2. Epigenetics
  3. Histone Methyltransferase
  4. PRMT5-IN-30

PRMT5-IN-30 (compound 17) is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.33 μM and a Kd of 0.987 μM. PRMT5-IN-30 exhibits a broad selectivity against a panel of other methyltransferases. PRMT5-IN-30 inhibits PRMT5 mediated SmD3 methylation.

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PRMT5-IN-30 Chemical Structure

PRMT5-IN-30 Chemical Structure

CAS No. : 330951-01-4

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PRMT5-IN-30 Related Antibodies

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Description

PRMT5-IN-30 (compound 17) is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.33 μM and a Kd of 0.987 μM. PRMT5-IN-30 exhibits a broad selectivity against a panel of other methyltransferases. PRMT5-IN-30 inhibits PRMT5 mediated SmD3 methylation[1].

IC50 & Target[1]

PRMT5

0.33 μM (IC50)

PRMT5

0.987 μM (Kd)

Molecular Weight

371.41

Formula

C18H17N3O4S
CAS No.
Appearance

Powder

Color

White to off-white

SMILES

C1(SCC(=O)NC2C=CC=CC=2C(OC)=O)NC2C(=CC=C(OC)C=2)N=1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥95%

COA (249 KB) HNMR (93 KB) LCMS (75 KB)

Handling Instructions (2659 KB)
References
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PRMT5-IN-30 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT5-IN-30330951-01-4Histone MethyltransferasePRMT5 inhibitorSmD3 methylationantitumor activityInhibitorinhibitorinhibit

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