,247,318 (from NCBI)

This gene has 11 transcripts (splice variants), 287 orthologues and 18 paralogues. Biased expression in bone marrow (RPKM 59.8), appendix (RPKM 26.8) and 11 other tissues.

Summary

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

FMNL1 Products (2)

mRNA	Protein	Name
NM_001411128.1	NP_001398057.1	formin-like protein 1 isoform 2
NM_005892.4	NP_005883.3	formin-like protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activating protein binding	IDA IDA: Inferred from direct assay	21148482	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21148482	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cortical actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	21834987	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FMNL1 Protein Structure

Drf_GBD

Drf_FH3

FH2

0
200
400
600
800
1000
1100 a.a.

Protein Preferred Names	Protein Names
formin-like protein 1	CLL-associated antigen KW-13

FMNL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FMNL1	O95466	SRGAP2	Homo sapiens	O75044	Anti Tag CoIP	21148482

Cross: Cross-species interaction Intra: Intraspecies interaction

FMNL1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89580	FMNL1 Antibody (YA8924)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Malignant Breast Melanoma	Malignant Melanoma Of Breast Breast Melanoma
Cerebral Amyloid Angiopathy, Itm2b-Related, 2	Dementia, Familial Danish Fdd Familial Danish Dementia Heredopathia Ophthalmootoencephalica Hooe Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis Adan Amyloidosis Itm2b-Related Cerebral Amyloid Angiopathy 2 Itm2b Amyloidosis Familial Cerebral Amyloid Angiopathy Itm2b-Related Amyloidosis Itm2b-Related Cerebral Amyloid Angiopathy Familial Dementia, Danish Type Cerebral Amyloid Angiopathy, Itm2b-Related 2 CAA-ITM2B2 Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis Dementia, Familial, Danish
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05002	FMNL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22510	Fmnl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29031	Fmnl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FMNL1	VGNC	VGNC:40914
Felis catus	FMNL1	VGNC	VGNC:62304
Macaca mulatta	FMNL1	VGNC	VGNC:72480
Rattus norvegicus	FMNL1	RGD	RGD:1311042
Mus musculus	FMNL1	MGD	MGI:1888994
Bos taurus	FMNL1	VGNC	VGNC:29046
Others	FMNL1	NCBI